Integrin Signaling Switches the Cytoskeletal and Exocytic Machinery that Drives Neuritogenesis by Gupton, Stephanie L., Gertler, Frank

“…A second mechanism occurs in the presence of laminin through integrin-dependent activation of FAK and src, and utilizes coordinated activity of the Arp2/3 complex and VAMP7-mediated exocytosis. …”
Get full text
Get full text

Integrin Signaling Switches the Cytoskeletal and Exocytic Machinery that Drives Neuritogenesis by Gupton, Stephanie L., Gertler, Frank

“…A second mechanism occurs in the presence of laminin through integrin-dependent activation of FAK and src and uses coordinated activity of the Arp2/3 complex and VAMP7-mediated exocytosis. …”
Get full text
Get full text

Tumor Angiogenesis in the Absence of Fibronectin or Its Cognate Integrin Receptors by Begum, Shahinoor, Murphy, Patrick Andries, Hynes, Richard O

“…Binding of α5β1 and αvβ3/β5 integrin receptors on the endothelium to their fibronectin substrate in the extracellular matrix has been targeted as a possible means of blocking tumor angiogenesis and tumor growth. …”
Get full text
Get full text

Alpha 5 Integrin Mediates Osteoarthritic Changes in Mouse Knee Joints by Candela, Maria Elena, Gunawardena, Aruni T., Zhang, Kairui, Cantley, Leslie, Yasuhara, Rika, Usami, Yu, Francois, Noelle, Iwamoto, Masahiro, van der Flier, Arjan, Zhang, Yejia, Qin, Ling, Enomoto-Iwamoto, Motomi, Wang, Chao, 1972-, Han, Lin, Ph. D. Massachusetts Institute of Technology

“…We hypothesized that α5 integrin signaling is involved in pathogenesis of OA. …”
Get full text

Nanoparticle-formulated siRNA targeting integrins inhibits hepatocellular carcinoma progression in mice by Yin, Hao, Zeigerer, Anja, Nonaka, Hidenori, Zerial, Marino, Koteliansky, Victor, Anderson, Daniel Griffith, Ruda, Vera, Bogorad, Roman

“…Integrins play an important role during development, regulating cell differentiation, proliferation and survival. …”
Get full text
Get full text
Get full text

Acidic Extracellular pH Promotes Activation of Integrin [alpha]v[beta]3 by Paradise, Ranjani K., Lauffenburger, Douglas A., Van Vliet, Krystyn J.

“…Here, we examine the role of acidic extracellular pH in regulating activation of integrin [alpha]v[beta]3. Through computational molecular dynamics simulations, we find that acidic extracellular pH promotes opening of the [alpha]v[beta]3 headpiece, indicating that acidic pH can thereby facilitate integrin activation. …”
Get full text
Get full text

Interaction between integrin α5 and PDE4D regulates endothelial inflammatory signalling by Yun, Sanguk, Budatha, Madhusudhan, Coon, Brian G., Cameron, Ryan T., Baillie, George, Schwartz, Martin A., Langer, Robert S, Anderson, Daniel Griffith, Dahlman, James E.

“…To investigate how fibronectin modulates inflammation in arteries, we replaced the cytoplasmic tail of the fibronectin receptor integrin α5 with that of the collagen/laminin receptor integrin α2. …”
Get full text
Get full text
Get full text

Mena binds α5 integrin directly and modulates α5β1 function by Gupton, Stephanie L., Riquelme, Daisy Noelia, Hughes-Alford, Shannon Kay, Tadros, Jenny, Rudina, Shireen S., Hynes, Richard O., Lauffenburger, Douglas A., Gertler, Frank

“…We find that Mena forms an adhesion-regulated complex with α5β1 integrin, a fibronectin receptor involved in cell adhesion, motility, fibronectin fibrillogenesis, signaling, and growth factor receptor trafficking. …”
Get full text
Get full text
Get full text
Get full text

In Vivo RNAi Screening Identifies a Leukemia-Specific Dependence on Integrin Beta 3 Signaling by Miller, Peter G., Al-Shahrour, Fatima, Hartwell, Kimberly A., Chu, Lisa P., Jaras, Marcus, Puram, Rishi V., Puissant, Alexandre, Callahan, Kevin P., Ashton, John, McConkey, Marie, Poveromo, Luke P., Cowley, Glenn S., Kharas, Michael G., Labelle, Myriam, Shterental, Sebastian, Fujisaki, Joji, Silberstein, Lev, Alexe, Gabriela, Al-Hajj, Muhammad A., Shelton, Christopher A., Armstrong, Scott A., Root, David E., Scadden, David T., Mukherjee, Siddhartha, Stegmaier, Kimberly, Jordan, Craig T., Ebert, Benjamin L., Hynes, Richard O

“…We used an in vivo small hairpin RNA (shRNA) screening approach to identify genes that are essential for MLL-AF9 acute myeloid leukemia (AML). We found that Integrin Beta 3 (Itgb3) is essential for murine leukemia cells in vivo and for human leukemia cells in xenotransplantation studies. …”
Get full text
Get full text

αvβ3 integrin spatially regulates VASP and RIAM to control adhesion dynamics and migration by Gertler, Frank, Worth, Daniel C., Hodivala-Dilke, Kairbaan, Robinson, Stephen D., King, Samantha J., Morton, Penny E., Humphries, Martin J., Parsons, Maddy

