Unlocking the Secrets of Cancer Stem Cells with γ-Secretase Inhibitors: A Novel Anticancer Strategy by Maryam Ghanbari-Movahed, Zahra Ghanbari-Movahed, Saeideh Momtaz, Kaitlyn L. Kilpatrick, Mohammad Hosein Farzaei, Anupam Bishayee

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Editorial: Plant-based bioactive compounds: natural tumor prevention? by Hui Jia, Mei Feng

Subjects: “…γ-secretase/Notch pathway…”
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Soluble Gamma-secretase Modulators Attenuate Alzheimer's β-amyloid Pathology and Induce Conformational Changes in Presenilin 1 by Frank Raven, Joseph F. Ward, Katarzyna M. Zoltowska, Yu Wan, Enjana Bylykbashi, Sean J. Miller, Xunuo Shen, Se Hoon Choi, Kevin D. Rynearson, Oksana Berezovska, Steven L. Wagner, Rudolph E. Tanzi, Can Zhang

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Targeting Amyloidogenic Processing of APP in Alzheimer’s Disease by Jing Zhao, Xinyue Liu, Weiming Xia, Weiming Xia, Yingkai Zhang, Chunyu Wang, Chunyu Wang, Chunyu Wang

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γ‐Secretase inhibitors in cancer clinical trials are pharmacologically and functionally distinct by Yong Ran, Fokhrul Hossain, Antonio Pannuti, Christian B Lessard, Gabriela Z Ladd, Joo In Jung, Lisa M Minter, Barbara A Osborne, Lucio Miele, Todd E Golde

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Liraglutide improves cognition function in streptozotocin-induced diabetic rats by downregulating β-secretase and γ-secretase and alleviating oxidative stress in HT-22 cells by Lou-yan Ma, Song-fang Liu, Zheng-quan Ma, Ya-gang Guo, Mo Li, Yuan Gao, Yu-ting Wen, Yu Niu, Hai-xia Sui, Bao-shan Li, Ya Li, Ya-li Lv, Yao Huang, Jia-jia Zhai

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BACE-1 and γ-Secretase as Therapeutic Targets for Alzheimer’s Disease by Miguel A. Maia, Emília Sousa

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Development of a High-Throughput Assay for Screening of γ-Secretase Inhibitor with Endogenous Human, Mouse or Drosophila γ-Secretase by Lie-Feng Wang, Xin Xie, Ru Zhang

Subjects: “…γ-secretase inhibitor…”
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Loss of presenilin function enhances tau phosphorylation and aggregation in mice by Carlos M. Soto-Faguás, Paula Sanchez-Molina, Carlos A. Saura

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Modulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice by Rogers Kathryn, Felsenstein Kevin M, Hrdlicka Lori, Tu Zhiming, Albayya Faris, Lee Winnie, Hopp Sarah, Miller Mary-Jo, Spaulding Darcie, Yang Zhiyong, Hodgdon Hilliary, Nolan Scott, Wen Melody, Costa Don, Blain Jean-Francois, Freeman Emily, De Strooper Bart, Vulsteke Veerle, Scrocchi Louise, Zetterberg Henrik, Portelius Erik, Hutter-Paier Birgit, Havas Daniel, Ahlijanian Michael, Flood Dorothy, Leventhal Liza, Shapiro Gideon, Patzke Holger, Chesworth Richard, Koenig Gerhard

Subjects: “…γ-secretase…”
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Human Papillomavirus L2 Capsid Protein Stabilizes γ-Secretase during Viral Infection by Mac Crite, Daniel DiMaio

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New Flurbiprofen Derivatives: Synthesis, Membrane Affinity and Evaluation of in Vitro Effect on β-Amyloid Levels by Stephanie Pacella, Lucia Grumetto, Francesco Barbato, Dario Ambrosini, Gianfabio Giorgioni, Hasan Türkez, Antonella Fontana, Ivana Cacciatore, Lisa Marinelli, Piera Sozio, Amelia Cataldi, Antonio Di Stefano

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Inhibition of APP gamma-secretase restores Sonic Hedgehog signaling and neurogenesis in the Ts65Dn mouse model of Down syndrome by Andrea Giacomini, Fiorenza Stagni, Stefania Trazzi, Sandra Guidi, Marco Emili, Elizabeth Brigham, Elisabetta Ciani, Renata Bartesaghi

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Endosome and Lysosome Membrane Properties Functionally Link to γ-Secretase in Live/Intact Cells by Mei C. Q. Houser, Shane P. C. Mitchell, Priyanka Sinha, Brianna Lundin, Oksana Berezovska, Masato Maesako

Subjects: “…γ-secretase…”
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DAPT Attenuates Cadmium-Induced Toxicity in Mice by Inhibiting Inflammation and the Notch/HES-1 Signaling Axis by Jia-Ying Yang, Dan-Yang Shen, Jun Wang, Jing-Feng Dai, Xiao-Yan Qin, Yang Hu, Rongfeng Lan

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Multiple γ-secretase product peptides are coordinately increased in concentration in the cerebrospinal fluid of a subpopulation of sporadic Alzheimer’s disease subjects by Hata Saori, Taniguchi Miyako, Piao Yi, Ikeuchi Takeshi, Fagan Anne M, Holtzman David M, Bateman Randall, Sohrabi Hamid R, Martins Ralph N, Gandy Sam, Urakami Katsuya, Suzuki Toshiharu

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A History of Antidementic Drug Development in Japan by Masatoshi Takeda, Shinji Tagami

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The Genomic Architecture of Hidradenitis Suppurativa—A Systematic Review by Nikolai Paul Pace, Dillon Mintoff, Dillon Mintoff, Isabella Borg, Isabella Borg, Isabella Borg

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Active site geometry stabilization of a presenilin homolog by the lipid bilayer promotes intramembrane proteolysis by Lukas P Feilen, Shu-Yu Chen, Akio Fukumori, Regina Feederle, Martin Zacharias, Harald Steiner

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Role of Jagged1-Hey1 Signal in Angiotensin II-induced Impairment of Myocardial Angiogenesis by Ai-Li Guan, Tao He, Yi-Bing Shao, Yi-Fan Chi, Hong-Yan Dai, Yan Wang, Li Xu, Xuan Yang, Hua-Min Ding, Shang-Lang Cai

Subjects: “…γ-secretase; Angiotensin II; Cardiac Angiogenesis; Hey; Jagged1…”
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