Pulsation and stabilization: Contractile forces that underlie morphogenesis by Martin, Adam C

“…Contractile forces generated by the actin–myosin cytoskeleton are critical for morphogenesis, but the cellular and molecular mechanisms of contraction have been elusive for many cell shape changes and movements. …”
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The Multiple Roles of Cohesin in Meiotic Chromosome Morphogenesis and Pairing by Brar, Gloria A., Ee, Ly-Sha, Hochwagen, Andreas, Amon, Angelika B

“…These findings define Rec8 as a key determinant of meiotic chromosome morphogenesis and a central player in multiple meiotic events.…”
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RhoA GTPase inhibition organizes contraction during epithelial morphogenesis by Mason, Frank M, Xie, Shicong, Vasquez, Claudia G, Martin, Adam C, Tworoger, Michael B.

“…During morphogenesis, contraction of the actomyosin cytoskeleton within individual cells drives cell shape changes that fold tissues. …”
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Ezrin regulates microvillus morphogenesis by promoting distinct activities of Eps8 proteins by Zwaenepoel, Ingrid, Da, Marcel Menezes Lyra, Maestro, Laurence Del, Formstecher, Etienne, Louvard, Daniel, Arpin, Monique, Naba, Alexandra

“…The mechanisms that regulate actin filament polymerization resulting in the morphogenesis of the brush border microvilli in epithelial cells remain unknown. …”
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Surface-Mediated Bone Tissue Morphogenesis from Tunable Nanolayered Implant Coatings by Shah, Nisarg J., Hyder, Md Nasim, Moskowitz, Joshua Seth, Quadir, Mohiuddin Abdul, Morton, Stephen Winford, Seeherman, Howard J., Padera, Robert F., Spector, Myron, Hammond, Paula T

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Volume conservation principle involved in cell lengthening and nucleus movement during tissue morphogenesis by Gelbart, Michael A., He, Bing, Thiberge, Stephan Y., Wieschaus, Eric F., Kaschube, Matthias, Martin, Adam C

“…Tissue morphogenesis is the process in which coordinated movements and shape changes of large numbers of cells form tissues, organs, and the internal body structure. …”
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Oxygen-Dependent Morphogenesis of Modern Clumped Photosynthetic Mats and Implications for the Archean Stromatolite Record by Sim, Min Sub, Liang, Biqing, Petroff, Alexander P., Evans, Alex J., Klepac-Ceraj, Vanja, Flannery, David T., Walter, Malcolm R., Bosak, Tanja

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Dynamic myosin phosphorylation regulates contractile pulses and tissue integrity during epithelial morphogenesis by Tworoger, Michael B., Vasquez, Claudia G, Martin, Adam C

“…It is not understood whether Myo-II phosphoregulation organizes contractile pulses or whether pulses are important for tissue morphogenesis. Here, we show that Myo-II pulses are associated with pulses of apical Rok. …”
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A DPP-mediated feed-forward loop canalizes morphogenesis during Drosophila dorsal closure by Keeley, Charlotte N., Ducuing, Antoine, Mollereau, Bertrand, Vincent, Stephane

“…We propose that the main function of DPP pathway during Drosophila DC is to ensure robust morphogenesis, a distinct function from its well-established ability to spread spatial information.…”
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Interstitial Fluid Flow Intensity Modulates Endothelial Sprouting in Restricted Src-Activated Cell Clusters During Capillary Morphogenesis by Lauffenburger, Douglas A., Kamm, Roger Dale, Genove, Elsa, Borros, Salvador, Semino, Carlos Eduardo, Hernandez Vera, Rodrigo, Alvarez, Lery

“…Therefore, we have studied capillary morphogenesis under controlled biological and biophysical conditions with the aim of promoting vascular structures in tissue constructs. …”
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Epithelial Relaxation Mediated by the Myosin Phosphatase Regulator Mypt1 Is Required for Brain Ventricle Lumen Expansion and Hindbrain Morphogenesis by Gutzman, Jennifer H., Sive, Hazel L.

“…We demonstrate that in the zebrafish hindbrain, cell shape, rhombomere morphogenesis and, unexpectedly, brain ventricle lumen expansion depend on the contractile state of the neuroepithelium. …”
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Human embryonic stem cell-derived keratinocytes exhibit an epidermal transcription program and undergo epithelial morphogenesis in engineered tissue constructs by Metallo, Christian M., Azarin, Samira M., Moses, Laurel E., Ji, Lin, Pablo, Juan J. de, Palecek, Sean P.

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Dynamic patterns of brain cell assemblies : a report based on an NRP work session held May 14-16, 1972, and updated by participants : Aharon Katzir Katchalsky and Vernon Rowland, c...

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Trans-membrane Signal Transduction and Biochemical Turing Pattern Formation by Millonas, Mark M., Rauch, Erik M.

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Fast Microtubule Dynamics in Meiotic Spindles Measured by Single Imaging: Evidence that the Spindle Environment does not Stabilize Microtubules by Mirny, Leonid A., Mitchison, Timothy J., Maresca, Tom, Ohi, Ryoma, Groen, Aaron, Needleman, Daniel J.

“…Since the discovery of dynamic instability in the mid-1980s, models for spindle morphogenesis have proposed that microtubules are stabilized by the spindle environment. …”
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Integration of contractile forces during tissue invagination by Martin, Adam C., Gelbart, Michael A., Fernandez-Gonzalez, Rodrigo, Kaschube, Matthias, Wieschaus, Eric F.

“…Thus, pulsed actomyosin contractions require a supracellular, tensile meshwork to transmit cellular forces to the tissue level during morphogenesis.…”
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Dissecting spatio-temporal protein networks driving human heart development and related disorders by Lage, Kasper, Møllgård, Kjeld, Greenway, Steven, Wakimoto, Hiroko, Gorham, Joshua M., Workman, Christopher T., Bendsen, Eske, Hansen, Niclas T., Rigina, Olga, Roque, Francisco S., Wiese, Cornelia, Christoffels, Vincent M., Roberts, Amy E., Smoot, Leslie B., Pu, William T., Donahoe, Patricia, Tommerup, Niels, Brunak, Søren, Seidman, Christine E., Seidman, Jonathan G., Larsen, Lars A.

“…Aberrant organ development is associated with a wide spectrum of disorders, from schizophrenia to congenital heart disease, but systems-level insight into the underlying processes is very limited. Using heart morphogenesis as general model for dissecting the functional architecture of organ development, we combined detailed phenotype information from deleterious mutations in 255 genes with high-confidence experimental interactome data, and coupled the results to thorough experimental validation. …”
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Perturbation-Expression Analysis Identifies RUNX1 as a Regulator of Human Mammary Stem Cell Differentiation by Sanduja, Sandhya, Jin, Dexter X., Sokol, Ethan Samuel, Miller, Daniel Handel, Mathis, Robert Austin, Gupta, Piyush

“…We have applied this marker-free approach to screen for transcription factors that regulate mammary stem cell differentiation in a 3D model of tissue morphogenesis and identified RUNX1 as a stem cell regulator. …”
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Actin cytoskeleton: Thinking globally, actin’ locally by Lanier, Lorene M., Gertler, Frank

“…Local release of PIP2 controls actin dynamics in specific subcellular regions and plays a critical role in regulating actin-based cell motility and morphogenesis.…”
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Partial Redundancy and Morphological Homeostasis: Reliable Development through Overlapping Mechanisms by Brodsky, Micah Zev

“…This article presents a case study in simulated morphogenesis, using a physics-based model for embryonic epithelial tissue. …”
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