Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma by Sabatini, David, Wolfson, Rachel Laura, Efeyan, Alejo

“…Follicular lymphoma is an incurable B cell malignancy characterized by the t(14;18) translocation and mutations affecting the epigenome. …”
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Discovery and Characterization of Super-Enhancer-Associated Dependencies in Diffuse Large B Cell Lymphoma by Chapuy, Bjoern, McKeown, Michael R., Lin, Charles Y., Monti, Stefano, Roemer, Margaretha G.M., Qi, Jun, Rahl, Peter B., Sun, Heather H., Yeda, Kelly T., Doench, John G., Reichert, Elaine, Kung, Andrew L., Rodig, Scott J., Young, Richard A., Shipp, Margaret A., Bradner, James E., Young, Richard A.

“…Diffuse large B cell lymphoma (DLBCL) is a biologically heterogeneous and clinically aggressive disease. …”
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In Vivo RNAi Screening Identifies Regulators of Actin Dynamics as Key Determinants of Lymphoma Progression by Ho, Emily E., Dubrovsky, Esther, Gertler, Frank, Meacham, Corbin Elizabeth, Hemann, Michael

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Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing by Lander, Eric Steven

“…To gain insight into the genomic basis of diffuse large B-cell lymphoma (DLBCL), we performed massively parallel whole-exome sequencing of 55 primary tumor samples from patients with DLBCL and matched normal tissue. …”
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Functional Identification of Tumor Suppressor Genes Through an in vivo RNA Interference Screen in a Mouse Lymphoma Model by Bric, Anka, Miething, Cornelius, Bialucha, Carl Uli, Scuoppo, Claudio, Zender, Lars, Krasnitz, Alexander, Xuan, Zhenyu, Zuber, Johannes, Wigler, Michael, Hicks, James, McCombie, Richard W., Hemann, Michael, Hannon, Gregory J., Powers, Scott, Lowe, Scott W.

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Rapid generation of human B-cell lymphomas via combined expression of Myc and Bcl2 and their use as a preclinical model for biological therapies by Schweighofer, C. D., Abruzzo, L., Frenzel, Lukas P., Wendtner, C. M., Leskov, Ilya B., Pallasch, Christian, Drake, Adam, Iliopoulou, Bettina P., Souza, A., Shen, C.-H., Hemann, Michael, Chen, Jianzhu

“…As a proof of principle, we used this model to show that the anti-CD52 antibody alemtuzumab effectively eliminates lymphoma cells from the spleen, liver and peripheral blood, but not from the brain. …”
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Genome-wide Association Study Identifies Shared Risk Loci Common to Two Malignancies in Golden Retrievers by Tonomura, Noriko, Elvers, Ingegerd, Thomas, Rachael, Megquier, Kate, Turner-Maier, Jason, Howald, Cedric, Sarver, Aaron L., Swofford, Ross, Frantz, Aric M., Ito, Daisuke, Mauceli, Evan, Arendt, Maja, Noh, Hyun Ji, Koltookian, Michele, Biagi, Tara, Fryc, Sarah, Williams, Christina, Avery, Anne C., Kim, Jong-Hyuk, Barber, Lisa, Burgess, Kristine, Karlsson, Elinor K., Azuma, Chieko, Modiano, Jaime F., Breen, Matthew, Lindblad-Toh, Kerstin, Lander, Eric Steven

“…Dogs, with their breed-determined limited genetic background, are great models of human disease including cancer. Canine B-cell lymphoma and hemangiosarcoma are both malignancies of the hematologic system that are clinically and histologically similar to human B-cell non-Hodgkin lymphoma and angiosarcoma, respectively. …”
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Active targeting of chemotherapy to disseminated tumors using nanoparticle-carrying T cells by Abraham, Wuhbet, Zheng, Yiran, Huang, Bonnie, Bustamante Lopez, Sandra C, Irvine, Darrell J, Luo, Samantha

