Integrated genomic analyses of ovarian carcinoma by Meyerson, Matthew L., Lander, Eric Steven

“…A catalogue of molecular aberrations that cause ovarian cancer is critical for developing and deploying therapies that will improve patients’ lives. …”
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Cisplatin Resistant Spheroids Model Clinically Relevant Survival Mechanisms in Ovarian Tumors by Chowanadisai, Winyoo, Messerli, Shanta M., Miller, Daniel Handel, Medina, Jamie E., Hamilton, Joshua W., Messerli, Mark A., Brodsky, Alexander S.

“…The majority of ovarian tumors eventually recur in a drug resistant form. …”
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UNRAVELING THE ORIGIN OF OVERIONIZED PLASMA IN THE GALACTIC SUPERNOVA REMNANT W49B by Lopez, Laura A., Pearson, Sarah, Ramirez-Ruiz, Enrico, Castro, Daniel, Yamaguchi, Hiroya, Slane, Patrick O., Smith, Randall K.

“…Using these results, we find that W49B is overionized in the west, with a gradient of overionization increasing from east to west. …”
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Sustained, low-dose intraperitoneal cisplatin improves treatment outcome in ovarian cancer mouse models by Na, Young Jeong, Fulci, Giulia, del Carmen, Marcela G., Birrer, Michael J., Ye, Hongye, Tanenbaum, Laura Melanie, Mantzavinou, Aikaterini, Cima, Michael J.

“…Intraperitoneal (IP) chemotherapy for ovarian cancer treatment prolongs overall survival by 16 months compared to intravenous chemotherapy but is not widely practiced due to catheter-related complications and complexity of administration. …”
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Targeted Tumor-Penetrating siRNA Nanocomplexes for Credentialing the Ovarian Cancer Target ID4 by Ren, Yin, von Maltzhan, Geoffrey, Agrawal, Amit, Mesirov, Jill P., Lo, Justin H., Cheung, Hiu Wing, Cowley, Glenn S., Weir, Barbara A., Boehm, Jesse S., Tamayo, Pablo, Karst, Alison M., Liu, Joyce F., Hirsch, Michelle S., Drapkin, Ronny, Root, David E., Fogal, Valentina, Ruoslahti, Erkki, Hahn, William C., Bhatia, Sangeeta N

“…We used TPN in vivo to evaluate inhibitor of DNA binding 4 (ID4) as a novel oncogene. Treatment of ovarian tumor–bearing mice with ID4-specific TPN suppressed growth of established tumors and significantly improved survival. …”
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The Ligand Binding Domain of GCNF Is Not Required for Repression of Pluripotency Genes in Mouse Fetal Ovarian Germ Cells by Okumura, Leah M., Lesch, Bluma J., Page, David C.

“…Here we demonstrate that Gcnf is expressed in fetal ovarian germ cells, peaking at E14.5, when Oct4 and Nanog are silenced. …”
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Layer-by-layer assembled fluorescent probes in the second near-infrared window for systemic delivery and detection of ovarian cancer by Dang, Xiangnan, Gu, Li, Qi, Jifa, Correa Echavarria, Santiago, Zhang, Geran, Belcher, Angela M, Hammond, Paula T

“…Successful detection of orthotopic ovarian tumors is achieved by in vivo NIR-II imaging and confirmed by ex vivo microscopic imaging. …”
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Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer by Ren, Yin, Meyerson, Matthew L., Drapkin, Ronny, Cheung, Hiu Wing, Cowley, Glenn S., Weir, Barbara A., Boehm, Jesse S., Rusin, Scott, Scott, Justine A., East, Alexandra, Ali, Levi D., Lizotte, Patrick H., Wong, Terence C., Jiang, Guozhi, Hsiao, Jessica, Mermel, Craig H., Getz, Gad, Barretina, Jordi, Gopal, Shuba, Tamayo, Pablo, Gould, Joshua, Tsherniak, Aviad, Stransky, Nicolas, Luo, Biao, Mesirov, Jill P., Garraway, Levi A., Lander, Eric S., Root, David E., Hahn, William C., Bhatia, Sangeeta N

