RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction by Sager, H. B., Dutta, P., Hulsmans, M., Courties, G., Sun, Y., Heidt, T., Vinegoni, C., Borodovsky, A., Fitzgerald, K., Wojtkiewicz, G. R., Iwamoto, Y., Tricot, B., Libby, P., Weissleder, R., Swirski, F. K., Nahrendorf, M., Xing, Yiping, Shaw, Taylor E., Langer, Robert S, Anderson, Daniel Griffith, Khan, Omar Fizal, Kauffman, Kevin John, Dahlman, James E.

“…Simultaneously encapsulating small interfering RNA (siRNA)–targeting intercellular cell adhesion molecules 1 and 2 (Icam1 and Icam2), vascular cell adhesion molecule 1 (Vcam1), and E- and P-selectins (Sele and Selp) into polymeric endothelial-avid nanoparticles reduced post-MI neutrophil and monocyte recruitment into atherosclerotic lesions and decreased matrix-degrading plaque protease activity. …”
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Programmed elimination of cells by caspase-independent cell extrusion in C. elegans by Hatch, Victoria, Denning, Daniel Prudden, Horvitz, Howard Robert

“…PIG-1 promotes shed-cell detachment by preventing the cell-surface expression of cell-adhesion molecules. Our findings reveal a mechanism for apoptotic cell elimination that is fundamentally distinct from that of canonical programmed cell death.…”
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Investigations on the Usefulness of CEACAMs as Potential Imaging Targets for Molecular Imaging Purposes by Heine, Markus, Nollau, Peter, Masslo, Christoph, Nielsen, Peter, Freund, Barbara, Reimer, Rudolph, Hohenberg, Heinrich, Peldschus, Kersten, Ittrich, Harald, Schumacher, Udo, Bruns, Oliver Thomas

“…Members of the carcinoembryonic antigen cell adhesion molecules (CEACAMs) family are the prototype of tumour markers. …”
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Human Vascular Tissue Models Formed from Human Induced Pluripotent Stem Cell Derived Endothelial Cells by Belair, David G., Molenda, James A., Vickerman, Vernella, Lewis, Rachel, Daigh, Christine, Hansen, Tyler D., Mann, David A., Thomson, James A., Griffith, Linda G., Schwartz, Michael P., Murphy, William L., Whisler, Jordan Ari, Kamm, Roger Dale, Valdez Macias, Jorge Luis, Velazquez, Jeremy J.

“…The iPSC-ECs used here were first characterized by expression of endothelial markers and functional properties that included VEGF responsiveness, TNF-α-induced upregulation of cell adhesion molecules (MCAM/CD146; ICAM1/CD54), thrombin-dependent barrier function, shear stress-induced alignment, and 2D and 3D capillary-like network formation in Matrigel. …”
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Label-free biomarker sensing in undiluted serum with suspended microchannel resonators by Brault, Norman D., Jiang, Shaoyi, Von Muhlen, Marcio Goldani, Knudsen, Scott Michael, Manalis, Scott R.

“…Coupled with a reference microcantilever, this approach enables detection of activated leukocyte cell adhesion molecule (ALCAM), a model cancer biomarker, in undiluted serum with a limit of detection of 10 ng/mL.…”
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A role for PVRL4-driven cell-cell interactions in tumorigenesis by Pallasch, Christian, Braun, Christian Joerg, Hemann, Michael, Pavlova, Natalya N., Elia, Andrew E. H., Westbrook, Thomas F., Elledge, Stephen J.

“…A gain of function screen for genes that enable proliferation independently of matrix anchorage identified a cell adhesion molecule PVRL4 (poliovirus-receptor-like 4), also known as Nectin-4. …”
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Macrophages retain hematopoietic stem cells in the spleen via VCAM-1 by Dutta, Partha, Hoyer, Friedrich Felix, Grigoryeva, Lubov S., Sager, Hendrik B., Leuschner, Florian, Courties, Gabriel, Borodovsky, Anna, Novobrantseva, Tatiana I., Ruda, Vera M., Fitzgerald, Kevin, Iwamoto, Yoshiko, Wojtkiewicz, Gregory, Sun, Yuan, Da Silva, Nicolas, Libby, Peter, Swirski, Filip K., Weissleder, Ralph, Nahrendorf, Matthias, Anderson, Daniel Griffith

“…Here, we show that red pulp vascular cell adhesion molecule 1 (VCAM-1)[superscript +] macrophages are essential to extramedullary myelopoiesis because these macrophages use the adhesion molecule VCAM-1 to retain HSCs in the spleen. …”
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Microenvironmental regulation of the sinusoidal endothelial cell phenotype in vitro by March, Sandra, Hui, Elliot E., Underhill, Gregory, Khetani, Salman R., Bhatia, Sangeeta N.

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Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats by Jaenisch, Rudolf, Hargus, Gunnar, Cooper, Oliver, Deleidi, Michela, Levy, Adam, Lee, Kristen N., Marlow, Elizabeth, Yow, Alyssa, Soldner, Frank, Hockemeyer, Dirk, Hallett, Penelope J., Osborn, Teresia, Isacson, Ole

“…We next applied FACS for the neural cell adhesion molecule NCAM on differentiated PDiPS cells before transplantation, which resulted in surviving DA neurons with functional effects on amphetamine-induced rotational asymmetry in a 6-OHDA animal model of PD. …”
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Abrogation of antibody-induced arthritis in mice by a self-activating viridin prodrug and association with impaired neutrophil and endothelial cell function by Stangenberg, Lars, Ellson, Chris, Cortez-Retamozo, Virna, Ortiz-Lopez, Adriana, Yuan, Hushan, Blois, Joseph, Smith, Ralph A., Weissleder, Ralph, Benoist, Christophe, Mathis, Diane, Josephson, Lee, Mahmood, Umar, Yaffe, Michael B

“…Endothelial cell activation by tumor necrosis factor α was impeded by SAV, as measured by the expression of vascular cell adhesion molecule. Crucial neutrophil functions, such as generation of reactive oxygen species and degranulation of protease-laden vesicles, were decreased by SAV administration. …”
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CEACAM1 regulates TIM-3-mediated tolerance and exhaustion by Huang, Yu-Hwa, Zhu, Chen, Kondo, Yasuyuki, Anderson, Ana C., Gandhi, Amit, Russell, Andrew, Dougan, Stephanie K., Petersen, Britt-Sabina, Melum, Espen, Pertel, Thomas, Clayton, Kiera L., Raab, Monika, Chen, Qiang, Beauchemin, Nicole, Yazaki, Paul J., Pyzik, Michal, Ostrowski, Mario A., Glickman, Jonathan N., Rudd, Christopher E., Franke, Andre, Petsko, Gregory A., Kuchroo, Vijay K., Blumberg, Richard S., Ploegh, Hidde

“…Here we show that TIM-3 is co-expressed and forms a heterodimer with carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1), another well-known molecule expressed on activated T cells and involved in T-cell inhibition[superscript 6, 7, 8, 9, 10]. …”
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