Development of initial material for pea breeding using the methods of hybridization and physical mutagenesis by F. A. Davletov, K. P. Gainullina, I. K. Karimov

“…In this case, the key role belongs to the initial material. Hybridization and mutagenesis methods are widely used to develop initial material. …”
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Comparative study of the biological properties of influenza А virus mutants obtained by site-specific mutagenesis and the live influenza reassortant vaccine variant by Bogdan S. Cherepovich, Artem A. Rtishchev, Irina I. Akopova, Olga V. Borisova, Vladimir Y. Kost, Nina M. Kutuzova, Stanislav G. Markushin

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Favipiravir: the hidden threat of mutagenic action by O. P. Zhirnov, A. I. Chernyshova

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Study of the biological properties of attenuated variants of the virulent A/WSN/33 strain of influenza virus, obtained by the site-specific mutagenesis of PB2-gene by V. Yu. Kost, A. A. Rtischev, R. R. Mintaev, I. I. Akopova, K. V. Lisovskaya, S. G. Markushin

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Imbalanced immunobiological reactivity, infection and mutagenesis factors in the hepatobiliary system affected by a natural focal habitat factor — a trematode invasion by <i>Opisthorchis felineus</i> by A. G. Rybka

“…An interaction between decreasing host anti-infective defense due to long-term invasion with Opisthorchis felineus in the hepatobiliary system, duct bile colonization by microflora and revealing the endogenous mutagenesis (carcinogenesis) factor in bile — secondary bile acids — is considered in the article. …”
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Construction of Candidate <i>Yersinia pestis</i> Vaccine Strains with Reduced Reactogenicity by S. A. Ageev, R. Z. Shaikhutdinova, I. V. Bakhteeva, G. M. Titareva, T. I. Kombarova, S. V. Dentovskaya, A. P. Anisimov

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Results of awnless brome-grass (<i>Bromopsis inermis</i> Leyss.) breeding in Northern Trans-Ural Region by T. P. Lipovtsyna

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Inclusion of site-specific mutations in the PB1-gene of a virulent A/WSN/33 (H1N1) strain of influenza A virus changes its phenotypic characteristics by V. Yu. Kost, O. A. Sukhova, I. I. Akopova, E. O. Gorbacheva, K. V. Lisovskaya, A. A. Rtishchev, S. G. Markushin

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Gene Therapy Medicinal Products: Non-clinical Safety Studies by O. V. Astapova, A. A. Berchatova

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Use of Oxidative Stress (MDA) Markers and Cytogenetic Markers in the Ecological‐Genetic Monitoring of the Northern Caspian Sea by T. V. Kuzina, A. V. Kuzin

“…Our analysis thus leads us to the conclusion that somatic mutagenesis (micronuclear formation) after exposure to free radicals can be an adaptive response to this stress factor.Conclusion. …”
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Hepatitis B virus and site-specific nucleases: effects of genetic modifications in CRISPR/Cas9 on antiviral activity by A. P. Kostyusheva, S. A. Brezgin, D. N. Zarifyan, D. S. Chistyakov, V. I. Gegechkory, E O. Bayurova, E. A. Volchkova, D. S. Kostyushev, V. P. Chulanov

“…Second, CRISPR/Cas9-mediated off-target mutagenesis represents a menacing problem which has to be addressed. …”
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The role of retroelements in the development of hereditary tumor syndromes by R. N. Mustafin, E. K. Khusnutdinova

“…Oncosuppressor genes contain hot spots of insertional mutagenesis, therefore retroelements cause their inactivation. …”
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Truncation of Lipopolysaccharide Core Decreases <i>Yersinia pestis</i> Virulence by S. V. Dentovskaya, M. E. Platonov, T. I. Kombarova, G. M. Titareva, I. V. Bakhteeva, R. Z. Shaikhutdinova, S. A. Ivanov, A. P. Anisimov

