Sequence-Dependent & -Independent Effects of Intron-Mediated Enhancement (IME) by Kowal, Emma J. K.

“…We observe that even with random internal sequence, most of these introns splice well and trigger IME. In the primary tested context, the average intron stimulates an eight-fold increase in both mRNA and protein output over intronless controls, suggesting that the enhancement is largely at the level of mRNA accumulation. …”
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Cloud removal in optical remote sensing imagery based on SAR-guided inpainting using deep learning by Dou, Kaijie

“…Finally, we intercept the contamination part of the optical image with cloud occlusion from the generated image and splice it into the original image to obtain a high-resolution image with promising performance. …”
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Refining learning models in grammatical inference by Wang, Xiangrui

“…Test results based on Splice-junction Gene Sequence database demonstrate the method reduces model size by 32% from the widely used deterministic finite automaton model. …”
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Gene expression regulation by well-known non-coding RNAs by Tan, Jiazi

“…In this thesis, I studied the functions of two well-known non-coding ribonucleic acids (ncRNAs), namely U1 small nuclear ribonucleic acid (snRNA) and Xist, which exert their influence over gene expression via different pathways. 5’ splice site (5’ss) recognition by U1 snRNA binding is one of the first steps in pre-mRNA splicing, which is critical for gene expression in eukaryotes. …”
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Investigating molecular vulnerabilities in TP53-mutant transformed myeloproliferative neoplasms by Paterson, A

“…To investigate the mechanisms by which PCBP2 is required to support <em>TP53</em>-sAML, RNA-seq data from a cancer cell line model was analysed following <em>PCBP2</em> depletion for differentially expressed genes and alternative splicing events. Splice analysis showed the extent of PCBP2 regulation with a number of isoforms switching events relevant to myeloid malignancies. …”

Pattern of the strings of the n -th order limit language by Siti Hajar, Mohd Khairuddin, Muhammad Azrin, Ahmad, Noraziah, Adzhar

“…The splicing system is a study that associate with formal language theory in Mathematics and informational macromolecule in Biology. …”
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Exposing digital image forgeries by detecting discrepancies in motion blur by Kakar, Pravin, Ser, Wee, Sudha, N.

“…The widespread availability of photo manipulation software has made it unprecedentedly easy to manipulate images for malicious purposes. Image splicing is one such form of tampering. In recent years, researchers have proposed various methods for detecting such splicing. …”
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PRMT5 controls the innate immune response by Zhang, C

“…Previous replicate multivariate analysis of transcript splicing (rMATS) analysis identified a pool of genes undergoing increased intron retention with T1-44 treatment.…”

Identification of a novel mitochondria-localized LKB1 variant required for the regulation of the oxidative stress response by Tan, Ivan, Xu, Shengli, Huo, Jianxin, Huang, Yuhan, Lim, Hong-Hwa, Lam, Kong-Peng

“…The LKB1 gene comprises 10 exons and 9 introns. Three spliced LKB1 variants have been documented, and they reside mainly in the cytoplasm, although two possess a nuclear-localization sequence (NLS) and are able to shuttle into the nucleus. …”
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Compact temperature sensor with highly germania-doped fiber-based Michelson interferometer by Bao, Lifeng, Dong, Xinyong, Shum, Perry Ping, Shen, Changyu

“…It is constructed by splicing a 1-mm-long, 75 mol.% GeO2-doped fiber to a single-mode fiber and fabricating a taper at the splicing point. …”
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Proinflammatory cytokines suppress nonsense-mediated RNA decay to impair regulated transcript isoform processing in pancreatic β cells by Ghiasi, Seyed M., Marchetti, Piero, Piemonti, Lorenzo, Nielsen, Jens H., Porse, Bo T., Mandrup-Poulsen, Thomas, Rutter, Guy A.

