Prediction of neutralising antibodies for novel coronavirus with machine learning by Kho, Jordon Junyang

“…However, the models were poor at correctly classifying the non-neutralising sequences and had false positive rates as high as 41%. Therefore, the exploration of other oversampling techniques in combination with undersampling techniques and the experimentation of different pooling approaches to capture atomic information more accurately could serve as new directions in future work.…”
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Rational design and synthesis of degradable poly(imidazolium ester) antibiotics by Xu, Xiaofei

“…Through systematic experimentation, we established a library of degradable antimicrobial polymers possessing antibiotic-like potency and tunable degradation rates. Systematic evaluation, assessing bacterial potency and toxicity, unveiled a standout candidate, PBIE3. …”
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Development and design optimisation of digital intensity measurement system for shot peening by Tarani, Dinesh Kumar

“…The force sensor readings are recorded at different air pressures and mass flow rates, the two primary parameters that affect peening intensity. …”
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Study of marine power train system through mathematical modelling of various electro-mechanical components by Khor, Boon Siang

“…The power generation system consists of five diesel engine generator sets with different rated power. They are modeled by using simplified first order transfer function for ease of simulation and system level analysis. …”
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Fluid velocity slip and temperature jump at a solid surface by Teo, Melvin Ji Bin

“…The net velocity and temperature of the near-wall molecules, equivalent to the slip velocity and temperature jump, can be evaluated by considering the relative rates of adsorption. Our first theoretical model focuses on the subject of fluid slip over solid surfaces, where the corresponding velocities of various adsorbed fluid molecules are analysed based on the dynamics of the adsorption processes. …”
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Heat transfer of 3D-printed porous structure used in cold plate by Tew, Hong Boon

“…The results suggest that with the same LD to LL ratio, the porous-filled cold plate of 64.8% has consistently better thermal performances as compared to the other cold plates for the range of flow rates tested. In addition, the results also show that at the highest ReD, the best-performing cold plate has approximately 6 times higher Nu as compared to that of the bare cold plate. …”
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Conformational ensemble modeling of multi-domain proteins with experimental data by Zhu, Guanhua

“…This ensemble is in good agreement with experimental PRE rates and also supported by the experimental data of chemical shift perturbations.…”
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Impact of the ballast water management convention on the maritime industry (technical impact) by Yeo, Kai Teng

“…In lieu of the negative repercussions, this paper has also included recommendations such as setting up a structured testing system and a rating system for all the type-approved BWTS. Such recommendations seek to enhance the robustness of the type-approved BWTS and thereby, further the effectiveness of the BWM Convention.…”
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Interannual coral Δ14C records of surface water exchange across the Luzon Strait by Ramos, R. D., Goodkin, N. F., Druffel, E. R. M., Fan, T. Y., Siringan, F. P.

“…While numericalmodels have investigated the interannual variability of the transport and subsequent water exchange acrossthe LS, a lack of long‐term on‐site records prevents a general consensus on the transport rates, variability,and drivers. Corals offer high‐resolution, continuous histories of radiocarbon (Δ14C) content of the seawaterdissolved inorganic carbon, allowing us to track changes in ocean transport and circulation through time.Seasonal and annualΔ14C samples from Houbihu, Taiwan, and Palaui, Philippines, located on either side ofthe strait, are compared to the Western Pacific Ocean and SCSΔ14C records to examine the spatial andtemporalΔ14C variability in the region. …”
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Theoretical study of spermatozoa sorting by dielectrophoresis or magnetophoresis with supervised learning by Koh, James Boon Yong

“…This sorting has potential to improve the probability of success for intrauterine insemination, given that pregnancy rates are similar as long as the percentage of normal cells exceed a minimum threshold, even if the initial motile sperm count is under a million. …”
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How one might miss early warning signals of critical transitions in time series data: A systematic study of two major currency pairs by Wen, Haoyu, Cheong, Siew Ann, Pica Ciamarra, Massimo

“…In this paper, we investigated why this might be so, by testing three commonly used indicators: lag-1 autocorrelation, variance, and low-frequency power spectrum at anticipating critical transitions in the very-high-frequency time series data of the Australian Dollar-Japanese Yen and Swiss Franc-Japanese Yen exchange rates. Besides testing rising trends in these indicators at a strict level of confidence using the Kendall-tau test, we also required statistically significant early warning signals to be concurrent in the three indicators, which must rise to appreciable values. …”
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Green development performance of water resources and its economic-related determinants by Li, Wei, Xi, Yongqin, Wu, Feimei, Masoud, Mahmoud, Liu, Shi Qiang

