Genetics of germ cell development by Lesch, Bluma J., Page, David C

“…The germ line represents a continuous cellular link between generations and between species, but the germ cells themselves develop in a specialized, organism-specific context. …”
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Licensing of Primordial Germ Cells for Gametogenesis Depends on Genital Ridge Signaling by Hu, Yueh-Chiang, Nicholls, Peter K., Soh, Ying Qi Shirleen, Daniele, Joseph R., Junker, Jan Philipp, van Oudenaarden, Alexander, Page, David C

“…In mouse embryos at mid-gestation, primordial germ cells (PGCs) undergo licensing to become gametogenesis-competent cells (GCCs), gaining the capacity for meiotic initiation and sexual differentiation. …”
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A widely employed germ cell marker is an ancient disordered protein with reproductive functions in diverse eukaryotes by Carmell, Michelle A, Dokshin, Gregoriy A, Skaletsky, Helen, Hu, Yueh-Chiang, van Wolfswinkel, Josien C, Igarashi, Kyomi J, Bellott, Daniel W, Nefedov, Michael, Enders, George C, Uversky, Vladimir N, Mello, Craig C, Reddien, Peter, Page, David C

“…We report an ancient family of GCNA (germ cell nuclear antigen) proteins that arose in the earliest eukaryotes, and feature a rapidly evolving intrinsically disordered region (IDR). …”
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Mir-290–295 deficiency in mice results in partially penetrant embryonic lethality and germ cell defects by Medeiros, Lea Ann, Dennis, Lucas M., Gill, Mark E., Houbaviy, Hristo, Markoulaki, Styliani, Fu, Dongdong, White, Amy C., Kirak, Oktay, Sharp, Phillip A., Jaenisch, Rudolf, Page, David C

“…Male mir-290–295−/− mice, due to the extended proliferative lifespan of their germ cells, are able to recover from this initial germ cell loss and are fertile. …”
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The Ligand Binding Domain of GCNF Is Not Required for Repression of Pluripotency Genes in Mouse Fetal Ovarian Germ Cells by Okumura, Leah M., Lesch, Bluma J., Page, David C.

“…In mice, successful development and reproduction require that all cells, including germ cells, transition from a pluripotent to a differentiated state. …”
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Periodic retinoic acid–STRA8 signaling intersects with periodic germ-cell competencies to regulate spermatogenesis by Endo, Tsutomu, Romer, Katherine A., Anderson, Ericka L., Baltus, Andrew E., de Rooij, Dirk G., Page, David C

“…Competencies for both transitions begin while RA levels are low, so that the germ cells respond as soon as RA levels rise. Together with other findings, our results demonstrate that periodic RA–STRA8 signaling intersects with periodic germ-cell competencies to regulate two distinct, cell-type-specific responses: spermatogonial differentiation and meiotic initiation. …”
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Licensing of gametogenesis, dependent on RNA binding protein DAZL, as a gateway to sexual differentiation of fetal germ cells by Gill, Mark E., Hu, Yueh-Chiang, Lin, Yanfeng, Page, David C

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A set of genes critical to development is epigenetically poised in mouse germ cells from fetal stages through completion of meiosis by Lesch, Bluma J., Dokshin, Gregoriy A., Young, Richard A., McCarrey, John R., Page, David C

“…In multicellular organisms, germ cells carry the hereditary material from one generation to the next. …”
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Repair shielding of platinum-DNA lesions in testicular germ cell tumors by high-mobility group box protein 4 imparts cisplatin hypersensitivity by Awuah, Samuel, Riddell, Imogen Anne, Lippard, Stephen J.

“…Cisplatin is the most commonly used anticancer drug for the treatment of testicular germ cell tumors (TGCTs). The hypersensitivity of TGCTs to cisplatin is a subject of widespread interest. …”
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Blimp1 Expression Predicts Embryonic Stem Cell Development In Vitro by Chu, Li-Fang, Surani, M. Azim, Jaenisch, Rudolf, Zwaka, Thomas P.

