Transplantation of human islets without immunosuppression by Colton, Clark K., Ludwig, Barbara, Reichel, Andreas, Steffen, Anja, Zimerman, Baruch, Schally, Andrew V., Block, Norman L., Ludwig, Stefan, Kersting, Stephan, Bonifacio, Ezio, Solimena, Michele, Gendler, Zohar, Rotem, Avi, Barkai, Uriel, Bornstein, Stefan R.

“…Its current stringent restriction to patients with critical metabolic lability is justified by the long-term need for immunosuppression and a persistent shortage of donor organs. …”
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Microneedle‐mediated Delivery of Immunomodulators Restores Immune Privilege in Hair Follicles and Reverses Immune‐Mediated Alopecia by Younis, Nour, Puigmal, Núria, Kurdi, Abdallah El, Badaoui, Andrew, Zhang, Dongliang, Morales, Claudia, Saad, Anis, Cruz, Diane, Rahy, Nadim Al, Daccache, Andrea, Huerta, Triana, Deban, Christa, Halawi, Ahmad, Choi, John, Dosta, Pere, Lian, Christine, Artzi, Natalie, Azzi, Jamil R.

“…Disorders in the regulatory arm of the adaptive immune system result in autoimmune‐mediated diseases. While systemic immunosuppression is the prevailing approach to manage them, it fails to achieve long‐lasting remission due to concomitant suppression of the regulatory arm and carries the risk of heightened susceptibility to infections and malignancies. …”
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Long-term glycemic control using polymer-encapsulated human stem cell–derived beta cells in immune-competent mice by Gürtler, Mads, Millman, Jeffrey R, Pagliuca, Felicia W, McGarrigle, James J, Bochenek, Matthew A, Hollister-Lock, Jennifer, Oberholzer, Jose, Greiner, Dale L, Weir, Gordon C, Melton, Douglas A, Vegas, Arturo, Veiseh, Omid, Bader, Andrew, Doloff, Joshua C, Li, Jie, Chen, Michael, Olejnik, Karsten, Tam, Hok Hei, Jhunjhunwala, Siddharth, Langan, Erin, Aresta-Dasilva, Stephanie K, Gandham, Srujan Kumar, Langer, Robert S, Anderson, Daniel Griffith

“…These implants induced glycemic correction without any immunosuppression until their removal at 174 d after implantation. …”
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Improvement of islet function in a bioartificial pancreas by enhanced oxygen supply and growth hormone releasing hormone agonist by Ludwig, Barbara, Rotem, Avi, Schmid, Janine, Weir, Gordon C., Colton, Clark K., Brendel, Mathias D., Neufeld, Tova, Block, Norman L., Yavriyants, Karina, Steffen, Anja, Ludwig, Stefan, Chavakis, Triantafyllos, Reichel, Andreas, Azarov, Dmitri, Zimermann, Baruch, Maimon, Shiri, Balyura, Maria, Rozenshtein, Tania, Shabtay, Noa, Vardi, Pnina, Bloch, Konstantin, de Vos, Paul, Schally, Andrew V., Bornstein, Stefan R., Barkai, Uriel

“…However, critical shortage of donor organs, gradual loss in graft function over time, and chronic need for immunosuppression limit the indication for islet transplantation to a small group of patients. …”
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Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors by Martin, John Daniel, Jain, Saloni R., Stylianopoulosa, Triantafyllos, Chauhana, Vikash P., Bardeesy, Nabeel, Diop-Frimpong, Benjamin, Stylianopoulos, Triantafyllos, Smith, Barbara L., Ferrone, Cristina R., Hornicek, Francis J., Boucher, Yves, Munn, Lance L., Jain, Rakesh K.

“…Reduced blood flow, in turn, leads to hypoxia, which promotes tumor progression, immunosuppression, inflammation, invasion, and metastasis and lowers the efficacy of chemo-, radio-, and immunotherapies. …”
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Induction of potent anti-tumor responses while eliminating systemic side effects via liposome-anchored combinatorial immunotherapy by Kwong, Brandon, Liu, Haipeng, Irvine, Darrell J