“…One such gene, PAX8, is focally amplified in 16% of high-grade serous ovarian cancers and expressed at higher levels in ovarian tumors. …”
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Flow induces epithelial-mesenchymal transition, cellular heterogeneity and biomarker modulation in 3D ovarian cancer nodules by Demirci, Utkan, Hasan, Tayyaba, Rizvi, Imran, Gurkan, Umut Atakan, Tasoglu, Savas, Alagic, Nermina, Celli, Jonathan P., Mensah, Lawrence B., Mai, Zhiming

“…Seventy-five percent of patients with epithelial ovarian cancer present with advanced-stage disease that is extensively disseminated intraperitoneally and prognosticates the poorest outcomes. …”
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A Pt(IV) Pro-drug Preferentially Targets Indoleamine-2,3-dioxygenase, Providing Enhanced Ovarian Cancer Immuno-Chemotherapy by Awuah, Samuel, Zheng, Yaorong, Bruno, Peter Michael, Hemann, Michael, Lippard, Stephen J.

“…Compound 2 effectively kills hormone-dependent, cisplatin-resistant human ovarian cancer cells, inhibiting IDO by transcriptional deregulation of the auto-crine-signaling loop IDO-AHR-IL6, which blocks kynurenine production and promotes T-cell proliferation. …”
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A 3D model of ovarian cancer cell lines on peptide nanofiber scaffold to explore the cell–scaffold interaction and chemotherapeutic resistance of anticancer drugs by Yang, Zehong, Zhao, Xiaojun

“…The cancer cell–nanofiber scaffold construct was cultured for 5 days, and the ovarian cancer cells had actively proliferative potential. …”
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Nanoparticle-mediated delivery of siRNA targeting Parp1 extends survival bearing tumors derived from Brca1-deficient ovarian cancer cells by Goldberg, Michael Solomon, Xing, Deyin, Ren, Yin, Orsulic, Sandra, Sharp, Phillip A., Bhatia, Sangeeta N

“…Inhibition of the DNA repair enzyme poly(ADP-ribose) polymerase 1 (PARP1) with small molecules has been shown to be an effective treatment for ovarian cancer with BRCA mutations. Here, we report the in vivo administration of siRNA to Parp1 in mouse models of ovarian cancer. …”
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The water's edge: critical problems of the Coastal Zone.

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Naval Engineering A National Naval Obligation by Chryssostomidis, Chryssostomos, Bernitsas, Michael, Burke, David

Subjects: “…Naval Architecture and Marine Engineering…”
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SPECTRAL STATE DEPENDENCE OF THE 0.4–2 MEV POLARIZED EMISSION IN CYGNUS X-1 SEEN WITH INTEGRAL/IBIS, AND LINKS WITH THE AMI RADIO DATA by Laurent, Philippe, Bel, Marion Cadolle, Pottschmidt, Katja, Pooley, Guy, Bodaghee, Arash, Rodriguez, Jerome, Grinberg, Victoria, Wilms, Jorn, Gouiffes, Christian

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Differential effects of cocaine on histone posttranslational modifications in identified populations of striatal neurons by Heiman, Myriam, Jordi, Emmanuelle, Marion-Poll, Lucile, Guermonprez, Pierre, Cheng, Shuk Kei, Nairn, Angus C., Greengard, Paul, Girault, Jean-Antoine

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Public policy for the seas

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Optimization-based locomotion planning, estimation, and control design for the atlas humanoid robot by Koolen, Twan, Marion, Pat, Kuindersma, Scott, Deits, Robin Lloyd Henderson, Fallon, Maurice, Valenzuela, Andres Klee, Dai, Hongkai, Permenter, Frank Noble, Tedrake, Russell L

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Molecular signatures of neural connectivity in the olfactory cortex by Diodato, Assunta, Ruinart de Brimont, Marion, Derian, Nicolas, Perrin, Sandrine, Pouch, Juliette, Klatzmann, David, Garel, Sonia, Fleischmann, Alexander, Yim, Yeong Shin, Choi, Bohyun Gloria

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MULTI-COLOR OPTICAL AND NEAR-INFRARED LIGHT CURVES OF 64 STRIPPED-ENVELOPE CORE-COLLAPSE SUPERNOVAE by Bianco, F. B., Modjaz, Maryam, Hicken, M., Friedman, Andrew Samuel, Bloom, Joshua S. Kirshner, Robert P., Bloom, Joshua S., Challis, Peter, Marion, G. Howie, Wood-Vasey, W. M., Rest, A.

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