Facial Transplants in Xenopus laevis Embryos by Jacox, Laura A., Dickinson, Amanda J., Sive, Hazel L.

“…Findings in the frog are relevant to human development, since craniofacial processes appear conserved between Xenopus and mammals.…”
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Conservation and divergence of ADAM family proteins in the Xenopus genome by Wei, Shuo, Xu, Guofeng, Bridges, Lance C., Shah, Anoop, White, Judith M., DeSimone, Douglas W., Whittaker, Charles A.

“…We also found evidence for gain of ADAM genes in Xenopus as compared to other species. There is a homologue of ADAM10 in Xenopus that is missing in most mammals. …”
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Induction and patterning of the cement gland during Xenopus laevis embryogenesis by Kennedy, Brenda Schafer

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Identification of a Paralog-Specific Notch1 Intracellular Domain Degron by Broadus, Matthew R., Chen, Tony W., Neitzel, Leif R., Ng, Victoria H., Jodoin, Jeanne, Lee, Laura A., Salic, Adrian, Robbins, David J., Capobianco, Anthony J., Patton, James G., Huppert, Stacey S., Lee, Ethan

“…Upon Notch pathway activation, the receptor is cleaved to release the Notch intracellular domain (NICD), which translocates to the nucleus to activate gene transcription. Using Xenopus egg extracts, we have identified a Notch1-specific destruction signal (N1-Box). …”
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The Cellular Basis for Animal Regeneration by Tanaka, Elly M., Reddien, Peter

“…Recent advances involving cell fate tracking in complex tissues have shed new light on the cellular underpinnings of regeneration in Hydra, planarians, zebrafish, Xenopus, and Axolotl. Planarians accomplish regeneration with use of adult pluripotent stem cells, whereas several vertebrates utilize a collection of lineage-restricted progenitors from different tissues. …”
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Functional Clustering Drives Encoding Improvement in a Developing Brain Network during Awake Visual Learning by Dunfield, Derek, Podgorski, Kaspar, Haas, Kurt

“…Using two-photon calcium imaging to monitor evoked activity in over 100 neurons simultaneously, we investigate network-level changes in the developing Xenopus laevis tectum during visual training with motion stimuli. …”
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Fast Microtubule Dynamics in Meiotic Spindles Measured by Single Imaging: Evidence that the Spindle Environment does not Stabilize Microtubules by Mirny, Leonid A., Mitchison, Timothy J., Maresca, Tom, Ohi, Ryoma, Groen, Aaron, Needleman, Daniel J.

“…We used single molecule imaging to measure tubulin turnover in spindles, and nonspindle assemblies, in Xenopus laevis egg extracts. We observed many events where tubulin molecules spend only a few seconds in polymer and thus are difficult to reconcile with standard models of polymerization dynamics. …”
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Keeping two animal systems in one lab – a frog plus fish case study by Sive, Hazel L.

“…For two decades, my lab has been studying development using two vertebrate animals, the frog Xenopus and the zebrafish, Danio. This has been both productive and challenging. …”
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Formation of a “Pre-mouth Array” from the Extreme Anterior Domain Is Directed by Neural Crest and Wnt/PCP Signaling by Lathrop-Marshall, Hillary, Chen, Justin, Rothman, Alyssa L., Jacox, Laura A., Sive, Hazel L.

“…Here, we identify a ‘‘premouth array’’ in Xenopus that forms soon after the cranial neural crest has migrated to lie on either side of the EAD. …”
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A Neuronal Acetylcholine Receptor Regulates the Balance of Muscle Excitation and Inhibition in Caenorhabditis elegans by Jospin, Maelle, Qi, Yingchuan B., Stawicki, Tamara M., Boulin, Thomas, Schuske, Kim R., Bessereau, Jean-Louis, Jorgensen, Erik M., Jin, Yishi, Horvitz, Howard Robert

“…Expression of these subunits in Xenopus oocytes demonstrates that the functional receptor is comprised of three α-subunits, UNC-38, UNC-63 and ACR-12, and two non–α-subunits, ACR-2 and ACR-3. …”
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Roles of Major Facilitator Superfamily Transporters in Phosphate Response in Drosophila by Bergwitz, Clemens, Rasmussen, Matthew D., DeRobertis, Charles, Wee, Mark J., Sinha, Sumi, Chen, Hway H., Huang, Joanne, Perrimon, Norbert

“…Surprisingly, while we found that RNAi-mediated knockdown of the fly Pho89 ortholog dPit had little effect on the activation of MAPK in Drosophila S2R+ cells by phosphate, two Pho84/SLC17A1–9 MFS orthologs (MFS10 and MFS13) specifically inhibited this response. Further, using a Xenopus oocyte assay, we show that MSF13 mediates uptake of [³³P]-orthophosphate in a sodium-dependent fashion. …”
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Essential roles of fibronectin in the development of the left–right embryonic body plan by Pulina, Maria V., Hou, Shuan-Yu, Mittal, Ashok, Julich, Dorthe, Whittaker, Charlie A., Holley, Scott A., Astrof, Sophie, Whittaker, Charles A., Hynes, Richard O

“…Studies in Xenopus laevis suggested that cell-extracellular matrix (ECM) interactions regulate the development of the left–right axis of asymmetry; however, the identities of ECM components and their receptors important for this process have remained unknown. …”
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The Extreme Anterior Domain Is an Essential Craniofacial Organizer Acting through Kinin-Kallikrein Signaling by Sindelka, Radek, Chen, Justin, Rothman, Alyssa, Dickinson, Amanda J., Jacox, Laura A., Sive, Hazel L.

“…We show that the Kinin-Kallikrein pathway is active in the EAD and necessary for craniofacial development in Xenopus and zebrafish. The mouth failed to form and neural crest (NC) development and migration was abnormal after loss of function (LOF) in the pathway genes kng, encoding Bradykinin (xBdk), carboxypeptidase-N (cpn), which cleaves Bradykinin, and neuronal nitric oxide synthase (nNOS). …”
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