“…Immunostimulatory therapies that activate immune response pathways are of great interest for overcoming the immunosuppression present in advanced tumors. Agonistic anti-CD40 antibodies and CpG oligonucleotides have previously demonstrated potent, synergistic anti-tumor effects, but their clinical use even as monotherapies is hampered by dose-limiting inflammatory toxicity provoked upon systemic exposure. …”
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The Efficacy of an Immunoisolating Membrane System for Islet Xenotransplantation in Minipigs by Neufeld, Tova, Ludwig, Barbara, Barkai, Uriel, Weir, Gordon C., Colton, Clark K., Evron, Yoav, Balyura, Maria, Yavriyants, Karina, Zimermann, Baruch, Azarov, Dmitri, Maimon, Shiri, Shabtay, Noa, Rozenshtein, Tania, Lorber, Dana, Steffen, Anja, Willenz, Udi, Bloch, Konstantin, Vardi, Pnina, Taube, Ran, de Vos, Paul, Lewis, Eli C., Bornstein, Stefan R., Rotem, Avi

“…We demonstrated a persistent graft function and restoration of normoglycemia without the need for immunosuppressive therapy. This concept could potentially offer an attractive strategy for a more widespread islet replacement therapy that would restore endogenous insulin secretion in diabetic patients without the need for immunosuppressive drugs and may even open up an avenue for safe utilization of xenogeneic islet donors.…”
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Tetrandrine identified in a small molecule screen to activate mesenchymal stem cells for enhanced immunomodulation by Yang, Zijiang, Concannon, John, Seyb, Kathleen, Mortensen, Luke J., Ranganath, Sudhir, Gu, Fangqi, Levy, Oren, Martyn, Keir, Zhao, Weian, Glicksman, Marcie A., Ng, Kelvin Songyu, Tong, Zhixiang, Lin, Charles, Karp, Jeffrey Michael

“…Pre-treatment or priming of mesenchymal stem cells (MSC) prior to transplantation can significantly augment the immunosuppressive effect of MSC-based therapies. In this study, we screened a library of 1402 FDA-approved bioactive compounds to prime MSC. …”
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Pathogen boosted adoptive cell transfer immunotherapy to treat solid tumors by Xin, Gang, Schauder, David M., Jing, Weiqing, Jiang, Aimin, Johnson, Bryon, Cui, Weiguo, Joshi, Nik

“…Because of insufficient migration and antitumor function of transferred T cells, especially inside the immunosuppressive tumor microenvironment (TME), the efficacy of adoptive cell transfer (ACT) is much curtailed in treating solid tumors. …”
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In vivo targeting of adoptively transferred T-cells with antibody- and cytokine-conjugated liposomes by Zheng, Yiran, Stephan, Matthias T., Gai, S. Annie, Abraham, Wuhbet, Shearer, Adrianne, Zheng, Yiran, Irvine, Darrell J

“…A major limitation of this promising approach is the rapid loss of ACT T-cell effector function in vivo due to the highly immunosuppressive environment in tumors. Protection of T-cells from immunosuppressive signals can be achieved by systemic administration of supporting adjuvant drugs such as interleukins, chemotherapy, and other immunomodulators, but these adjuvant treatments are often accompanied by serious toxicities and may still fail to optimally stimulate lymphocytes in all tumor and lymphoid compartments. …”
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Stimulation of dendritic cells enhances immune response after photodynamic therapy by Mroz, Pawel, Castano, Ana P., Hamblin, Michael R.

“…Instead of DC that can become mature and activated and have a potent antigen-presenting and immune stimulating phenotype, immature dendritic cells (iDC) are often found in tumors and are part of an immunosuppressive milieu including regulatory T-cells and immunosuppressive cytokines such as TGF-beta and IL10. …”
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RNAi nanomaterials targeting immune cells as an anti-tumor therapy: the missing link in cancer treatment? by Conde, Joao, Arnold, Christina E., Tian, Furong, Artzi, Natalie

“…RNAi nanomaterials can act as a Trojan horse which delivers siRNAs against immunosuppressive factors and reverses the regulatory activity of tumor immune cells residing in the tumor microenvironment. …”
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A Pt(IV) Pro-drug Preferentially Targets Indoleamine-2,3-dioxygenase, Providing Enhanced Ovarian Cancer Immuno-Chemotherapy by Awuah, Samuel, Zheng, Yaorong, Bruno, Peter Michael, Hemann, Michael, Lippard, Stephen J.

