Structural elucidation of estrus urinary lipocalin protein (EULP) and evaluating binding affinity with pheromones using molecular docking and fluorescence study by Rajesh, Durairaj, Muthukumar, Subramanian, Saibaba, Ganesan, Siva, Durairaj, Akbarsha, Mohammad Abdulkader, Gulyás, Balázs, Padmanabhan, Parasuraman, Archunan, Govindaraju

“…The present study provides impetus to create a point mutation for increasing longevity of EULP to develop pheromone trap for rodent pest management.…”
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Current evidence and future direction on evaluating the anticancer effects of curcumin, gingerols, and shogaols in cervical cancer: a systematic review by Rahim, Unwaniah Abdull, Mustapa, Marami, Mohamed Shakrin, Nik Noorul Shakira, Nurdin, Armania, Mohamad Taridi, Nursiati, Mohd Yusof, Yasmin Anum, Mad Nordin, Mariam Firdhaus, Che Roos, Nur Aishah

“…Only studies investigating the effects of curcumin, gingerol, shogaol, and/ or their combination in human cervical cancer cell lines and/or rodent animal models implanted with cervical cancer xenografts were included. …”
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Ocular delivery of predatory bacteria with cryomicroneedles against eye infection by Cui, Mingyue, Zheng, Mengjia, Wiraja, Christian, Chew, Sharon Wan Ting, Mishra, Arti, Mayandi, Venkatesh, Lakshminarayanan, Rajamani, Xu, Chenjie

“…The viability of B. bacteriovorus in cryoMNs remains above 80% as found in long-term storage studies, and they successfully impede the growth of gram-negative bacteria in vitro or in a rodent eye infection model. The infection is significantly relieved by nearly six times through 2.5 days of treatment without substantial effects on the cornea thickness and morphology. …”
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Characterization and gene expression analysis of the cir multi-gene family of plasmodium chabaudi chabaudi (AS) by Lawton, Jennifer, Brugat, Thibaut, Yan, Yam Xue, Reid, Adam James, Böhme, Ulrike, Otto, Thomas Dan, Pain, Arnab, Jackson, Andrew, Berriman, Matthew, Cunningham, Deirdre, Preiser, Peter Rainer, Langhorne, Jean

“…Background: The pir genes comprise the largest multi-gene family in Plasmodium, with members found in P. vivax, P. knowlesi and the rodent malaria species. Despite comprising up to 5% of the genome, little is known about the functions of the proteins encoded by pir genes. …”
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Circadian rhythm and misalignment in the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD): an experimental medicine approach by Marjot, T

“…<p>The circadian clock is an evolutionarily conserved mechanism which synchronizes physiology and behaviour across a 24-hour cycle. Rodent models have shown that hepatic lipid and glucose metabolism are under tight circadian control however translational human studies are lacking. …”

Culture of human pluripotent stem cells and neural networks in 3D using an optogenetic approach and a hydrogel model by Lee, S

“…However, calcium activity in SH-SY5Y cells was most noticeable in neurons expressing ChR2-YFP driven by the SYN1 promoter. In primary rodent neuronal cultures, synchronous calcium firing with repetitive action potentials (APs) resulted from ChR2-YFP expression was driven by both SYN1 and CaMKII promoter upon light stimulation. …”

The contribution of traumatic brain injury to Alzheimer’s disease progression by Zainal Azman, JAB

“…<p>The collective data from human and rodent studies indicate that a single traumatic brain injury (TBI) in healthy individuals can lead to an increased plaque burden, potentially accelerating the onset of Alzheimer's Disease (AD). …”

Oral mRNA delivery using capsule-mediated gastrointestinal tissue injections by Abramson, Alex, Kirtane, Ameya R., Shi, Yunhua, Zhong, Grace, Collins, Joy E., Tamang, Siddartha, Ishida, Keiko, Hayward, Alison, Wainer, Jacob, Rajesh, Netra Unni, Lu, Xiaoya, Gao, Yuan, Karandikar, Paramesh, Tang, Chaoyang, Lopes, Aaron, Wahane, Aniket, Reker, Daniel, Frederiksen, Morten Revsgaard, Jensen, Brian, Langer, Robert, Traverso, Giovanni

“…We validated the performance of formulations and devices in rodents and pigs, demonstrating protein translation in the delta, gastric, and parietal cells of the gastric mucosa, in addition to systemic uptake. …”
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In Vivo RNA Delivery to Hematopoietic Stem and Progenitor Cells via Targeted Lipid Nanoparticles by Shi, Dennis, Toyonaga, Sho, Anderson, Daniel G

“…Here, we developed a c-kit (CD117) antibody-targeted lipid nanoparticle (LNP) that, following a single intravenous injection, can deliver RNA (both siRNA and mRNA) to HSCs in vivo in rodents. This targeted delivery system does not require stem cell harvest, culture, or mobilization of HSCs to facilitate delivery. …”
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Homocysteine metabolism pathway is involved in the control of glucose homeostasis: a cystathionine beta synthase deficiency study in mouse by Cruciani-Guglielmacci, Céline, Meneyrol, Kelly, Denom, Jessica, Kassis, Nadim, Rachdi, Latif, Makaci, Fatna, Migrenne-Li, Stéphanie, Daubigney, Fabrice, Georgiadou, Eleni, Denis, Raphaël G., Sanchez-Archidona, Ana Rodriguez, Paul, Jean-Louis, Thorens, Bernard, Rutter, Guy A., Magnan, Christophe, Le Stunff, Hervé, Janel, Nathalie

“…Cystathionine beta synthase (CBS) catalyzes the first step of the transsulfuration pathway from homocysteine to cystathionine, and its deficiency leads to hyperhomocysteinemia (HHcy) in humans and rodents. To date, scarce information is available about the HHcy effect on insulin secretion, and the link between CBS activity and the setting of type 2 diabetes is still unknown. …”
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Mpox virus (MPXV): comprehensive analysis of pandemic risks, pathophysiology, treatments, and mRNA vaccine development by Eslamkhah, Sajjad, Aslan, Elif Sibel, Yavas, Cuneyd, Akcali, Nermin, Batur, Lutfiye Karcioglu, Abuaisha, Asmaa, Yildirim, Erva Esma, Solak, Mustafa, White, Kenneth

“…Initially identified in 1958, MPXV primarily spreads to humans through contact with infected wild animals, particularly rodents. Historically confined to Africa, the virus has expanded beyond endemic regions, with notable outbreaks in Europe and North America in 2022, especially among men who have sex with men (MSM). …”
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Investigating S-acylation in the metabolic dysfunction of the T2D heart by Dennis, KMJH

“…</p> <br> <p>The last part of this thesis explored alterations in CD36 in human heart failure (HF) biopsies and myocardial ischemia in rodents. In HF tissue, sarcolemmal CD36 was decreased 29% and were positively correlated with left ventricle ejection fraction (LVEF). …”

Evaluation of paper spray mass spectrometry for direct analysis of small molecule drugs and hemoglobin constant spring peptide markers by Takyi-Williams, John

“…Hence, < 10 µL blood could be sampled directly from small rodents during preclinical studies. Evaluation of the PS-MS assay to ascertain that it will provide comparable data to LC-MS/MS assay when used for in vivo bioanalytical analysis showed that PS-MS assay results correlate well with those from conventional LC-MS system, and comparable accuracy, precision, linearity and sensitivity (LLOQ of 1 ng/mL of sunitinib in DBS) were achieved with analysis speed of about 48-fold higher with sample volume of 5 µL. …”
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