“…Single-cell gene expression profiling indicated that many of these Blimp1-positive cells coexpress other genes typically associated with early germ cell specification. When genetically traced in vitro, these cells acquired properties normally associated with primordial germ cells. …”
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Poised chromatin in the mammalian germ line by Lesch, B. J., Page, David C

“…We hypothesize that the poised chromatin state is essential for germ cell identity and function. We propose three roles for poised chromatin in the mammalian germ line: prevention of DNA methylation, maintenance of germ cell identity and preparation for totipotency. …”
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The C. elegans MicroRNA mir-71 Acts in Neurons to Promote Germline-Mediated Longevity through Regulation of DAF-16/FOXO by Boulias, Konstantinos, Horvitz, Howard Robert

“…The life span of Caenorhabditis elegans is controlled by signaling between the germline and the soma. Germ cell removal extends life span by triggering the activation of the DAF-16/FOXO transcription factor in the intestine. …”
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Tumor suppressor gene Rb is required for self-renewal of spermatogonial stem cells in mice by Hu, Yueh-Chiang, de Rooij, Dirk G., Page, David C

“…We conditionally disrupted the Rb gene in mouse germ cells in vivo and discovered unanticipated consequences for GFRa1-protein-expressing A[subscript single] (GFRa1[superscript +] A[subscript s]) spermatogonia, the major source of male germ-line stem cells. …”
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Different Roles for Tet1 and Tet2 Proteins in Reprogramming-Mediated Erasure of Imprints Induced by EGC Fusion by Piccolo, Francesco M., Bagci, Hakan, Brown, Karen E., Landeira, David, Soza-Ried, Jorge, Feytout, Amelie, Mooijman, Dylan, Hajkova, Petra, Leitch, Harry G., Tada, Takashi, Kriaucionis, Skirmantas, Dawlaty, Meelad M., Jaenisch, Rudolf, Merkenschlager, Matthias, Fisher, Amanda G.

“…Differential DNA methylation at imprinted control regions (ICRs) is established in gametes and, although largely preserved through development, can be experimentally reset by fusing somatic cells with embryonic germ cell (EGC) lines. Here, we show that the Ten-Eleven Translocation proteins Tet1 and Tet2 participate in the efficient erasure of imprints in this model system. …”
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Meiosis I chromosome segregation is established through regulation of microtubule–kinetochore interactions by Miller, Matthew P., Unal, Elcin, Brar, Gloria A., Amon, Angelika B

“…Determining how this unusual chromosome segregation behavior is established is central to understanding germ cell development. Here we show that preventing microtubule–kinetochore interactions during premeiotic S phase and prophase I is essential for establishing the meiosis I chromosome segregation pattern. …”
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Retinoic Acid Activates Two Pathways Required for Meiosis in Mice by Koubova, Jana, Hu, Yueh-Chiang, Bhattacharyya, Tanmoy, Soh, Ying Qi Shirleen, Gill, Mark E., Goodheart, Mary L., Hogarth, Cathryn A., Griswold, Michael D., Page, David C

“…Further, RA induction of Rec8, like that of Stra8, requires the germ-cell-intrinsic competence factor Dazl. Our findings strengthen the importance of RA and Dazl in the meiotic transition, provide important details about the Stra8 pathway, and open avenues to investigate early meiosis through analysis of Rec8 induction and function.…”
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MSY Breakpoint Mapper, a database of sequence-tagged sites useful in defining naturally occurring deletions in the human Y chromosome by Lange, Julian, Skaletsky, Helen, Bell, George W., Page, David C

“…Y chromosome deletions arise frequently in human populations, where they cause sex reversal and Turner syndrome and predispose individuals to infertility and germ cell cancer. Knowledge of the nucleotide sequence of the male-specific region of the Y chromosome (MSY) makes it possible to precisely demarcate such deletions and the repertoires of genes lost, offering insights into mechanisms of deletion and the molecular etiologies of associated phenotypes. …”
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Meioc maintains an extended meiotic prophase I in mice by Soh, Ying Qi Shirleen, Mikedis, Maria M., Kojima, Mina, Godfrey, Alexander Kamitsuka, Page, David C, de Rooij, Dirk G.

“…In mice, Meioc is expressed in male and female germ cells upon initiation of and throughout meiotic prophase I. …”
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Binding Interaction of HMGB4 with Cisplatin-Modified DNA by Park, Semi, Lippard, Stephen J.

“…The putative role of HMGB4 in the mechanism of action of cisplatin, and especially its potential relevance to the hypersensitivity of testicular germ cell tumors to cisplatin, are discussed.…”
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The Translational Regulators GCN-1 and ABCF-3 Act Together to Promote Apoptosis in C. elegans by Hirose, Takashi, Horvitz, Howard Robert

“…GCN-1 and ABCF-3 are not obviously involved in the physiological germ-cell deaths that occur during oocyte maturation. …”
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