Nanoparticle-induced chemoresistance: the emerging modulatory effects of engineered nanomaterials on human intestinal cancer cell redox metabolic adaptation by Wu, Zhuoran, Setyawati, Magdiel Inggrid, Lim, Hong Kit, Ng, Kee Woei, Tay, Chor Yong

“…Transcriptome profiling, bioinformatics analysis and siRNA gene knockdown experiments revealed the nuclear factor erythroid 2-related factor 2 (Nrf2) as the key modulator of the ZnO NP-induced drug resistance. Our findings suggest that a ROS-inducing ENM can emerge as a nano-stressor, capable of regulating the chemosensitivity of colon cancer cells.…”
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Super-resolution imaging of photogenerated charges on CdS/g-C₃N₄ heterojunctions and its correlation with photoactivity by Wu, Shuyang, Lee, Jinn-Kye, Lim, Pei Chong, Xu, Rong, Zhang, Zhengyang

“…The photoactive species (i.e., e- and h+) were found to be preferentially distributed at the two end segments of CdS nanorods and the edge boundaries of g-C3N4. Therefore, our findings shed more light on the charge distribution and photocatalytic heterogeneity of composite materials at the nanoscale. …”
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Time-restricted feeding modulates the DNA methylation landscape, attenuates hallmark neuropathology and cognitive impairment in a mouse model of vascular dementia by Selvaraji, Sharmelee, Efthymios, Motakis, Foo, Roger Sik Yin, Fann, David Y., Lai, Mitchell Kim Peng, Chen, Christopher Li Hsian, Lim, Kah-Leong, Arumugam, Thiruma V.

“…Modulation of DNA methylation patterns in the cortex of AL CCH mice was re-modelled and signs of reversal was observed in IF CCH mice across all three timepoints. Conclusions: These findings provide an understanding of how IF may protect the brain against damage caused by CCH and show promise in offering potential beneficial effects in mitigating the neuropathology and cognitive deficits in VaD.…”
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Parent-infant affect synchrony during social and solo play by Kidby, Sayaka, Neale, Dave, Wass, Sam, Leong, Victoria

“…While our sample was small and from a homogeneous population (e.g. white, highly educated parents), limiting the implications of the findings, these results demonstrate that maternal active engagement in playful interaction with her infant affords, increases, and extends infant positive affect and parent-infant positive affect synchrony, providing insights into how the social context modulates infants' affective experiences. …”
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2D-3D perovskite memristor with low energy consumption and high stability for neural morphology calculation by Sun, Kaixuan, Wang, Qingrui, Zhou, Long, Wang, Jingjuan, Chang, Jingjing, Guo, Rui, Tay, Beng Kang, Yan, Xiaobing

“…Moreover, this perovskite-based artificial synapse has ultra-low power consumption due to the switchable p-i-n structure in organic-inorganic halide perovskites. Our finding highlights the immense application potential of the 2D-3D perovskite memristor in the future neuromorphic computing system.…”
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Constrained neuro fuzzy inference methodology for explainable personalised modelling with applications on gene expression data by Singh, Balkaran, Doborjeh, Maryam, Doborjeh, Zohreh, Budhraja, Sugam, Tan, Samuel, Sumich, Alexander, Goh, Wilson, Lee, Jimmy, Lai, Edmund, Kasabov, Nikola

“…These genes are linked to cognitive ability and impulsive behaviour. Our findings suggest a significant starting point for further research into the biological role of cognitive and impulsivity-related differences. …”
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Valley-optical absorption in planar transition metal dichalcogenide superlattices by Hashemi, R., Shojaei, S., Rezaei, B., Liu, Zheng

“…Moreover, the role of incident light angle and light polarization were studied in details at different valleys of [Formula: see text] and [Formula: see text]. The most important finding is that by changing the polarization of incident light, it is possible to increase the absorption coefficients of [Formula: see text] and [Formula: see text] valleys by up to 30 times. …”
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LKAW: a robust watermarking method based on large kernel convolution and adaptive weight assignment by Zhang, Xiaorui, Jiang, Rui, Sun, Wei, Song, Aiguo, Wei, Xindong, Meng, Ruohan