“…Integrins are fundamental to the control of protrusion and motility in adherent cells. …”
Get full text
Get full text

An angiogenic role for the α5β1 integrin in promoting endothelial cell proliferation during cerebral hypoxia by Li, Longxuan, Welser-Alves, Jennifer, van der Flier, Arjan, Boroujerdi, Amin, Milner, Richard, Hynes, Richard O

“…In the hypoxic adult central nervous system (CNS), fibronectin is induced on angiogenic vessels, and endothelial cells show strong induction of the two fibronectin receptors α5β1 and αvβ3 integrins. In a previous study, we found that the αvβ3 integrin is dispensable for hypoxic-induced cerebral angiogenesis, but a role for the endothelial α5β1 integrin was suggested. …”
Get full text
Get full text

Integrin beta(1)-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs by Shibue, Tsukasa, Weinberg, Robert A

“…Activation of FAK in these metastatic cells depends on expression of the β1 subunit of integrins, and proliferation of these cells after extravasation in the lungs is diminished by knocking down the expression of either FAK or integrin β1. …”
Get full text
Get full text

α5 and αv integrins cooperate to regulate vascular smooth muscle and neural crest functions in vivo by Turner, Christopher J., Badu-Nkansah, Kwabena, Crowley, Denise G., van der Flier, Arjan, Hynes, Richard O

“…The RGD-binding α5 and αv integrins have been shown to be key regulators of vascular smooth muscle cell (vSMC) function in vitro. …”
Get full text
Get full text

αv Integrins combine with LC3 and atg5 to regulate Toll-like receptor signalling in B cells by Acharya, Mridu, Sokolovska, Anna, Tam, Jenny M., Conway, Kara L., Stefani, Caroline, Raso, Fiona, Mukhopadhyay, Subhankar, Feliu, Marianela, Paul, Elahna, Savill, John, Hynes, Richard O., Xavier, Ramnik J., Vyas, Jatin M., Stuart, Lynda M., Lacy-Hulbert, Adam, Hynes, Richard O.

“…Integrin signalling triggers cytoskeletal rearrangements, including endocytosis and exocytosis of integrins and other membrane proteins. …”
Get full text
Get full text

Integrin alpha 5 beta 1 is necessary for regulation of radial migration of cortical neurons during mouse brain development by Marchetti, Giovanni, Escuin, Sarah, van der Flier, Arjan, De Arcangelis, Adele, Georges-Labouesse, Elisabeth, Hynes, Richard O

“…Several integrin heterodimers are present during formation of the cortical layers. …”
Get full text
Get full text

Contact-dependent carcinoma aggregate dispersion by M2a macrophages via ICAM-1 and β2 integrin interactions by Dang, Truong-Minh, Tu, Ting-Yuan, Penny, Hwei-Xian Leong, Wong, Siew-Cheng, Thiery, Jean-Paul, Bai, Jing, Adriani, Giulia, Kamm, Roger Dale

“…A significant difference was observed when M2a macrophages were in direct contact with or separated from A549 aggregates, suggesting a possible mechanism for proximity-induced, contact-dependent dissemination via ICAM-1 and integrin β2 interactions. Indeed, M2a macrophages tended to infiltrate and release cells from carcinoma cell aggregates. …”
Get full text
Get full text

Contact-dependent carcinoma aggregate dispersion by M2a macrophages via ICAM-1 and β2 integrin interactions by Bai, Jing, Adriani, Giulia, Dang, Truong-Minh, Tu, Ting-Yuan, Penny, Hwei-Xian Leong, Wong, Siew-Cheng, Thiery, Jean-Paul, Kamm, Roger Dale

“…A significant difference was observed when M2a macrophages were in direct contact with or separated from A549 aggregates, suggesting a possible mechanism for proximity-induced, contact-dependent dissemination via ICAM-1 and integrin β2 interactions. Indeed, M2a macrophages tended to infiltrate and release cells from carcinoma cell aggregates. …”
Get full text
Get full text

[alpha]v and [beta]1 integrins regulate dynamic compression-induced proteoglycan synthesis in 3D gel culture by distinct complementary pathways by Grodzinsky, Alan J., Chai, Diana H., Griggs, D. W., Arner, E. C.

“…Objective Our goal was to test the hypothesis that specific integrin receptors regulate chondrocyte biosynthetic response to dynamic compression at early times in 3D gel culture, during initial evolution of the pericellular matrix, but prior to significant accumulation of further-removed matrix. …”
Get full text
Get full text

α[subscript v]β[subscript 3] Integrin-Targeted PLGA-PEG Nanoparticles for Enhanced Anti-tumor Efficacy of a Pt(IV) Prodrug by Graf, Nora, Bielenberg, Diane R., Kolishetti, Nagesh, Muus, Christoph, Banyard, Jacqueline, Farokhzad, Omid C., Lippard, Stephen J.

“…The α[subscript v]β[subscript 3] integrin is differentially upregulated on angiogenic endothelial cells as well as on many cancer cells. …”
Get full text
Get full text

Integrin-α5β1 is not required for mural cell functions during development of blood vessels but is required for lymphatic-blood vessel separation and lymphovenous valve formation by Turner, Christopher J., Badu-Nkansah, Kwabena, Crowley, Denise, van der Flier, Arjan, Hynes, Richard O.

“…Integrin α5β1 is essential for vascular development but it remains unclear precisely where and how it functions. …”
Get full text