Control of adipogenesis by the autocrine interplays between angiotensin 1–7/mas receptor and angiotensin II/AT1 receptor signaling pathways by Than, Aung, Leow, Melvin Khee-Shing, Chen, Peng

“…The autocrine regulation of the AngII/AT1-ACE2-Ang(1-7)/Mas axis upon adipogenesis has also been revealed. …”
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3D spheroid-microvasculature-on-a-chip for tumor-endothelium mechanobiology interplay by Zhang, Yingqi, Jiang, Fengtao, Zhao, Charles Yunduo, Cho, Ann-Na, Fang, Guocheng, Cox, Charles D., Zreiqat, Hala, Lu, Zu Fu, Lu, Hongxu, Ju, Arnold Lining

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Student teachers learning to use Assessment for Learning in schools by Tan Chia Chun, D

Remote digital cognitive assessment reveals cognitive deficits related to hippocampal atrophy in autoimmune limbic encephalitis: a cross-sectional validation study by Shibata, K, Attaallah, B, Tai, X-Y, Trender, W, Hellyer, PJ, Hampshire, A, Irani, SR, Manohar, SG, Husain, M

“…The global score on the online cognitive tasks correlated significantly with the established Addenbrooke’s Cognitive Examination III (ACE) pen-and-paper test. Deficits in visuospatial processing and language were identified in ALE compared to controls using remote digital testing but not using the ACE, highlighting higher sensitivity of computerised testing to residual cognitive impairment. …”

Covid-19 antibody discovery with topology-enhanced learning models by Wang, Zihong

“…The impact of variants on infectivity and monoclonal antibodies (mAbs) effectiveness is largely determined by how related receptor-binding domain (RBD) mutations affect ACE2 and antibody binding. Topological Data Analysis (TDA) is a fast-growing field combining topology and computational geometry to retrieve features from high-dimensional datasets. …”
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Rapid and Scalable Production of Functional SARS-CoV-2 Virus-like Particles (VLPs) by a Stable HEK293 Cell Pool by Puarattana-aroonkorn, Sitthiphol, Tharakaraman, Kannan, Suriyawipada, Disapan, Ruchirawat, Mathuros, Fuangthong, Mayuree, Sasisekharan, Ram, Artpradit, Charlermchai

“…Our particles were functional as they specifically entered the cell that naturally expresses ACE-2. Notably, this work reports a practical and cost-effective manufacturing platform for scalable SARS-CoV-2 VLPs production and chromatographic purification.…”
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Finding transcription factor binding motifs for coregulated genes by combining sequence overrepresentation with cross-species conservation by Jia, Hui., Li, Jinming.

“…We applied the method to 35 S. cerevisiae transcriptional factors with known DNA binding motifs (with the support of orthologous sequences from genomes of S. mikatae, S. bayanus, and S. paradoxus), and the proposed method outperformed the single-genome-based motif finding methods MEME and AlignACE as well as the multiple-genome-based methods PHYME and Footprinter for the majority of these transcriptional factors. …”
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SARS-CoV-2 evolution during treatment of chronic infection by Kemp, SA, Collier, DA, Datir, RP, Ferreira, IATM, Gayed, S, Jahun, A, Hosmillo, M, Rees-Spear, C, Mlcochova, P, Lumb, IU, Roberts, DJ, Chandra, A, Temperton, N, Sharrocks, K, Blane, E, Modis, Y, Leigh, KE, Briggs, JAG, van Gils, MJ, Smith, KGC, Bradley, JR, Smith, C, Doffinger, R, Ceron-Gutierrez, L, Barcenas-Morales, G, Pollock, DD, Goldstein, RA, Smielewska, A, Skittrall, JP, Gouliouris, T, Goodfellow, IG, Gkrania-Klotsas, E, Illingworth, CJR, McCoy, LE, Gupta, RK

“…The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical for virus infection through the engagement of the human ACE2 protein1 and is a major antibody target. Here we show that chronic infection with SARS-CoV-2 leads to viral evolution and reduced sensitivity to neutralizing antibodies in an immunosuppressed individual treated with convalescent plasma, by generating whole-genome ultra-deep sequences for 23 time points that span 101 days and using in vitro techniques to characterize the mutations revealed by sequencing. …”

Immunoprofiling of drug-resistant epilepsy with a focus on glutamic acid decarboxylase 65 antibodies by McGinty, R