“…In a murine model of disseminated lymphoma, we expanded autologous polyclonal T cells ex vivo under conditions that retained homing receptors mirroring lymphoma cells, and functionalized these T cells to carry SN-38–loaded nanocapsules on their surfaces. …”
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T-cell death following immune activation is mediated by mitochondria-localized SARM by Panneerselvam, P., Singh, L. P., Selvarajan, V., Chng, W. J., Ng, S. B., Tan, N. S., Ho, B., Ding, Jeak Ling, Chen, Jianzhu

“…Mechanistically, SARM mediates intrinsic apoptosis via B cell lymphoma-2 (Bcl-2) family members. SARM suppresses B cell lymphoma-extra large (Bcl-xL) and downregulates extracellular signal-regulated kinase phosphorylation, which are cell survival effectors. …”
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TET1 is a tumor suppressor of hematopoietic malignancy by Cimmino, Luisa, Ndiaye-Lobry, Delphine, Yap, Yoon Sing, Bakogianni, Sofia, Yu, Yiting, Bhattacharyya, Sanchari, Shaknovich, Rita, Geng, Huimin, Lobry, Camille, Mullenders, Jasper, King, Bryan, Trimarchi, Thomas, Aranda-Orgilles, Beatriz, Liu, Cynthia, Shen, Steven, Verma, Amit K, Aifantis, Iannis, Dawlaty, Meelad M, Jaenisch, Rudolf

“…Whole-exome sequencing of TET1-deficient tumors revealed mutations frequently found in non-Hodgkin B cell lymphoma (B-NHL), in which TET1 was hypermethylated and transcriptionally silenced. …”
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CDK-dependent phosphorylation and nuclear exclusion coordinately control kinetochore assembly state by Gascoigne, Karen E., Cheeseman, Iain M

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DNA Damage-Mediated Induction of a Chemoresistant Niche by Gilbert, Luke Andrew, Hemann, Michael

“…Here, we use a well-established mouse model of Burkitt's lymphoma to show that paracrine factors in the tumor microenvironment modulate lymphoma cell survival following the administration of genotoxic chemotherapy. …”
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Learning signaling network structures with sparsely distributed data by Sachs, Karen, Itani, Solomon, Carlisle, Jennifer, Nolan, Garry P., Pe'er, Dana, Lauffenburger, Douglas A.

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Multiclass Classification of SRBCTs by Yeo, Gene, Poggio, Tomaso

“…The method successfully classified and diagnosed small, round blue cell tumors (SRBCTs) of childhood into four distinct categories, neuroblastoma (NB), rhabdomyosarcoma (RMS), non-Hodgkin lymphoma (NHL) and the Ewing family of tumors (EWS), using cDNA gene expression profiles of samples that included both tumor biopsy material and cell lines. …”
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MicroRNA Functions in Stress Responses by Leung, Anthony, Sharp, Phillip A.

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Regulation of thymocyte positive selection and motility by GIT2 by Phee, Hyewon, Dzhagalov, Ivan, Mollenauer, Marianne, Wang, Yana, Irvine, Darrell J., Robey, Ellen, Weiss, Arthur

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Inferring transient particle transport dynamics in live cells by Park, Hye Yoon, Katz, Zachary, English, Brian P., Singer, Robert H., Monnier, Nilah, Barry, Zachary Thomas, Su, Kuan-Chung, Dey, Arkajit, Pan, Keyao, Cheeseman, Iain M, Bathe, Mark

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Polo-like Kinase 1 Licenses CENP-A Deposition at Centromeres by McKinley, Kara Lavidge, Cheeseman, Iain M

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Selecting Relevant Genes with a Spectral Approach by Wolf, Lior, Amnon Shashua, Mukherjee, Sayan

“…The other four datasets include three well studied treatment outcomes (large cell lymphoma, childhood medulloblastomas, breast tumors) and one unpublished dataset (lymph status). …”
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MicroRNAs: the primary cause or a determinant of progression in leukemia? by Bousquet, Marina, Lodish, Harvey F.

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