“…Proinflammatory cytokines are implicated in pancreatic ß cell failure in type 1 and type 2 diabetes and are known to stimulate alternative RNA splicing and the expression of nonsense-mediated RNA decay (NMD) components. …”
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Interferon-α promotes HLA-B-restricted presentation of conventional and alternative antigens in human pancreatic β-cells by Carré, A, Samassa, F, Zhou, Z, Perez-Hernandez, J, Lekka, C, Manganaro, A, Oshima, M, Liao, H, Parker, R, Nicastri, A, Brandao, B, Colli, ML, Eizirik, DL, Aluri, J, Patel, D, Göransson, M, Burgos Morales, O, Anderson, A, Landry, L, Kobaisi, F, Scharfmann, R, Marselli, L, Marchetti, P, You, S, Ternette, N

“…Here we characterize the HLA-I antigen presentation in resting and IFN-α-exposed β-cells and find that IFN-α increases HLA-I expression and expands peptide repertoire to those derived from alternative mRNA splicing, protein cis-splicing and post-translational modifications. …”

Pathway and network analysis of more than 2500 whole cancer genomes by Reyna, MA, Haan, D, Paczkowska, M, Verbeke, LPC, Vazquez, M, Kahraman, A, Pulido-Tamayo, S, Barenboim, J, Wadi, L, Dhingra, P, Shrestha, R, Getz, G, Lawrence, MS, Pedersen, JS, Rubin, MA, Wheeler, DA, Brunak, S, Izarzugaza, JMG, Khurana, E, Marchal, K, von Mering, C, Sahinalp, SC, Valencia, A, PCAWG Drivers and Functional Interpretation Working Group, Reimand, J, Stuart, JM, Raphael, BJ, PCAWG Consortium

“…We find that biological processes had variable proportions of coding and non-coding mutations, with chromatin remodeling and proliferation pathways altered primarily by coding mutations, while developmental pathways, including Wnt and Notch, altered by both coding and non-coding mutations. RNA splicing is primarily altered by non-coding mutations in this cohort, and samples containing non-coding mutations in well-known RNA splicing factors exhibit similar gene expression signatures as samples with coding mutations in these genes. …”

The molecular pathogenesis of FUS mutations in amyotrophic lateral sclerosis using in vivo and in vitro models by Kent, L

“…</p> <p>The final section explores transcript levels and alternative splicing in both FUS and TDP-43 BAC transgenic mouse models. …”

Exon skipping is correlated with exon circularization by Kelly, S, Greenman, C, Cook, PR, Papantonis, A

“…However, how RNA circularization is connected to alternative splicing remains largely unexplored. Here, we stimulated primary human endothelial cells with tumor necrosis factor α or tumor growth factor β, purified RNA, generated &gt; 2.4 billion RNA-seq reads, and used a custom pipeline to characterize circular RNAs derived from coding exons. …”

Durs Grünbein’s elegy for Dresden by Leeder, K

“…Written by someone who by dint of his date of birth was not witness to the events, the poem splices together many voices and perspectives, asking who is permitted to mourn and how, and also (explicitly) challenging conventional modes of elegy. …”

Optical fiber Fabry-Perot interferometer with pH sensitive hydrogel film for hazardous gases sensing by Zheng, Yangzi, Chen, Li Han, Chan, Chi Chiu, Dong, Xinyong, Yang, Jingyi, Tou, Zhi Qiang, So, Ping Lam

“…An optical fiber Fabry-Perot interferometer (FPI) coated with polyvinyl alcohol/poly-acrylic acid (PVA/PAA) hydrogel film for toxic gases measurement has been developed. Splicing a short section of hollow core fiber between two single mode fibers forms the FPI. …”
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A compact all fiber refractive index sensor based on modal interference by Wo, Jianghai, Sun, Qizhen, Li, Xiaolei, Zhang, Jiejun, Liu, Deming, Shum, Perry Ping

“…The sensing head can be simply fabricated by splicing a section of SMF between two MMFs. Due to the different cladding modes' contribution into the interference, the transmission spectrum dips with specific interference order shifts differently with the changes of the environmental parameters. …”
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FAIM : an antagonist of Fas-killing and beyond by Huo, Jianxin, Xu, Shengli, Lam, Kong-Peng

“…Faim has two alternatively spliced isoforms, with the short isoform ubiquitously expressed in various tissues and the long isoform mainly found in the nervous tissues. …”
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Procollagen Folding in Health and Disease by Yammine, Kathryn Marie

“…In Appendix C, we explore the functional differences between two alternatively spliced forms of the procollagen-II N-propeptide and speculate about the role and importance of aspartate hydroxylation in ocular function and homeostasis. …”
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