“…Robust watermarking requires finding invariant features under multiple attacks to ensure correct extraction. …”
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Waste to wealth: near-infrared/pH dual-responsive copper-humic acid hydrogel films for bacteria-infected cutaneous wound healing by Zha, Kangkang, Xiong, Yuan, Zhang, Wenqian, Tan, Meijun, Hu, Weixian, Lin, Ze, Cheng, Peng, Lu, Li, Cai, Kaiyong, Mi, Bobin, Feng, Qian, Zhao, Yanli, Liu, Guohui

“…This PVA@Cu-HAs NPs@SEW hydrogel film improves tissue regeneration by promoting M2 macrophage polarization, alleviating oxidative stress, enhancing angiogenesis, and facilitating collagen deposition. These findings highlight the therapeutic potential of PVA@Cu-HAs NPs@SEW hydrogel film for the treatment of bacterially infected cutaneous wound healing.…”
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Topography-incorporated adjoint-state surface wave Traveltime tomography: method and a case study in Hawaii by Hao, Shijie, Chen, Jing, Xu, Mijian, Tong, Ping

“…Additionally, our model reveals a high-velocity anomaly to the South of Hualalai's summit, which may be related to a buried rift zone. Our findings further demonstrate that including topography can lead to a correction of up to 0.8% in the shear wave velocity model of Hawaii, an island spanning approximately 100 km with volcanoes reaching elevations exceeding 4 km.…”
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Impact of China's financial development on the sustainable development goals of the Belt and Road Initiative participating countries by Li, Chenggang, Zhao, Gang, Koh, Keumseok Peter, Xu, Zhenci, Yue, Mu, Wang, Weiyan, Tan, Yuanyuan, Wu, Liang

“…To address this gap, we utilized panel regression models to quantitatively assess the impact of China’s financial development scale, structure, and efficiency on the SDGs of the BRI participating countries, and adopted Geographically and Temporally Weighted Regression (GTWR) model to explore the spatial-temporal effects of China’s financial development scale, structure, and efficiency on the SDGs of the BRI participating countries. Our findings indicate that China’s financial development has significantly promoted the SDGs of the BRI participating countries. …”
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Electrocatalytic reduction of simulated industrial CO2 and CO mixtures: revising chronoamperometry to enable selective gas mixture reduction via cyclic voltammetry by Chen, Wen Qian, Foo, Cyrus Jit Loong, Ge, Liya, Veksha, Andrei, Chan, Wei Ping, Shen, Yafei, Lisak, Grzegorz

“…Meanwhile, the results underscored the dependency of performance enhancement on the scan rate of cycling, revealing plausible correlations with mass transfer and electrode surface dynamics. Furthermore, the findings indicated that the selectivity towards HCOOH and C2H4 is closely related to the CO2/CO ratios of gas sources. …”
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Correlates of lifestyle patterns among children in Singapore aged 10 years: the growing up in Singapore towards healthy outcomes (GUSTO) study by Tan, Sarah Yi Xuan, Chia, Airu, Tai, Bee Choo, Toh, Jia Ying, Colega, Marjorelee, Padmapriya, Natarajan, Setoh, Peipei, Kee, Michelle Zhi Ling, Yuan, Wen Lun, Lee, Yung Seng, Loo, Benny Kai Guo, Yap, Fabian Kok Peng, Tan, Kok Hian, Godfrey, Keith M., Chong, Yap Seng, Eriksson, Johan, Müller-Riemenschneider, Falk, Chong, Mary Foong-Fong

“…Having siblings, pet ownership, mother’s physical activity, parenting style, parental bonding, child’s outdoor time, and breakfast consumption were not associated with children’s lifestyle patterns. Conclusions: These findings provide direction for future interventions by identifying vulnerable groups and contexts that should be prioritised.…”
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Imprinting of IgA responses in previously infected individuals receiving bivalent mRNA vaccines (WT and BA.4/BA.5 or WT and BA.1) by Goh, Yun Shan, Fong, Siew-Wai, Hor, Pei Xiang, Loh, Chiew Yee, Tay, Matthew Zirui, Wang, Bei, Salleh, Siti Nazihah Mohd, Ngoh, Eve Zi Xian, Lee, Raphael Tze Chuen, Poh, Xuan Ying, Lee, I. Russel, Rao, Suma, Chia, Po Ying, Maurer-Stroh, Sebastian, Wang, Cheng-I, Leo, Yee Sin, Lye, David C., Young, Barnaby Edward, Ng, Lisa F. P., Renia, Laurent

