Prenatal exposure of mice to the human liver carcinogen aflatoxin B by Thiantanawat, Apinya, Egner, Patricia A., Groopman, John D., Chawanthayatham, Supawadee, Wogan, Gerald N, Croy, Robert G, Essigmann, John M

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A Microscale Human Liver Platform that Supports the Hepatic Stages of Plasmodium falciparum and vivax by March-Riera, Sandra, Ng, Shengyong, Velmurugan, Soundarapandian, Galstian, Ani, Shan, Jing, Logan, David J., Carpenter, Anne E., Thomas, David, Sim, B. Kim Lee, Mota, Maria M., Hoffman, Stephen L.

“…Here, we establish the liver stages for both Plasmodium falciparum and Plasmodium vivax in a microscale human liver platform composed of cryopreserved, micropatterned human primary hepatocytes surrounded by supportive stromal cells. …”
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Metabolite profiling and pharmacokinetic evaluation of hydrocortisone in a perfused 3D human liver bioreactor by Sarkar, Ujjal, Rivera-Burgos, Dinelia, Large, Emma M., Hughes, David J., Kodihalli, Ravindra, Dyer, Rachel Lee, Ebrahimkhani, Mohammad Reza, Wishnok, John S., Griffith, Linda G., Tannenbaum, Steven Robert

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Integrated Assessment of Diclofenac Biotransformation, Pharmacokinetics, and Omics-Based Toxicity in a Three-Dimensional Human Liver-Immunocompetent Coculture System by Large, Emma, Hughes, David J., Sarkar, Ujjal, Ravindra, Kodihalli C., Young, Carissa L., Rivera-Burgos, Dinelia, Yu, Jiajie, Cirit, Murat, Wishnok, John S, Lauffenburger, Douglas A, Griffith, Linda G, Tannenbaum, Steven R

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Adenovirus-Mediated Somatic Genome Editing of Pten by CRISPR/Cas9 in Mouse Liver in Spite of Cas9-Specific Immune Responses by Wang, Dan, Mou, Haiwei, Li, Shaoyong, Li, Yingxiang, Hough, Soren, Tran, Karen, Li, Jia, Sontheimer, Erik J., Weng, Zhiping, Gao, Guangping, Xue, Wen, Yin, Hao, Anderson, Daniel Griffith

“…Nonalcoholic steatohepatitis (NASH) is a prevalent human liver disease characterized by excessive fat accumulation in the liver. …”
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Towards a Humanized Mouse Model of Liver Stage Malaria Using Ectopic Artificial Livers by Ng, Shengyong, March, Sandra, Galstian, Ani, Gural, Nil, Stevens, Kelly R., Mota, Maria M., Bhatia, Sangeeta N., March-Riera, Sandra, Prado, Mariana, Bhatia, Sangeeta N

“…Given ethical concerns and costs associated with non‐human primate models, humanized mouse models containing chimeric human livers offer a valuable alternative as small animal models of liver stage human malaria. …”
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A microfabricated 3D tissue engineered "Liver on a Chip" : information content assays for in vitro drug metabolism studies by Sivaraman, Anand, 1977-

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Engineering liver by Griffith, Linda G., Wells, Alan, Stolz, Donna B.

“…An explosion of micro- and nanofabrication, biomaterials, microfluidic, and other technologies potentially affords unprecedented opportunity to create microphysiological models of the human liver, but engineering design principles for how to deploy these tools effectively toward specific applications, including how to define the essential constraints of any given application (available sources of cells, acceptable cost, and user-friendliness), are still emerging. …”
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Humanized mice with ectopic artificial liver tissues by Thomas, David K., Chen, Alice, Ong, Luvena L., Schwartz, Robert E., Golub, Todd, Bhatia, Sangeeta N

“…Mice transplanted with HEALs exhibit humanized liver functions persistent for weeks, including synthesis of human proteins, human drug metabolism, drug–drug interaction, and drug-induced liver injury. …”
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Characterisation of liver pathogenesis, human immune responses and drug testing in a humanised mouse model of HCV infection by Keng, Choong Tat, Sze, Ching Wooen, Zheng, Dahai, Zheng, Zhiqiang, Yong, Kylie Su Mei, Tan, Shu Qi, Ong, Jessica Jie Ying, Tan, Sue Yee, Loh, Eva, Upadya, Megha Haridas, Kuick, Chik Hong, Hotta, Hak, Lim, Seng Gee, Tan, Thiam Chye, Chang, Kenneth T E, Hong, Wanjin, Chen, Jianzhu, Tan, Yee-Joo, Chen, Qingfeng

“…Design Recently, we have established human liver cells with a matched human immune system in NOD-scid Il2rg−/− (NSG) mice (HIL mice). …”
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Hypoxia promotes liver stage malaria infection in primary human hepatocytes in vitro by Ng, Shengyong, March-Riera, Sandra, Galstian, Ani, Hanson, Kirsten, Carvalho, Tania, Mota, Maria M., Bhatia, Sangeeta N

“…We developed a microscale human liver platform comprised of precisely patterned primary human hepatocytes and nonparenchymal cells (MPCC) to model liver stage malaria, but the oxygen concentrations are typically higher in the in vitro liver platform than anywhere along the hepatic sinusoid. …”
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Gut microbes define liver cancer risk in mice exposed to chemical and viral transgenic hepatocarcinogens by Rogers, Arlin B., Fry, Rebecca C., Dedon, Peter C., Tannenbaum, Steven Robert, Schauer, David B., Essigmann, John M., McFaline, Jose Luis, Williams, Michelle V., Doernte, A. L., Fiala, Jeannette Louise Allen, Raczynski, Arkadiusz R., Theve, E. J., Feng, Yan, Fox, James G., Lemon, S. M., Weinman, S. A.

“…These results have implications for human liver cancer risk assessment and prevention.…”
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Hepatitis C Virus Infection and Hepatic Stellate Cell Activation Downregulate miR-29: miR-29 Overexpression Reduces Hepatitis C Viral Abundance in Culture by Bandyopadhyay, Sarmistha, Friedman, Robin Carl, Marquez, Rebecca T., Keck, Kathy, Kong, Benjamin, Icardi, Michael S., Brown, Kyle E., Schmidt, Warren N., Wang, Yulei, McCaffrey, Anton P., Burge, Christopher B

“…TaqMan miRNA profiling identified 12 miRNA families differentially expressed between chronically HCV-infected human livers and uninfected controls. To identify pathways affected by miRNAs, we developed a new algorithm (pathway analysis of conserved targets), based on the probability of conserved targeting. …”
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