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Multiscale Modeling of Red Blood Cell Mechanics and Blood Flow in Malaria
Published 2012“…Red blood cells (RBCs) infected by a Plasmodium parasite in malaria may lose their membrane deformability with a relative membrane stiffening more than ten-fold in comparison with healthy RBCs leading to potential capillary occlusions. …”
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Blood, Guts, and Hope
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Estimation of changes in instantaneous aortic blood flow by the analysis of arterial blood pressure
Published 2013“…The purpose of this study was to introduce and validate a new algorithm to estimate instantaneous aortic blood flow (ABF) by mathematical analysis of arterial blood pressure (ABP) waveforms. …”
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Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence
Published 2015“…Methods We analyzed data from whole-exome sequencing of DNA in peripheral-blood cells from 12,380 persons, unselected for cancer or hematologic phenotypes. …”
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Blood Banking in Living Droplets
Published 2011“…Blood banking has a broad public health impact influencing millions of lives daily. …”
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Microfluidic Devices for Blood Fractionation
Published 2014“…Blood, a complex biological fluid, comprises 45% cellular components suspended in protein rich plasma. …”
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Artificial arterial blood pressure artifact models and an evaluation of a robust blood pressure and heart rate estimator
Published 2010“…Background: Within the intensive care unit (ICU), arterial blood pressure (ABP) is typically recorded at different (and sometimes uneven) sampling frequencies, and from different sensors, and is often corrupted by different artifacts and noise which are often non-Gaussian, nonlinear and nonstationary. …”
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Deformability of Tumor Cells versus Blood Cells
Published 2016“…However, CTCs are rare in the blood, and universal properties with which to identify them remain elusive. …”
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Observation of dynamic subdomains in red blood cells
Published 2014“…We quantify the nanoscale structure and low-frequency dynamics associated with live red blood cells. The membrane displacements are measured using quantitative phase images provided by Fourier phase microscopy, with an average path-length stability of 0.75 nm over 45 min. …”
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An Immune Response Network Associated with Blood Lipid Levels
Published 2011“…Thus, this study generated genome-wide profiles of both genetic and transcriptional variation from the total blood extracts of over 500 randomly-selected, unrelated individuals. …”
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The cardiac output from blood pressure algorithms trial
Published 2011“…Objective: The value of different algorithms that estimate cardiac output (CO) by analysis of a peripheral arterial blood pressure (ABP) waveform has not been definitively identified. …”
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Metabolic remodeling of the human red blood cell membrane
Published 2011“…The remarkable deformability of the human red blood cell (RBC) results from the coupled dynamic response of the phospholipid bilayer and the spectrin molecular network. …”
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Measurement of the nonlinear elasticity of red blood cell membranes
Published 2011“…The membranes of human red blood cells (RBCs) are a composite of a fluid lipid bilayer and a triangular network of semiflexible filaments (spectrin). …”
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Quantitative cerebral blood flow with optical coherence tomography
Published 2012“…Absolute measurements of cerebral blood flow (CBF) are an important endpoint in studies of cerebral pathophysiology. …”
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Sampling Blood from the Lateral Tail Vein of the Rat
Published 2015“…Blood samples are commonly obtained in many experimental contexts to measure targets of interest, including hormones, immune factors, growth factors, proteins, and glucose, yet the composition of the blood is dynamically regulated and easily perturbed. …”
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Anisotropic light scattering of individual sickle red blood cells
Published 2012“…We present the anisotropic light scattering of individual red blood cells (RBCs) from a patient with sickle cell disease (SCD). …”
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Painting blood vessels and atherosclerotic plaques with an adhesive drug depot
Published 2013“…Implanting materials using adhesive forces could overcome this challenge, but materials have previously not been shown to durably adhere to intact endothelium under blood flow. Marine mussels secrete strong underwater adhesives that have been mimicked in synthetic systems. …”
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Lipid bilayer and cytoskeletal interactions in a red blood cell
Published 2014“…We study the biomechanical interactions between the lipid bilayer and the cytoskeleton in a red blood cell (RBC) by developing a general framework for mesoscopic simulations. …”
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