“…The main findings of this study are as follows: i) the level of water utilization is a critical factor for the government to decide whether to increase the GTFPWR via foreign direct investment and trade; ii) the amount of wastewater should be effectively reduced to mitigate the conflicts between urbanization and the GTFPWR growth; iii) inland provinces, particularly Shanxi, Hainan and Yunnan, need to improve water technologies and management to increase their low-GTFPWR-growth rates. Our analytical framework is practical to evaluate water-use productivity and its determinants, while our empirical findings provide new insights into the green development of water resources and may shed light on future policies of environmental management.…”
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An update of a systematic review and meta-analyses exploring flavours in intervention studies of e-cigarettes for smoking cessation by Lindson, N, Livingstone-Banks, J, Butler, A, Levy, D, Barnett, P, Theodoulou, A, Notley, C, Rigotti, N, Chen, Y, Hartmann-Boyce, J

“…One included study randomised participants to two different flavour conditions and found similar cessation rates and long-term e-cigarette use between arms at 12 months. …”

Development of CRISPR gene therapy for retinal degenerations by Fry, LE

“…I demonstrated in vitro that forward orientation of the gRNA improved expression and editing rates relative to reverse orientated gRNAs. Secondly, CasX—a novel, engineered, minimal Cas nuclease—was delivered within an all-in-one AAV vector via subretinal injection. …”

Effect of intra-articular corticosteroid injections for osteoarthritis on the subsequent use of pain medications: a UK CPRD cohort study by Hawley, S, Prats Uribe, A, Matharu, GS, Delmestri, A, Prieto Alhambra, D, Judge, A, Whitehouse, MR

“…Secondary analyses confirmed lower incidence rates of opioid-nonopioid combinations after single IACI for knee (hazard ratio [HR] =0.88 [0.81-0.96]), hip (HR=0.76 [0.62-0.92]), hand (HR=0.77 [0.61-0.98]), or shoulder (HR=0.70 [0.51-0.97]) osteoarthritis.…”

Combining detection dogs and camera traps improves minimally-invasive population monitoring for the cheetah, an elusive and rare large carnivore by Verschueren, S, Hofmann, T, Schmidt-Küntzel, A, Kakove, M, Munyandi, B, Bauer, H, Balkenhol, N, Leirs, H, Neumann, S, Cristescu, B, Marker, L

“…Some carnivores such as the cheetah (Acinonyx jubatus) are particularly wide-ranging and often go undetected despite being present, or are detected at rates too low to make meaningful quantitative inferences. …”

Translation of PET radiotracers for cancer imaging: recommendations from the National Cancer Imaging Translational Accelerator (NCITA) consensus meeting by McAteer, MA, McGowan, DR, Cook, GJR, Leung, HY, Ng, T, O’Connor, JPB, Aloj, L, Barnes, A, Blower, PJ, Brindle, KM, Braun, J, Buckley, C, Darian, D, Evans, P, Goh, V, Grainger, D, Green, C, Hall, MG, Harding, TA, Hines, CDG, Hollingsworth, SJ, Cristinacce, PLH, Illing, RO, Lee, M, Patel, N, Higgins, GS

“…Panellists independently completed a consensus survey of 57 questions, rating each on a 9-point Likert scale. Subsequently, panellists attended a consensus meeting to discuss survey outcomes and readjust scores independently if desired. …”

Clinical value of cell-based assays in the characterisation of seronegative myasthenia gravis by Damato, V, Spagni, G, Monte, G, Woodhall, M, Jacobson, L, Falso, S, Smith, T, Iorio, R, Waters, P, Irani, SR, Vincent, A, Evoli, A

“…Live cell-based assays (l-CBAs) can detect additional antibodies to clustered AChR, MuSK and low-density lipoprotein receptor-related protein 4 (LRP4), but positivity rates are variable and both clinical relevance and utility of CBA platforms remain unclear. …”

Quality and outcomes of diabetes care in patients diagnosed with cancer by Griffiths, R

“…Cancer was not associated with increased rates of microvascular or macrovascular complications, or diabetes-related mortality. …”

Hearing loss and risk of major osteoporotic fracture: a population-based cohort study in the United Kingdom by Khalid, S, Alhambra, DP, Hasheminasab, SA, Vinogradova, Y, Qureshi, N, Ratzinger, M, Brunetti, V, Salas, A, Canals, L

“…Methods: From the UK Clinical Practice Research Datalink, our cohort study matched individuals aged ≥ 60 years diagnosed with HL (READ/ICD-10 codes; 01January2001–31December2021; index event), without secondary osteoporosis causes, with up to five individuals without HL (birth, index year, sex, general practice). Incidence rates and Cox proportional hazard ratios (HL vs. no HL; stratified by low/high fracture risk) were calculated for MOF and hip fracture; multivariate logistic regression assessed risk factors for MOF and hip fracture (HL cohort). …”