Effects of pertussis toxin and <i>Bordetella pertussis</i> lipo-oligosaccharide on the specific toxicity and potency of whole-cell pertussis vaccines by I. A. Alekseeva, I. V. Ibragimkhalilova, D. N. Lepekhova

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Protective Activity and Safety of Acellular Pertussis Vaccine from Vaccine and Freshly Isolated Strain Bordetella pertussis by E. M. Zaitsev, I. G. Bazhanova, M. V. Britsina

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MODERNIZATION OF GENEOTIPING OF STRAINS B. PERTUSSIS by G. A. Ivashinnikova, O. U. Borisova, A. V. Aleshkin, A. S. Pimenova, V. A. Aleshkin

“…The new rapid molecular genotyping method was developed for studying the structure of ptxP promoter of pertussis toxin. Method is based on PCR-RFLP analysis, which allows studying the specific restriction profiles of the B. pertussis strains and allows differentiation of the strains with the ptxP structural particularities. …”
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Clinico-Epidemiological And Microbiological Evolution Of Pertussis by I. V. Babachenko

“…Strains of B. рertussis of serotypes 1.0.3., IVb EFPP-group (during electrophoresis in pulsating gel), pertussis toxin A, pertactin 2 are associated with less severe illness forms (by 2,5 times), as well as specific complications (breath-holding and pertussis encephalopathy).…”
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FEATURES OF GENOTYPiNG VARIABILITY OF STRAINS OF BORDETELLA PERTUSSIS ALLOCATED FROM PATIENTS WITH WHOOPING COUGH IN RUSSIA by V. A. Aleshkin, O. Yu. Borisova, N. T. Gadua, I. K. Mazurova

“…Dynamics of formation of population of strains of the causative agent of whooping cough is tracked and is established that population of strains of B.pertussis is formed by clonal expansion of strains with, new genetic structure of major factors of pathogenicity - pertussis toxin and. pertactin. The structure of population of strains of B.pertussis causing a disease by whooping cough, at the present stage of epidemic process of a pertussis infection - domination. of strains with new «non-vaccine» alleles genes - ptxA1 (97,7 %), ptxC2 (87,4 %), prn2 (89,5 %) and. ptxP3 (93,3 %), in 2,2 % cases with ptxB2 allele and. in 1,3 % cases with. prn9 allele circulate.…”
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Pertussis immunity in pregnant women and factors associated with seronegative status by E. A. Krieger, O. V. Samodova, L. V. Titova

“…SeroPertussis IgG (Israel) ELISA kit was used to quantitate antibodies against pertussis toxin/hemagglutinin. Binary logistic regression analysis was performed to assess factors associated with seronegative status. …”
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REGULATORY MECHANISMS OF HUMAN MONOCYTIC THP-1 CELLS TRANSENDOTHELIAL MIGRATION INDUCED BY STREPTOCOCCUS PYOGENES COMPONENTS by E. A. Starikova, A. M. Lebedeva, N. A. Aktureeva, L. A. Burova, I. S. Freidlin

“…Preincubation of THP-1 cells with pertussis toxin did reduce the transmigration intensity in presence of the SSC down to the level of spontaneous migration. …”
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Acellular Pertussis Vaccine from Antigens of Freshly Isolated and Vaccine Strains of Bordetella pertussis with Different Genotypic Characteristics by E. M. Zaitsev, I. G. Bazhanova, M. V. Britsina, N. U. Mertsalova, M. N. Ozeretskovskaya

“…Freshly isolated (No. 287, and No. 317) and vaccine (No. 305 and No. 475) B. pertussis strains with «non-vaccine» and «vaccine» allelic variants of the pertussis toxin (PT) subunit A gene, the PT promoter gene, the pertactin gene, the fimbria 2 gene, and the fimbria 3 gene strains were used for the production of AcPV.Results. …”
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Safety and immunogenicity of live intranasal pertussis vaccine GamLVP in the experimental infant hamadryas baboon model by A. A. Djidaryan, A. Z. Matua, A. Yu. Medkova, E. G. Semin, L. N. Sinyashina, I. N. Dyakov, I. N. Chernyshova, D. T. Kubrava, A. A. Amichba, I. G. Kondzariya, Z. Ya. Mikvabiya, G. I. Karataev

“…The intranasal immunization of P. hamadryas infants with the GamLVP vaccine triggered development of a specific humoral immune response mediated by IgG antibodies (pertussis toxin + filamentous hemagglutinin), increased titers of total agglutinating anti-pertussis antibodies, caused no local and systemic reactions, caused no changes in the complete blood count and biochemical profile. …”
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