Characterization of the alternative splicing regulating the proapoptotic gene BIM. by Lee, Qing Feng.

“…BCL2-homology domain 3 (BH3), essential for proapoptotic function of BIM, is included or excluded from the final BIM protein by means of alternative splicing and it is encoded in Exon 4. Therefore we hypothesized that BIM Exon 4 contains cis-acting elements - Exonic Splicing Enhancers (ESEs) or Exonic Splicing Silencers (ESSs) - , which activate or repress splicing of BIM Exon 4 respectively. …”
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Identification of alternative-splicing events in human monocyte differentiation by Sim, Donald Yuhui

“…During this project, 31 out of 47 splicing events were successfully validated, with SRRM2-regulated splicing events achieving a 92% validation rate. …”
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Developing bioinformatics tools for the study of alternative splicing in eukaryotic genes by Lim, Yun Ping

“…Alternative splicing (AS) is a process that produces more than one protein isoform per gene in eukaryotes. …”
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Emerging functions of alternative splicing coupled with nonsense-mediated decay by Hamid, Fursham M., Makeyev, Eugene V.

“…Higher eukaryotes rely on AS (alternative splicing) of pre-mRNAs (mRNA precursors) to generate more than one protein product from a single gene and to regulate mRNA stability and translational activity. …”
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Identification of microRNA targets for the alternative splicing isoforms of CD46. by Teo, Zhi Lin.

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Interpretable Computational Modeling of pre-mRNA Splicing for Multiple Eukaryotic Species by McCue, Kayla M.

“…A variety of RNA sequence features influence this process, including the core splice site (SS) motifs and splicing regulatory elements (SREs), which recruit protein splicing factors. …”
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Pick one, but be quick : 5' splice sites and the problems of too many choices by Roca, Xavier, Krainer, Adrian R., Eperon, Ian C.

“…Splice site selection is fundamental to pre-mRNA splicing and the expansion of genomic coding potential. 5′ Splice sites (5′ss) are the critical elements at the 5′ end of introns and are extremely diverse, as thousands of different sequences act as bona fide 5′ss in the human transcriptome. …”
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Molecular and biochemical characterisation of human casein kinase I alpha splice variants by Yong, Thomas Joon Kin.

“…It has been shown in mammalian tissues that CKI alpha exists in two or three alternatively spliced variants (Rowles et al., 1991; Zhang et al., 1996; Kuret et al., 1997). …”
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An RRM–ZnF RNA recognition module targets RBM10 to exonic sequences to promote exon exclusion by Collins, Katherine M., Kainov, Yaroslav A., Christodolou, Evangelos, Ray, Debashish, Morris, Quaid, Hughes, Timothy, Taylor, Ian A., Makeyev, Eugene V., Ramos, Andres

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Alternative splicing in the DBD linker region of p63 modulates binding to DNA and iASPP in vitro by Lotz, R, Osterburg, C, Chaikuad, A, Weber, S, Akutsu, M, Machel, AC, Beyer, U, Gebel, J, Löhr, F, Knapp, S, Dobbelstein, M, Lu, X, Dötsch, V

“…Moreover, the concomitant loss of the charged amino acids in the alternatively spliced version decreases the affinity of p63 to its cognate DNA element two- to threefold. mRNAs encoding full-length p63, as well as its alternatively spliced version, are present in all tissues that we investigated, albeit in differing ratios. …”

Regulation of mRNA abundance by polypyrimidine tract-binding protein-controlled alternate 5′ splice site choice by Hamid, Fursham M., Makeyev, Eugene V.

“…How alternate splice sites are selected by the splicing machinery and how AS is integrated into gene regulation networks remain important questions of eukaryotic biology. …”
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The representation of n-cutting site splicing languages for a single string with palindromic rule via de Bruijn graph by Mohd Ruslim, Nooradelena, Yuhani, Yusof, Mohd Sham, Mohamad

“…Yusof-Goode (Y-G) splicing system proposed by Yusof illustrates the deoxyribonucleic acid (DNA) splicing process in a luminous way, where the rule is written in a double triple notation. …”
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ZAP isoforms regulate unfolded protein response and epithelial- mesenchymal transition by Ly, Phuong Thao, Xu, Shaohai, Wirawan, Melissa, Luo, Dahai, Roca, Xavier

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Molecular features underlying neurodegeneration identified through in vitro modeling of genetically diverse parkinson’s disease patients by Lin, Lin, Göke, Jonathan, Cukuroglu, Engin, Dranias, Mark R., VanDongen, Antonius M.J., Stanton, Lawrence W.

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Identification of a novel mitochondria-localized LKB1 variant required for the regulation of the oxidative stress response by Tan, Ivan, Xu, Shengli, Huo, Jianxin, Huang, Yuhan, Lim, Hong-Hwa, Lam, Kong-Peng

“…The LKB1 gene comprises 10 exons and 9 introns. Three spliced LKB1 variants have been documented, and they reside mainly in the cytoplasm, although two possess a nuclear-localization sequence (NLS) and are able to shuttle into the nucleus. …”
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Procollagen Folding in Health and Disease by Yammine, Kathryn Marie

“…In Appendix C, we explore the functional differences between two alternatively spliced forms of the procollagen-II N-propeptide and speculate about the role and importance of aspartate hydroxylation in ocular function and homeostasis. …”
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FAIM : an antagonist of Fas-killing and beyond by Huo, Jianxin, Xu, Shengli, Lam, Kong-Peng

“…Faim has two alternatively spliced isoforms, with the short isoform ubiquitously expressed in various tissues and the long isoform mainly found in the nervous tissues. …”
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Seismic behavior of interior concretebeam-column joints with non-seismic and limited seismic detailing by Li, Qingyuan.

“…Column main bars lap spliced within plastic hinge regions were detrimental. …”
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Investigating the human teashirt genes TSHZ2 and TSHZ3 in pancreatic and endocrine lineage commitment using genome modified human embryonic stem cells (hESC) by Eng, Shermaine Zi Hui

“…To better understand the role of these genes in human pancreatic development, the expression of TSHZ2 Variant 1 and TSHZ3 was characterized, revealing a novel spliced variant of TSHZ2 Variant 1. The CRISPR RNA-guided FokI-dCas9 nuclease (RFN) genome editing system was employed to create loss-of-function hESC lines. …”
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Exposing digital image forgeries by detecting discrepancies in motion blur by Kakar, Pravin, Ser, Wee, Sudha, N.

“…The widespread availability of photo manipulation software has made it unprecedentedly easy to manipulate images for malicious purposes. Image splicing is one such form of tampering. In recent years, researchers have proposed various methods for detecting such splicing. …”
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