Comparative RNA editing in autistic and neurotypical cerebella by Eran, A., Li, J. B., Vatalaro, K., McCarthy, J., Rahimov, F., Collins, C., Markianos, K., Margulies, David M., Calvo, Sarah E., Kohane, Isaac, Kunkel, Louis M., Brown, Emery N.

“…Using ultra-deep (>1000 × ) sequencing, we quantified the levels of A-to-I editing of 10 synaptic genes in postmortem cerebella from 14 neurotypical and 11 autistic individuals. A high dynamic range of editing levels was detected across individuals and editing sites, from 99.6% to below detection limits. …”
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Chd8 Mutation Leads to Autistic-like Behaviors and Impaired Striatal Circuits by Shetty, Ashwin S., Weisbach, Niels R., Crabtree, Gerald R., Platt, Randall Jeffrey, Zhou, Yang, Slaymaker, Ian, Kim, Jinah, Sharma, Jitendra, Desai, Mitul, Sood, Sabina, Kempton, Hannah R., Feng, Guoping, Zhang, Feng

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Shank3 mutant mice display autistic-like behaviours and striatal dysfunction by Peca, Joao, Feliciano, Catia, Ting, Jonathan T., Wang, Wenting, Wells, Michael F., Venkatraman, Talaignair N., Lascola, Christopher D., Fu, Zhanyan, Feng, Guoping

“…Our findings demonstrate a critical role for SHANK3 in the normal development of neuronal connectivity and establish causality between a disruption in the Shank3 gene and the genesis of autistic-like behaviours in mice.…”
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Lessons from participatory design with adolescents on the autism spectrum by Picard, Rosalind W., Goodwin, Matthew, Hoque, Mohammed Ehasanul, Eckhardt, Micah Rye, El Kaliouby, Rana, Madsen, Miriam A.

“…Through our work developing a system to help autistic adolescents learn to recognize facial expressions, we have learned valuable lessons about software and hardware design issues for this population. …”
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Future affective technology for autism and emotion communication by Picard, Rosalind W.

“…Measurements taken from home and school environments show that extreme overload experienced internally, measured as autonomic nervous system (ANS) activation, may not be visible externally: a person can have a resting heart-rate twice the level of non-autistic peers, while outwardly appearing calm and relaxed. …”
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STX209 (Arbaclofen) for Autism Spectrum Disorders: An 8-Week Open-Label Study by Erickson, Craig A., Veenstra-Vanderweele, Jeremy M., Melmed, Raun D., McCracken, James T., Ginsberg, Lawrence D., Sikich, Linmarie, Scahill, Lawrence, Cherubini, Maryann, Zarevics, Peter, Walton-Bowen, Karen, Carpenter, Randall L., Wang, Paul P., King, Bryan H., Bear, Mark

“…We evaluated its safety, tolerability, and efficacy in non-syndromic autism spectrum disorders, in an 8-week open-label trial enrolling 32 children and adolescents with either Autistic Disorder or Pervasive Developmental Disorder—Not Otherwise Specified, and a score ≥17 on the Aberrant Behavior Checklist (ABC)—Irritability subscale. …”
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Communication Impairments in Mice Lacking Shank1: Reduced Levels of Ultrasonic Vocalizations and Scent Marking Behavior by Wohr, Markus, Roullet, Florence I., Hung, Albert Y., Sheng, Morgan Hwa-Tze, Crawley, Jacqueline N.

“…Candidate genes for autism include the SHANK gene family, as mutations in SHANK2 and SHANK3 have been detected in several autistic individuals. SHANK genes code for a family of scaffolding proteins located in the postsynaptic density of excitatory synapses. …”
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Epigenetic Characterization of the FMR1 Gene and Aberrant Neurodevelopment in Human Induced Pluripotent Stem Cell Models of Fragile X Syndrome by Theriault, Kraig M., Daheron, Laurence, Loring, Jeanne F., Sheridan, Steven, Reis, Surya A., Zhou, Fen, Madison, Jon M., Haggarty, Stephen J.

“…In addition to cognitive deficits, FXS patients exhibit hyperactivity, attention deficits, social difficulties, anxiety, and other autistic-like behaviors. FXS is caused by an expanded CGG trinucleotide repeat in the 5′ untranslated region of the Fragile X Mental Retardation (FMR1) gene leading to epigenetic silencing and loss of expression of the Fragile X Mental Retardation protein (FMRP). …”
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