“…Neuronal surface-directed autoantibody (NSA) status was best predicted by older age, ictal piloerection, epilepsy risk factors, mood problems, attention domain of the Addenbrooke's Cognitive Examination-Revised (ACE-R) and limbic system changes on MRI.</p> <p>A fixed and permeabilised CBA was developed to detect GAD65 IgG autoantibodies in serum, plasma, CSF and supernatants of cultured peripheral blood mononuclear cells (PBMCs). …”

Generation of self-replicating airway organoids from the cave nectar bat Eonycteris spelaea as a model system for studying host-pathogen interactions in the bat airway epithelium by Chan, Louisa L. Y., Gamage, Akshamal M., Tan, Chee Wah, Tan, Kai Sen, Liu, Jing, Tay, Douglas Jie Wen, Foo, Randy Jee Hiang, Rénia, Laurent, Wang, De Yun, Wang, Lin-Fa

“…However, these ALI-AECs did not support SARS-CoV-2 infection, despite E. spelaea ACE2 receptor being capable of mediating SARS-CoV-2 spike pseudovirus entry. …”
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Relative deficiency in interferon-γ-secreting CD4+ T cells is strongly associated with poorer COVID-19 vaccination responses in older adults by Ho, Vanda W. T., Boon, Low Heng, Cui, Jianzhou, Juequn, Zhou, Shunmuganathan, Bhuvaneshwari, Gupta, Rashi, Tan, Nikki Y. J., Qian, Xinlei, Purushotorman, Kiren, Fong, Siew-Wai, Renia, Laurent, Ng, Lisa F. P., Angeli, Veronique, Chen, Jinmiao, Kennedy, Brian K., Ong, Catherine W. M., Macary, Paul A.

“…We assessed functional, neutralising antibody responses against SARS-CoV-2 variants using ACE-2 inhibition assays, and changes in B and T-cell subsets by high-dimensional flow cytometry. …”
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Yeast9: a consensus genome-scale metabolic model for S. cerevisiae curated by the community by Zhang, Chengyu, Sánchez, Benjamín J., Li, Feiran, Cheng, Eiden Wei Quan, Scott, William T., Liebal, Ulf W., Blank, Lars M., Mengers, Hendrik G., Anton, Mihail, Rangel, Albert Tafur, Mendoza, Sebastián N., Zhang, Lixin, Nielsen, Jens, Lu, Hongzhong, Kerkhoven, Eduard J.

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The association between adverse childhood experiences and adult cardiac function in the UK Biobank by Quiroz, JC, Cooper, J, McCracken, C, Khanji, MY, Laranjo, L, Aung, N, Lee, AM, Simon, J, Murphy, T, Biasiolli, L, Piechnik, SK, Maurovich-Horvat, P, Petersen, SE, Raisi-Estabragh, Z

“…These findings suggest that dedicated efforts are needed to communicate the impact of ACEs on cardiovascular health to parents, patients, and clinicians and incorporate the discussion of ACEs when assessing cardiovascular risk.…”

Should competition monopolise merger policy? by Vickers, J

“…ACE Keynote Lecture, Milan, 16 November 2024.…”

Establishing the association between traditional tobacco, e-cigarette and dual use and mental health problems among high school students: results from a 2022 behavioral surveillanc... by Thepthien, BO, Tinn, CS, Sharma, R

“…The use of a substance (e.g., cannabis, alcohol), having mental health problems (e.g., having PD, PG, sleep disturbance, &gt; 4 ACEs) and having friends or family members who use cigarettes were highly associated with use of CC, EC and dual use. …”

Topological phase transition in quasi-one-dimensional bismuth iodide Bi 4 I 4 by Zhao, WX, Yang, M, Du, X, Li, YD, Zhai, KY, Hu, YQ, Han, JF, Huang, Y, Liu, ZK, Yao, YG, Zhuang, JC, Du, Y, Zhou, JJ, Chen, YL, Yang, LX

CET-4 Cloze passage personalized learning by Thoo, Emilene Shu Ping

“…There are many sections in the CET and the main focus of this project is to develop a web application to assist undergraduates and postgraduates in acing the cloze passages section by providing a user profile for personalized learning.…”
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Fiona Patrick - Thesis submitted in partial fulfilment of the degree of Doctor of Clinical Psychology (DClinPsych) by Patrick, F

“…No predictive relationship between ACEs or NSB and BMI was identified, nor any mediating effect of NSB or moderating effect of self-compassion on these relationships. …”