“…The isogenic set of Yersinia pestis strains including wild-type strain 231 and its mutants with deletions of the structural genes, wabD, waaL, waaQ, waaE, and hldE, responsible for core oligosaccharide synthesis was generated using site directed mutagenesis. It was shown that gradual decrease of the core-oligosaccharide length was accompanied by reduction of mutants' virulence in subcutaneously infected mice and guinea pigs.…”
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Increasing of barley productivity and adaptability by using genetic modification technologies by A. V. Bakulina, I. G. Shirokikh

“…The latest technologies of targeted mutagenesis used for genome editing (ZFN, TALEN and CRISPR/Cas9 systems) are observed. …”
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Identification of Surface Glycoprotein Mutations of SARS-CoV-2 in Isolated Strains from Iraq by Ali A. Dawood, B. I. Jasim, O. Riadh Al-Jalily

“…Using statistical saturation mutagenesis and other informatics methods, we investigated 20 sequences of SARS-CoV-2 S protein missense mutation isolates in Iraq selected from NCBI.The following mutations were detected for all the strains under study compared to the wild type: L452R, A522V, E583D and D614G. …”
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SOFTWARE REQUIREMENTS FOR THE PERSPECTIVE FILBERT GENEPOOL (HAZELNUT) by S. G. Biganova, Yu. I. Sukhorukikh, E. K. Pchikhachev

“…Plant bushes should have moderate growth of up to 3 m in height and diameter of the crown, uniform ripening of fruits within 85-90 %, a husk less than a nut, entry into marketable fruiting since 4-5 years of age.The target yield of the kernel is more than 810 kg/ha, the fruits of the selection category are of high quality (at least 45 points), the fat content is 60-70 %, protein is 12-18 %, and the shelf life is up to 2 years.The creation of new varieties is carried out on the basis of hybridization, clonal selection, mutagenesis, genetic engineering methods, pedigree and polyploidy. …”
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THE ROLE OF mutR GENE IN METABOLISM AND VIRULENCE OF emm12 GENOTYPE STREPTOCOCCUS PYOGENES STRAINS by A. A. Zutkis, B. L. Milman, A. V. Dmitriev

“…The mutR gene was inactivated in the strains no. 97 and no. 152 by insertional mutagenesis. Inactivation of the mutR gene was found to affect the dynamic and characteristics of bacterial growth in liquid medium. …”
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Virulence for Mice of pH6⁺ and pH6^– <i>Yersinia pestis</i> Strains by I. V. Bakhteyeva, S. V. Dentovskaya, E. A. Panfertsev, T. E. Svetoch, T. B. Kravchenko, M. E. Platonov, G. M. Titareva, T. I. Kombarova, S. A. Ivanov, A. P. Anissimov

“…The technique of site-directed mutagenesis of psa operon encoding the synthesis of pH6 antigen (adhesion pili), followed by the trans-complementation procedure were used to construct two sets of isogenic Yersinia pestis strains including wild type strains 231 and I-1996, their non-polar pH6- mutants containing deletions in the structural psA gene or in the entire operon, as well as the strains which could recover their capability for temperature- and pH-dependent synthesis of the adhesion pili or the constitutive pH6 antigen production. …”
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Construction and Investigation of the Vaccine Strain Francisella tularensis without iglC genes. Communication 1 by A. N. Mokrievich, G. M. Vakhrameeva, R. I. Mironova, T. I. Kombarova, G. M. Titareva, T. B. Kravchenko, I. V. Bakhteeva, I. A. Dyatlov, V. M. Pavlov

“…Using site-specific mutagenesis constructed were the variants of the vaccine strain F. tularensis subsp. holarctica 15 with the deleted iglC genes. …”
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COXIELLA BURNETII PATHOGENICITY MOLECULAR BASIS by Yu. A. Panferova

“…Identification and characterization of novel virulence factors it is now possible through axenic media for C. burnetii cultivation and development of site-specific mutagenesis and other genetic technics, which is important for research of C. burnetii molecular pathogenesis.…”
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