‘Model’ or ‘tool’? New definitions for translational research by Sive, Hazel

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Detection and characterization of translational research in cancer and cardiovascular medicine by Jones, David Shumway, Cambrosio, Alberto, Andrei, Mogoutov

“…Background Scientists and experts in science policy have become increasingly interested in strengthening translational research. Efforts to understand the nature of translational research and monitor policy interventions face an obstacle: how can translational research be defined in order to facilitate analysis of it? …”
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Squishy Non-Spherical Hydrogel Microparticles by Haghgooie, Ramin, Toner, Mehmet, Doyle, Patrick S.

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Pancreas-enriched miRNAs are altered in the circulation of subjects with diabetes: a pilot cross-sectional study by Nunez Lopez, Yury O., Xie, Hui, Yi, Fanchao, Mathews, Clayton, Pasarica, Magdalena, Pratley, Richard E., Seyhan, Attila A

“…The study was conducted at the Translational Research Institute for Metabolism and Diabetes (TRI-MD), Florida Hospital. …”
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The Lin28/let-7 Axis Regulates Glucose Metabolism by Zhu, Hao, Shyh-Chang, Ng, Segrè, Ayellet V., Shinoda, Gen, Shah, Samar P., Einhorn, William S., Takeuchi, Ayumu, Engreitz, Jesse Michael, Hagan, John P., Kharas, Michael G., Urbach, Achia, Thornton, James E., Triboulet, Robinson, Gregory, Richard I., Altshuler, David, Daley, George Q.

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Genes, circuits, and precision therapies for autism and related neurodevelopmental disorders by Sahin, Mustafa, Sur, Mriganka

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Human Pancreatic Cancer Tumors Are Nutrient Poor and Tumor Cells Actively Scavenge Extracellular Protein by Kamphorst, J. J., Nofal, M., Commisso, C., Hackett, S. R., Lu, W., Grabocka, E., Miller, G., Drebin, J. A., Bar-Sagi, D., Thompson, C. B., Rabinowitz, J. D., Vander Heiden, Matthew G.

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Expression of Multiple Artificial MicroRNAs from a Chicken miRNA126-Based Lentiviral Vector by Chen, Steve C.-Y., Stern, Patrick, Guo, Zhuyan, Chen, Jianzhu

“…Background: The use of RNAi in both basic and translational research often requires expression of multiple siRNAs from the same vector. …”
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Compression of Structured High-Throughput Sequencing Data by Campagne, Fabien, Dorff, Kevin C., Chambwe, Nyasha, Robinson, James T., Mesirov, Jill P.

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Photodynamic Therapy for Cancer and Activation of Immune Response by Mroz, Pawel, Huang, Ying-Ying, Hamblin, Michael R.

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Interactive Whole-Heart Segmentation in Congenital Heart Disease by Pace, Danielle Frances, Dalca, Adrian Vasile, Geva, Tal, Powell, Andrew J., Moghari, Mehdi H., Golland, Polina

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Aberrant Glycosylation Promotes Lung Cancer Metastasis through Adhesion to Galectins in the Metastatic Niche by Reticker-Flynn, Nathan E., Bhatia, Sangeeta N

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Colorectal cancer models for novel drug discovery by Golovko, Daniel, Kedrin, Dmitriy, Yilmaz, Omer, Roper, Jatin

“…Recently developed in vitro and in vivo models overcome some of these deficiencies and thus can be utilized to better model CRC for mechanistic and translational research. Areas Covered; The authors review established models of in vitro cell culture and describe advances in organoid culture for studying normal and malignant intestine. …”
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Disclosing pathogenic genetic variants to research participants: Quantifying an emerging ethical responsibility by Cassa, Christopher A., Savage, Sarah K., Taylor, Patrick L., Green, Robert C., McGuire, Amy L., Mandl, Kenneth D.

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Biphasic Elimination of Tenofovir Diphosphate and Nonlinear Pharmacokinetics of Zidovudine Triphosphate in a Microdosing Study by Chen, Jianmeng, Flexner, Charles, Liberman, Rosa G., Skipper, Paul L., Louissaint, Nicolette A., Hendrix, Craig W., Fuchs, Edward J., Tannenbaum, Steven Robert

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Multilayer thin-film coatings capable of extended programmable drug release: application to human mesenchymal stem cell differentiation by Hong, Jinkee, Alvarez, Luis M., Shah, Nisarg J., Cho, Younghyun, Kim, Byeong-Su, Char, Kookheon, Griffith, Linda G, Hammond, Paula T

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3D microfluidic ex vivo culture of organotypic tumor spheroids to model immune checkpoint blockade by Portell, Andrew, Larios, Dalia, Piel, Brandon P., Mathur, Natasha, Zhou, Chensheng, Coakley, Raven Vlahos, Bartels, Alan, Bowden, Michaela, Herbert, Zach, Gilhooley, Sean, Carter, Jacob, Cañadas, Israel, Thai, Tran C., Kitajima, Shunsuke, Chiono, Valeria, Paweletz, Cloud P., Jenkins, Russell W., Aref, Amir Reza, Ivanova, Elena, Campisi, Marco, Hill, Sarah J, Barbie, David, Kamm, Roger Dale

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Safety, pharmacokinetics, and preliminary assessment of efficacy of mecasermin (recombinant human IGF-1) for the treatment of Rett syndrome by Khwaja, Omar S., Ho, Eugenia, Barnes, Katherine V., O'Leary, Heather M., Pereira, Luis M., Finkelstein, Yaron, Nelson III, Charles A., Vogel-Farley, Vanessa, DeGregorio, Geneva, Holm, Ingrid A., Khatwa, Umakanth, Kapur, Kush, Alexander, Mark E., Finnegan, Deidre M., Cantwell, Nicole G., Walco, Alexandra C., Rappaport, Leonard, Gregas, Matt, Fichorova, Raina N., Shannon, Michael W., Sur, Mriganka, Kaufmann, Walter E.

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Image-based modeling for better understanding and assessment of atherosclerotic plaque progression and vulnerability: Data, modeling, validation, uncertainty and predictions by Tang, Dalin, Yang, Chun, Zheng, Jie, Canton, Gador, Bach, Richard, Huang, Xueying, Hatsukami, Thomas S., Zhu, Jian, Ma, Genshan, Maehara, Akiko, Mintz, Gary S., Yuan, Chun, Kamm, Roger Dale

“…However, a clear understanding is needed about what we have achieved and what is really needed to translate research to actual clinical practices and bring benefits to public health. …”
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