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R-loopDB: a database for R-loop forming sequences (RLFS) and R-loops
Published 2017Subjects: Get full text
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Journal Article -
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Improving gene therapy
Published 2009“…Retroviral mediated gene therapy has progressed along with advances in biological science. …”
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Final Year Project (FYP) -
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Characterization and gene expression analysis of the cir multi-gene family of plasmodium chabaudi chabaudi (AS)
Published 2013“…Background: The pir genes comprise the largest multi-gene family in Plasmodium, with members found in P. vivax, P. knowlesi and the rodent malaria species. …”
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Journal Article -
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YY1 binding is a gene-intrinsic barrier to Xist-mediated gene silencing
Published 2024“…X chromosome inactivation (XCI) in mammals is mediated by Xist RNA which functions in cis to silence genes on a single X chromosome in XX female cells, thereby equalising levels of X-linked gene expression relative to XY males. …”
Journal article -
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Nano-bioceramic for gene delivery
Published 2013“…This study explored the ability of nano-sized bio-ceramic particles to act as synthetic gene carriers. [5th Award]…”
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Student Research Poster -
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Gene and sample selection for cancer identification
Published 2011“…This further raises an issue of stability of a gene selection method because a gene selection method should be repeatable and reproducible, giving high confidence for selected genes. …”
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Thesis -
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Identifying genes in Parkinson’s disease : state of the art
Published 2020“…However, most sporadic PD cannot be accounted for by known familial PD genes, with the late-onset nature of PD making further linkage studies challenging. …”
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Journal Article -
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CRISPR-Cas9-mediated gene editing of MYB28 genes impair glucoraphanin accumulation of Brassica oleracea in the field
Published 2021“…These results demonstrate the potential of gene-editing approaches to translate discoveries in fundamental biological processes for improved crop performance.…”
Journal article -
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Doppelgänger spotting in biomedical gene expression data
Published 2023“…Applying doppelgangerIdentifier across a multitude of diseases and data types, we show the pervasive nature of DEs in biomedical gene expression data. We also provide guidelines toward proper doppelgänger identification by exploring the ramifications of lingering batch effects from batch imbalances on the sensitivity of our doppelgänger identification algorithm. …”
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Journal Article -
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Hox gene expression in early zebrafish embryo
Published 2015“…Embryogenesis is a tightly controlled process which involves a plethora of transcription factors to ensure proper development. One group of genes involved in embryogenesis is Hox genes which encode for transcription factors and help in anterior-posterior patterning at post-gastrulation time. …”
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Final Year Project (FYP) -
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Unravelling gene regulation in the epidermis during differentiation
Published 2018“…This study has paved ways to understand the critical role of polyamines in the epidermis and the complexity of the gene regulatory network that drives keratinocyte differentiation.…”
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Thesis-Doctor of Philosophy -
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Development of CRISPR gene therapy for retinal degenerations
Published 2021“…Gene-supplementation therapies using adeno-associated viral (AAV) vectors have been developed, however, they are limited to the treatment of recessive IRDs and genes with small coding sequences. …”
Thesis -
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The molecular determinants of Polycomb-mediated gene repression
Published 2019“…<p>Precise spatio-temporal regulation of gene expression is required for development of multicellular organisms. …”
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Reasons and reproduction: gene editing and genetic selection
Published 2023“…Many writers in bioethics, science, and medicine contend that embryo selection is a morally better way of avoiding genetic disorders then gene editing, as the latter has risks that the former does not. …”
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Gene loops juxtapose promoters and terminators in yeast.
Published 2004“…These data suggest that gene loops are involved in the early stages of transcriptional activation. …”
Journal article