Regulation of coronavirus gene expression by the 5'-untranslated region. by Guo, Huiling.

“…Furthermore, it was found that a disruption of SL1 could result in a slight decrease in gene expression. Hence, these suggest that nts 363 to 528 in the 5’-UTR might be important in enhancing gene expression while SL1 could contribute itself as an initiator for gene expression in IBV.…”
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Application of feature selection algorithms in gene expression data analysis by Wang, Ruiping.

“…Although there are several causes of cancer, scientists have made a major breakthrough in discovering a number of candidate genes that associated with certain cancers. These genes, recognized as biomarkers, can contribute in early cancer diagnosis and prognosis and hence raise the possibility of curative surgery. …”
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PubMed text data mining automation for biological validation on lists of genes and pathways by Nies, Hui Wen, Zakaria, Zalmiyah, Chan, Weng Howe, Kamsani, Izyan Izzati, Hasan, Nor Shahida

“…A list of genes and pathways from breast cancer are used in this study. …”
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Plasmid-Borne Biosynthetic Gene Clusters within a Permanently Stratified Marine Water Column by Mara, Paraskevi, Geller-McGrath, David, Suter, Elizabeth, Taylor, Gordon T., Pachiadaki, Maria G., Edgcomb, Virginia P.

“…These identified genes encode for secondary metabolites that are mainly antimicrobial agents, and hence, their uptake via plasmids may increase the competitive advantage of those host taxa that acquire them. …”
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Inhibitory Potential of the Truncated Isoforms on Glutamate Transporter Oligomerization Identified by Computational Analysis of Gene-Centric Isoform Maps by Karagöl, Alper, Karagöl, Taner, Li, Mengke, Zhang, Shuguang

“…Biological assemblies of the transporters, consisting of cyclic homotrimers, emerge as a crucial aspect of glutamate transporter modulation. Hence targeting heteromerization promises an effective approach for modulator design. …”
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Do the ‘big four’ orders of insects comprise evolutionarily significant higher taxa with coherent patterns of selection on protein-coding genes? by Février, PJ, Barraclough, T

“…Specifically, we ask whether the big four orders of holometabolous insects, namely Coleoptera, Diptera, Hymenoptera and Lepidoptera, display divergent, but internally conserved patterns of selection acting on protein-coding genes. Analysing orthologous genes from whole genome sequence data for multiple species per order, we find that, in most genes, selection on roughly one fifth of codons is conserved within each order but differs significantly among orders. …”

Part I : Peptide functionalized materials for gram-negative bacteria targeted PDT and LPS sensing. Part II : Small peptide and membrane lipid based self-assembled nanostructures fo... by Liu, Fang

“…The subsequent study using such clickable MVs as controlled drug/gene delivery vehicles is still in progress.…”
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Elucidating the genomic and transcriptomic profiles contributing to the overall survival of acute myeloid leukaemia patients with normal karyotype in Malaysia by Ambayya @ Ampiah, A Angeli

“…There were 27 types of fusion genes (n=68) discovered in this study, of which several novel recurrent fusion genes, including LATS2-SAP18 and HOXA3-HOXA9, exhibited prognostic relevance in patients with OS below five years. …”
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Nuclei sorting-based genome-wide CRISPR screens to identify novel regulators of hepatic insulin signalling by Martin Perez, E

“…</p> <p>This project is focused on identifying genes involved in hepatic insulin action and aims at a more detailed molecular understanding of how defects in the signalling pathway may lead to insulin resistance. …”

Effects of nnav1.5 expression modulation on mhc I antigen processing machinery and invasion potential of breast cancer cells by Din, Ahmad Hafiz Murtadha Noor

“…In summary, modulating nNav1.5 gene expression affected MHC I APM, CD274, and cell behaviour, hence can potentially improve breast cancer immunotherapies by countering tumour immune escape mechanism via rescuing MHC I. …”
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Journey into genetics: taking the twists and turns of life by Rosli, Rozita

“…Hence, the knowledge generated through human genetics research has the potential to improve individual and community health. …”
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Computational analysis for infectious diseases surveillance and host-pathogen interactions (in the context of Influenza A viruses) by Beyene, Biruhalem Taye

“…However, these studies were not consistent (reproducible) mainly due to false negative results. Hence, in the fourth project (chapter 6), we applied computational gene network growing for discovering gene network links that could have been missed by these experimental investigations. …”
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Investigating the role of factor inhibiting HIF (FIH) in tumourigenesis by Ma, J

“…HIF has been shown to exert broad, and sometimes controversial, effects on tumour progression through the induction of over 70 effector genes. Factor Inhibiting HIF (FIH), an oxygen-dependent hydroxylase of HIF, inhibits the transcription of selective HIF target genes, and is hence a potential therapeutic target to fine-tune HIF activity. …”

A hybrid of ant colony optimization, genetic algorithm and flux balance analysis for optimization of succinic acid production in Escherichia coli by Tan, Jun Bin, Choon, Yee Wen, Moorthy, Kohbalan, Hasyiya Karimah, Adli, Muhammad Akmal, Remli, Mohd Arfian, Ismail, Zuwairie, Ibrahim, Mohd Saberi, Mohamad

“…ACOGAFBA produced three sets of gene knockout lists. The dataset iiJR904 is used in this paper. …”
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PTEN-opathies : from biological insights to evidence-based precision medicine by Yehia, Lamis, Ngeow, Joanne, Eng, Charis

“…Hence, the PTEN-opathies serve as a prototype for bedside to bench, and back to the bedside, practice of evidence-based precision medicine.…”
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Analyzing the roles of human U1 snRNA variants in pre-mRNA processing. by Goh, Eling.

“…Interestingly, nine of these U1 variants have different 5’ends as compared to the major U1. Hence, we hypothesized that a subset of 5’ss in the human genome could be recognized by these U1 variants. …”
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Characterization of Newcastle disease virus (NDV) isolated from NDV vaccinated broiler farms and investigation of vaccine efficacy against challenge with Velogenic genotype VII NDV by Shahrestani, Kiarash Roohani

“…Hence, molecular characterization based on the F and HN genes indicated the viruses (IBS001 to IBS005) belong to velogenic genotype VII NDV. …”
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Development of a recombinant non-replicating Newcastle disease virus by Cheow, Pheik-Sheen, Tan, Tiong Kit, Song, Adelene Ai-Lian, Yusoff, Khatijah, Chia, Suet Lin

“…In this study, we aimed to produce a rNDV with a truncated ant-igenome via reverse genetics to render it non-replicating (nr). The genes responsible for replication were removed from the NDV genome. …”

Neuroprotective effect of tocotrienol-rich fraction and a-tocopherol of vitamin E against glutamate toxicity in neuronal cells and astrocytes by Selvaraju, Thilaga Rati

“…Human apoptosis quantitative PCR array analysis determined that post-treatment with 200 ng/mL TRF and α-TCP upregulated the anti-apoptotic genes and downregulated the pro-apoptotic genes in both the neuronal and astrocyte cell lines. …”
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Dna markers and mapping of quantitative trait loci for yield and bunch quality in Deli dura X Yangambi pisifera oil palm (Elaeis guineensis) population by Seng, Tzer Ying

“…The many QTLs detected per trait suggested that the traits studied are polygenic with many genes of individual small effects on independent loci. …”
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