“…The relative fold change in serum binding IgA response was more skewed towards WT over variant (BA.1, BA.5 or EG.5.1) spike in previously infected bivalent-booster-vaccinees, as compared with previously infected monovalent-(WT)-booster-vaccinees. Conclusion: The findings suggest imprinting of antibody responses that is shaped by the first vaccination (WT spike). …”
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Early Prediction of Skin Viability Using Visible Diffuse Reflectance Spectroscopy and Autofluorescence Spectroscopy by Zhu, Caigang, Chen, Shuo, Chui, Christopher Hoe-Kong, Tan, Bien-Keem, Liu, Quan

“…Meanwhile, several physiologically relevant parameters including hemoglobin oxygenation, total hemoglobin concentration, and redox ratio indicators estimated from diffuse reflectance and autofluorescence spectra show distinctively different trends over time for nonviable and viable skin. Conclusions: These findings will be helpful to clinicians for making a precise judgment on flap viability. …”
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Heme-Regulated eIF2α Kinase Modulates Hepatic FGF21 and is Activated by PPARβ/δ Deficiency by Zarei, Mohammad, Barroso, Emma, Leiva, Rosana, Barniol-Xicota, Marta, Pujol, Eugènia, Escolano, Carmen, Vázquez, Santiago, Palomer, Xavier, Pardo, Virginia, González-Rodríguez, Águeda, Valverde, Ángela M., Quesada-López, Tania, Villarroya, Francesc, Wahli, Walter, Vázquez-Carrera, Manuel

“…Moreover, pharmacological activation of HRI increased Fgf21 expression and reduced lipid-induced hepatic steatosis and glucose intolerance and these effects were not observed in Fgf21-null mice. Overall, these findings suggest that HRI is a potential target for regulating hepatic FGF21 levels.…”
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Hypoxia-inducible factor-2 alpha up-regulates CD70 under hypoxia and enhances anchorage-independent growth and aggressiveness in cancer cells by Kitajima, Shojiro, Lee, Kian Leong, Fujioka, Masaki, Sun, Wendi, You, Jia, Chia, Grace Sushin, Wanibuchi, Hideki, Tomita, Shuhei, Araki, Marito, Kato, Hiroyuki, Poellinger, Lorenz

“…In addition, the expression of CD70 and colony forming efficiency in soft agar were decreased by knockdown of HIF-2α. These findings indicate that CD70 expression and an aggressive phenotype of cancer cells is driven under hypoxic conditions and mediated by HIF-2α functions and epigenetic modifications. …”
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Ethnic differences in knowledge, attitudes, and practices related to dietary salt intake and association with hypertension in Malaysia: a multi-centre cross-sectional study by Chia, Yook Chin, Ching, Siew Mooi, Chew, Ming Tsuey, Devaraj, Navin Kumar, Oui, Jethro Ee Keat, Lim, Hooi Min, Chew, Bee Nah, Mohamed, Mohazmi, Ooi, Pei Boon, Cheng, Maong Hui, Beh, Hooi Chin, Chung, Felicia Fei-Lei

“…Those who were unaware of the difference between salt and sodium and who reported not reading salt labels had higher odds of having elevated blood pressure. These findings demonstrate that while there is a suboptimal translation of salt knowledge into practice in Malaysia, with significant differences in KAP observed between ethnic groups, the potential of improving health outcomes by improving the clarity and awareness of salt labels is substantial. …”

Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 co... by Ferrari, AJ, Santomauro, DF, Aali, A, Lacey, BWH, Rodriguez, JAB

“…A global epidemiological transition remains underway. Our findings suggest that prioritising non-communicable disease prevention and treatment policies, as well as strengthening health systems, continues to be crucially important. …”

Halal beauty supply chain and sustainable operational excellence: A moderator of the post-SARS-CoV-2 mitigation strategy by Fernando, Yudi, Mergeresa, Fineke, Ika Sari, Wahyuni-TD, Nurul Sabrina, Hazarasim

“…This study used a structural equation modeling technique to test the validity of the research model and hypotheses. Findings: This study found that halal transportation, halal manufacturing, halal packaging and post-SARS-CoV-2 mitigation strategies had a significant and direct effect on SOE. …”
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