Targeted hematopoietic stem cell depletion through SCF-blockade by Chan, Yan Y., Ho, Pui Y., Dib, Carla, Swartzrock, Leah, Rayburn, Maire, Willner, Hana, Ko, Ethan, Ho, Katie, Down, Julian D., Wilkinson, Adam C., Nakauchi, Hiro, Denis, Morgane, Cool, Taylor, Czechowicz, Agnieszka

“…This combination was the only non-genotoxic conditioning approach that enabled robust donor engraftment post HSCT in WT mice. Conclusion These findings shed new insights into the mechanism of αCD117 mAb-mediated HSC depletion. …”
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Exploring and Exploiting Ribonuclease 1: from Protein Biochemistry to Protein Engineering by Wralstad, Evans Christian

“…Sulfur–arene interactions appear to tune the reactivity of methionine residues in a manner consistent with rates of oxidation. These findings highlight an underappreciated role for methionine—to protect catalytic histidine residues—and indicate a means by which ptRNases remain functional in oxidatively challenging physiological environments. …”
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Boon or bane? : The role of filial piety, relationship quality, caregiver gender on work-family interface among working caregivers of the elderly by Leong, Anthony Xueheng

“…This is the first study to examine the relationship between the multi-dimensional filial piety and the work-family interface among working caregivers of the elderly, with considerations of relationship quality and gender. Findings point to potential directions for future research and offer suggestions on how to aid working caregivers to optimize interactions between work and family domains. …”
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Metal-organic architectures driven by a multifunctional 6-aminouracil spacer : structures, noncovalent interactions, and conductivity by Purkayastha, Atanu, Dhar, Sourab, Mondal, Suvra Prakash, Franconetti, Antonio, Frontera, Antonio, Ganguly, Rakesh, Kirillov, Alexander M., Misra, Tarun Kumar

“…The computational study for molecular electrostatic potential (MEP) surface energies revealed an important finding, namely a decrease of the π-acidity of the uracil ring upon coordination and a consequent increase of the π-basicity of the phenyl-sulfonate ring, resulting in effective anti-parallel π–π stacking interactions in 1 and 2. …”
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Preliminary environmental risk consideration for small UAV ground risk mapping by Chung, Han Jie, Mohd Hasrizam Che Man, Sivakumar, Anush Kumar, Low, Kin Huat

“…The regions with high rainfall, increased bird population per site and strong signal interference can be extracted.These high-risk locations can be expected to be more hazardous for sUAVs to fly in. Findings for environmental risk-tiering and risk-mapping are preliminary and based on the available environmental data as identified in this study. …”
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Lactate cross-feeding between Bifidobacterium species and Megasphaera indica contributes to butyrate formation in the human colonic environment by Zhao, Sainan, Lau, Raymond, Zhong, Yang, Chen, Ming-Hsu

“…We concluded that lactate generated by Bifidobacterium through catabolizing xylose fueled the growth of M. indica and triggered the synthesis of butyrate. Our findings demonstrated a novel cross-feeding mechanism to generate butyrate in the human colon. …”
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Sentiment analysis and summarization of movie reviews across genres. by Tun, Thura Thet.

“…Graphical representation methods such as sentiment bar, sentiment meter, thumbs up/down, sentiment term cloud, sentiment treemap, sentiment time series, aspect-based sentiment summarization and sentiment link analysis graph (named SentiGraph) were implemented and evaluated. The evaluation findings indicate that the participants were generally satisfied with the results of sentiment summarization, and found the proposed approach novel and useful. …”
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Growth and physical properties of organic semiconducting single crystals by Tan, Ke Jie

“…Therefore, experimental studies aids in finding parameters responsible for the physical properties of materials. …”
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New multi-target based therapeutics against an opportunistic superbug by Premkumar, Jayaraman.

