Computational analysis and prediction of specific genomic regions forming R-loop structure and chromosomal variations associated with cancer by Wongsurawat, Thidathip

“…Integrative genomics analyses suggested that RLFSs could play a role in gene regulation, AID/APOBEC-mediated editing/mutagenesis, alternative splicing, and epigenetic modifications, and also associate with mutations in cancer, neurodegenerative diseases and mental disorders. …”
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Potential ago2/miR-3068-5p cascades in the nucleus accumbens contribute to methamphetamine-induced locomotor sensitization of mice by Liu, Dan, Liang, Min, Zhu, Li, Zhou, Ting-Ting, Wang, Yu, Wang, Rui, Wu, Fei-Fei, Goh, Eyleen Lay Keow, Chen, Teng

“…Argonaute2 (Ago2), a specific splicing protein involved in the generation of miRNA, was found to be dysregulated in the nucleus accumbens (NAc) of methamphetamine (METH)-sensitized mice in our previous study. …”
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Investigating molecular vulnerabilities in TP53-mutant transformed myeloproliferative neoplasms by Paterson, A

“…To investigate the mechanisms by which PCBP2 is required to support <em>TP53</em>-sAML, RNA-seq data from a cancer cell line model was analysed following <em>PCBP2</em> depletion for differentially expressed genes and alternative splicing events. Splice analysis showed the extent of PCBP2 regulation with a number of isoforms switching events relevant to myeloid malignancies. …”

Inhibitory Potential of the Truncated Isoforms on Glutamate Transporter Oligomerization Identified by Computational Analysis of Gene-Centric Isoform Maps by Karagöl, Alper, Karagöl, Taner, Li, Mengke, Zhang, Shuguang

“…Conclusion Our computational studies on glutamate transporters offer insights into the roles of alternative splicing on protein interactions and identifies potential drug targets for physiological or pathological processes.…”
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Pan-cancer analysis of whole genomes by ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium

“…A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter; identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation; analyses timings and patterns of tumour evolution; describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity; and evaluates a range of more-specialized features of cancer genomes.…”

Runx family genes in a cartilaginous Fish, the elephant Shark (Callorhinchus milii) by Nah, Giselle Sek Suan, Lim, Zhi Wei, Tay, Boon-Hui, Osato, Motomi, Venkatesh, Byrappa

“…Through the use of alternative promoters and/or alternative splicing, each of the elephant shark Runx genes expresses multiple isoforms similar to their orthologs in human and other bony vertebrates. …”
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Sequence-Dependent & -Independent Effects of Intron-Mediated Enhancement (IME) by Kowal, Emma J. K.

“…We observe that even with random internal sequence, most of these introns splice well and trigger IME. In the primary tested context, the average intron stimulates an eight-fold increase in both mRNA and protein output over intronless controls, suggesting that the enhancement is largely at the level of mRNA accumulation. …”
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Cloud removal in optical remote sensing imagery based on SAR-guided inpainting using deep learning by Dou, Kaijie

“…Finally, we intercept the contamination part of the optical image with cloud occlusion from the generated image and splice it into the original image to obtain a high-resolution image with promising performance. …”
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Wolbachia-mosquito interactions and engineered female-specific lethality for Aedes-arbovirus control by Molloy, JC

“…In Chapter 4, I engineer female-specific, late-acting lethality in <em>Ae. aegypti</em> using specific effectors crossed with candidate pupal-stage promoters and a <em>doublesex</em> cassette causing sexspecific splicing. In Chapter 5, I transform and characterise <em>Ae. aegypti</em> lines producing sex-specific <em>Drosophila melanogaster</em> alcohol dehydrogenase (<em>Adh</em>) to evaluate potential for early-stage inducible genetic sexing. …”

Refining learning models in grammatical inference by Wang, Xiangrui

“…Test results based on Splice-junction Gene Sequence database demonstrate the method reduces model size by 32% from the widely used deterministic finite automaton model. …”
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基于高掺锗石英光纤的中红外超连续谱产生 = Mid-infrared supercontinuum generation with highly germanium-doped silica fiber by 朱磊 Zhu Lei, 王鹿鹿 Wang Lulu, 董新永 Dong Xinyong, 沈平 Shen Ping, 苏海斌 Su Haibin

“…The free space coupling efficiency from the pump laser to the germanium-doped fiber is enhanced by fusion-splicing a 100~200 μm long multimode fiber. Length of germanium-doped fiber is optimized. …”
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Securing untrusted memories in embedded systems by Vig, Saru

“…This thesis aims to address this challenge by proposing compile-time and runtime strategies for securing untrusted memories from active memory attacks (e.g. replay, spoo ng and splicing attacks) that can compromise the con dentiality and integrity of the memory data. …”
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Conformational design characterization of a truncated diamine oxidase by Razali, Nur Nadia

“…The domain 4 that contained the active site was selected for the splicing process in order to retain the enzyme’s active site. …”
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