“…Expression of indoleamine-2,3-dioxygenase (IDO), an immunosuppressive enzyme in human tumors, leads to immune evasion and tumor tolerance. …”
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Direct Reprogramming of Fibroblasts into Embryonic Sertoli-like Cells by Defined Factors by Buganim, Yosef, Itskovich, Elena, Hu, Yueh-Chiang, Ganz, Kibibi, Sarkar, Sovan, Fu, Dongdong, Welstead, G. Grant, Jaenisch, Rudolf, Cheng, Albert Wu, Page, David C

“…Their essential roles in male fertility along with their immunosuppressive and neurotrophic properties make them an attractive cell type for therapeutic applications. …”
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In vivo discovery of immunotherapy targets in the tumour microenvironment by Zhou, Penghui, Shaffer, Donald R., Alvarez Arias, Diana A., Nakazaki, Yukoh, Pos, Wouter, Torres, Alexis J., Cremasco, Viviana, Dougan, Stephanie K., Cowley, Glenn S., Elpek, Kutlu, Brogdon, Jennifer, Lamb, John, Turley, Shannon J., Ploegh, Hidde, Root, David E., Dranoff, Glenn, Hacohen, Nir, Cantor, Harvey, Wucherpfennig, Kai W., Love, John C

“…However, the regulatory switches controlling T-cell function in immunosuppressive tumours are not well understood. Here we show that such inhibitory mechanisms can be systematically discovered in the tumour microenvironment. …”
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Colonic tuberculosis in an immunocompetent patient by Zubieta-O’Farrill, Gregorio, Gonzalez-Sanchez, Carlos, Villanueva-Saenz, Eduardo, Donoghue, Jacob Alexander, Castillo-Calcaneo, Juan de Dios del

“…DISCUSSION: The incidence and the severity of intestinal TB are increased in immunosuppressed patients and more rapidly progress due to deficient immune response. …”
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Polymeric synthetic nanoparticles for the induction of antigen-specific immunological tolerance by Maldonado, Roberto A., LaMothe, Robert A., Ferrari, Joseph D., Zhang, Ai-Hong, Rossi, Robert J., Kolte, Pallavi N., Griset, Aaron P., O'Neil, Conlin P., Altreuter, David H., Browning, Erica A., Johnston, Lloyd P. M., Farokhzad, Omid C., Scott, David W., von Andrian, Ulrich H., Kishimoto, Takashi Kei, Langer, Robert S

“…Current treatments to control pathological or unwanted immune responses often use broadly immunosuppressive drugs. New approaches to induce antigen-specific immunological tolerance that control both cellular and humoral immune responses are desirable. …”
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Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses by Cochran, Jennifer R, Moynihan, Kelly Dare, Opel, Cary Francis, Szeto, Gregory, Tzeng, Alice, Zhu, Eric Franklin, Engreitz, Jesse Michael, Williams, Robert T., Rakhra, Kavya, Zhang, Michael H, Rothschilds, Adrienne Marie, Kumari, Sudha, Kelly, Ryan Lewis, Kwan, Byron Hua, Abraham, Wuhbet, Hu, Kevin, Mehta, Naveen, Kauke, Monique Jacqueline, Suh, Heikyung, Lauffenburger, Douglas A, Wittrup, Karl Dane, Irvine, Darrell J

“…This suboptimal outcome is probably due in part to the complex network of immunosuppressive pathways present in advanced tumors, which are unlikely to be overcome by intervention at a single signaling checkpoint. …”
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Similar Risk of Depression and Anxiety Following Surgery or Hospitalization for Crohn's Disease and Ulcerative Colitis by Ananthakrishnan, Ashwin N., Gainer, Vivian, Cai, Tianxi, Perez, Raul Guzman, Cheng, Su-Chun, Savova, Guergana, Chen, Pei, Szolovits, Peter, Xia, Zongqi, De Jager, Philip L., Shaw, Stanley, Churchill, Susanne, Karlson, Elizabeth W., Kohane, Isaac, Perlis, Roy H., Plenge, Robert M., Murphy, Shawn N., Liao, Katherine P.

“…Female gender, comorbidity, immunosuppressant use, perianal disease, stoma surgery, and early surgery within 3 years of care predicted depression after CD surgery; only the female gender and comorbidity predicted depression in UC patients. …”
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Helicobacter pylori Eradication in Patients with Immune Thrombocytopenic Purpura: A Review and the Role of Biogeography by Beck, Paul L., Frydman, Galit, Davis, Nicholas K., Fox, James G

“…Traditional treatments of ITP have been largely empirical, involving the use of immunosuppressive agents and immunoglobulin therapy. However, based on the findings of clinical reports emerging over the past 20 years, health organizations around the world increasingly suggest the detection and eradication of H. pylori as a treatment for ITP. …”
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