“…Additionally, expansion of the phytochemical-antibiotic interaction profiles were also carried out with various classes of antibiotics and phytochemicals to understand the interaction patterns by establishing a novel interaction network that provides a baseline to identify the mechanism of action of the phytochemicals and molecular mechanism of synergy. The above findings have potential implications in delaying the development of resistance as the antibacterial effect is achieved with lower concentrations of both drugs (antibiotics and phytochemicals). …”
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Improved life cycle assessment for desalination : handling the choices and uncertainties by Zhou, Jin

“…The system boundary and characterization approach was selected based on our previous findings. This work provided the environment profile of Singapore’s desalinations with improved reliability. …”
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Occurrence, human exposure and dynamics of phthalates in ACMV indoor environments : method development and field studies by Chen, Ailu

“…The increases are because of either resuspension of phthalates bound to settled dust or partitioning of gas-phase phthalates to the airborne particles. The findings also demonstrate that the gas fractions of the low-volatile phthalates decrease when the airborne particle concentrations increase.…”
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先秦思想中音乐与情感的关系 ：以《孟子》《庄子》“乐”（lè）与 “乐” （yuè）的运用为核心 = The relations between music and emotion in Pre-Qin thought : an analysis of the usage of ‘Lè’ and ‘Yuè’ in the Mencius and the Zh... by 何昱慧 Ho, Adeline Yu Hui

“…Understanding the relations between“乐” and Music and Emotions in Pre-Qin text are necessary in finding the underlying significance. On the other hand, it also helps in the analysis of ideology promoted to shape the society at that point of time, which is beneficial to the progress of research in the topic.…”
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新加坡当代社会同志自由的研究 = A study of homosexuals’ liberty in present day Singapore by 陈惠嫔 Tan, Mabel Hui Ping

“…Analysis of credible survey results and reports, as well as gathering personal anecdotes and surveys from respondents was done. Findings were analyzed in an attempt to understand and explain how the tension between the individuals and society at large works. …”
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Aircraft noise, overheating and poor air quality in London primary schools' classrooms by Montazami, Azadeh

“…It is shown in this study that overheating and air quality benchmarks which are proposed by 'Department for Education and Skills' in Building Bulletin 101 and used to design and refurbish the UK schools, are relaxed benchmarks in comparison with the others which are proposed by different organisations and researchers. The overall findings of this thesis have been developed to draw the attention of school designers' to the current and future potential conflicts between the comfort factors in schools' classrooms. …”
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Neuronal control of cardiac excitability in pro-hypertensive states by Larsen, H

“…</p> <p><b>Chapter 7</b> forms the concluding discussion that summarises the main findings of this thesis and attempt to place it in a clinical context, and highlights avenues of further research. …”

Outcomes of shoulder replacement surgery in routine care by Craig, RS

“…The available studies were of low quality and produced few reliable findings to inform practice. RCTs provided very little useful data on the rates of revision surgery and adverse events. …”

Sexual violence at higher education institutions: prevalence, nature, and opportunities for prevention by Steele, B

“…I also encountered significant political sensitivities with regard to reporting the findings to relevant stakeholders, potentially threatening the ability of internal researchers to carry out such research, as suggested by Universities UK. …”

Global, regional, and national burden of disorders affecting the nervous system, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021 by Steinmetz, JD, Seeher, KM, Schiess, N, Bennett, DA, Maude, RJ, Newton, CRJ, Rodriguez, JAB

“…A comorbidity correction was used to calculate total prevalence of all conditions that affect the nervous system combined. <p><b>Findings</b></p> Globally, the 37 conditions affecting the nervous system were collectively ranked as the leading group cause of DALYs in 2021 (443 million, 95% UI 378–521), affecting 3·40 billion (3·20–3·62) individuals (43·1%, 40·5–45·9 of the global population); global DALY counts attributed to these conditions increased by 18·2% (8·7–26·7) between 1990 and 2021. …”

Developing optogenetics for use in vascular research by Rorsman, N

“…The overall aim of this thesis was to establish ChR2 for use in vascular optogenetics. The main findings of this thesis are:</p> <p>1) Blue light activation of ChR2 and the ChR2 variant ChR2(H134R) led to long-lasting and non-inactivating depolarising currents. …”

Pathogen diversity and antimicrobial resistance transmission of Salmonella enterica serovars Typhi and Paratyphi A in Bangladesh, Nepal, and Malawi: a genomic epidemiological study... by Dyson, ZA, Ashton, PM, Khanam, F, Chunga Chirambo, A, Shakya, M, Meiring, JE, Tonks, S, Karkey, A, Msefula, C, Clemens, JD, Dunstan, SJ, Baker, S, Dougan, G, Pitzer, VE, Basnyat, B, Qadri, F, Heyderman, RS, Gordon, MA, Holt, KE, Pollard, AJ, STRATAA Study Group

“…</p> <br> <p><strong>Findings:</strong> We sequenced 731 genomes from isolates obtained during surveillance across the three sites between Oct 1, 2016, and Aug 31, 2019 (24 months in Dhaka and Kathmandu and 34 months in Blantyre). …”