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1
Characterization of the alternative splicing regulating the proapoptotic gene BIM.
Published 2012“…BCL2-homology domain 3 (BH3), essential for proapoptotic function of BIM, is included or excluded from the final BIM protein by means of alternative splicing and it is encoded in Exon 4. Therefore we hypothesized that BIM Exon 4 contains cis-acting elements - Exonic Splicing Enhancers (ESEs) or Exonic Splicing Silencers (ESSs) - , which activate or repress splicing of BIM Exon 4 respectively. …”
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Final Year Project (FYP) -
2
Identification of alternative-splicing events in human monocyte differentiation
Published 2018“…The alternative splicing of precursor messenger RNA is an important determinant of gene expression and has a prominent role in the development and homeostasis of immune cells. …”
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Final Year Project (FYP) -
3
Developing bioinformatics tools for the study of alternative splicing in eukaryotic genes
Published 2008“…Alternative splicing (AS) is a process that produces more than one protein isoform per gene in eukaryotes. …”
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Thesis -
4
Emerging functions of alternative splicing coupled with nonsense-mediated decay
Published 2015“…Higher eukaryotes rely on AS (alternative splicing) of pre-mRNAs (mRNA precursors) to generate more than one protein product from a single gene and to regulate mRNA stability and translational activity. …”
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Journal Article -
5
Identification of microRNA targets for the alternative splicing isoforms of CD46.
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Final Year Project (FYP) -
6
Interpretable Computational Modeling of pre-mRNA Splicing for Multiple Eukaryotic Species
Published 2024“…A variety of RNA sequence features influence this process, including the core splice site (SS) motifs and splicing regulatory elements (SREs), which recruit protein splicing factors. …”
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Thesis -
7
Pick one, but be quick : 5' splice sites and the problems of too many choices
Published 2014“…Splice site selection is fundamental to pre-mRNA splicing and the expansion of genomic coding potential. 5′ Splice sites (5′ss) are the critical elements at the 5′ end of introns and are extremely diverse, as thousands of different sequences act as bona fide 5′ss in the human transcriptome. …”
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Journal Article -
8
Molecular and biochemical characterisation of human casein kinase I alpha splice variants
Published 2009“…It has been shown in mammalian tissues that CKI alpha exists in two or three alternatively spliced variants (Rowles et al., 1991; Zhang et al., 1996; Kuret et al., 1997). …”
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Thesis -
9
An RRM–ZnF RNA recognition module targets RBM10 to exonic sequences to promote exon exclusion
Published 2017Subjects: Get full text
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Journal Article -
10
Alternative splicing in the DBD linker region of p63 modulates binding to DNA and iASPP in vitro
Published 2025“…The transcription factor p63 is expressed in many different isoforms as a result of differential promoter use and splicing. Some of these isoforms have very specific physiological functions in the development and maintenance of epithelial tissues and surveillance of genetic integrity in oocytes. …”
Journal article -
11
Regulation of mRNA abundance by polypyrimidine tract-binding protein-controlled alternate 5′ splice site choice
Published 2014“…Alternative splicing (AS) provides a potent mechanism for increasing protein diversity and modulating gene expression levels. …”
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Journal Article -
12
The representation of n-cutting site splicing languages for a single string with palindromic rule via de Bruijn graph
Published 2024“…Yusof-Goode (Y-G) splicing system proposed by Yusof illustrates the deoxyribonucleic acid (DNA) splicing process in a luminous way, where the rule is written in a double triple notation. …”
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Conference or Workshop Item -
13
ZAP isoforms regulate unfolded protein response and epithelial- mesenchymal transition
Published 2023Subjects: Get full text
Journal Article -
14
Molecular features underlying neurodegeneration identified through in vitro modeling of genetically diverse parkinson’s disease patients
Published 2018Subjects: Get full text
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Journal Article -
15
Durs Grünbein’s elegy for Dresden
Published 2024“…Written by someone who by dint of his date of birth was not witness to the events, the poem splices together many voices and perspectives, asking who is permitted to mourn and how, and also (explicitly) challenging conventional modes of elegy. …”
Book section -
16
Exploring the Mechanical Behavior of a Traditional Japanese Joint for Flexible Structural Design
Published 2024“…This research examines the mechanical behavior of a traditional Japanese joint, the Mortised Rabbeted Oblique (MRO) splice. Through computational simulations employing Finite Element Analysis (FEA), the study examines a continuous beam and an unmodified MRO splice, revealing expected behavior in the beam and unexpected tress concentration and displacement asymmetry in the splice. …”
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Thesis -
17
Identification of a novel mitochondria-localized LKB1 variant required for the regulation of the oxidative stress response
Published 2023“…The LKB1 gene comprises 10 exons and 9 introns. Three spliced LKB1 variants have been documented, and they reside mainly in the cytoplasm, although two possess a nuclear-localization sequence (NLS) and are able to shuttle into the nucleus. …”
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Journal Article -
18
Exposing digital image forgeries by detecting discrepancies in motion blur
Published 2012“…The widespread availability of photo manipulation software has made it unprecedentedly easy to manipulate images for malicious purposes. Image splicing is one such form of tampering. In recent years, researchers have proposed various methods for detecting such splicing. …”
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Journal Article -
19
FAIM : an antagonist of Fas-killing and beyond
Published 2020“…Faim has two alternatively spliced isoforms, with the short isoform ubiquitously expressed in various tissues and the long isoform mainly found in the nervous tissues. …”
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Journal Article -
20
Procollagen Folding in Health and Disease
Published 2024“…In Appendix C, we explore the functional differences between two alternatively spliced forms of the procollagen-II N-propeptide and speculate about the role and importance of aspartate hydroxylation in ocular function and homeostasis. …”
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Thesis