The differential metabolite profiles of acute lymphoblastic leukaemic patients treated with 6-mercaptopurine using untargeted metabolomics approach by Bannur, Zakaria, Teh, Lay Kek, Hennesy, T., Wan Rosli, Wan Rosalina, Mohamad, Norsarwany, Nasir, Ariffin, Ankathil, Ravindran, Zakaria, Zainul Amiruddin, Baba, Aziz, Salleh, Mohd Zaki

“…Methods Metabolomic profile of 21 ALL patients treated with 6-mercaptopurine and 10 healthy volunteers were analysed using liquid chromatography/mass spectrometry quadrupole-time of flight (LC/MS Q-TOF). …”

Hybrid chitosan gold nanoparticles for photothermal therapy and enhanced cytotoxic action of 6-mercaptopurine on breast cancer cell line by Amna H. Faid, Fatma El Zahraa Hussein, Elham M. Mostafa, Samia A. Shouman, Yehia A. Badr, Mahmoud A. Sliem

“…Abstract Background One of the most popular anti-inflammatory and anti-leukemic medications is 6-mercaptopurine, along with its riboside derivatives. …”
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Gold nanoparticles loaded chitosan encapsulate 6-mercaptopurine as a novel nanocomposite for chemo-photothermal therapy on breast cancer by Amna H. Faid, Samia A. Shouman, Yehia A. Badr, Marwa Sharaky, Elham M. Mostafa, Mahmoud A. Sliem

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Results of a phase II clinical trial of 6-mercaptopurine (6MP) and methotrexate in patients with BRCA-defective tumours by Roberts, C, Strauss, VY, Kopijasz, S, Gourley, C, Hall, M, Montes, A, Abraham, J, Clamp, A, Kennedy, R, Banerjee, S, Folkes, LK, Stratford, M, Nicum, S

“…<br><strong>Background: </strong>Tumour cells with BRCA1/2 gene mutations demonstrate increased sensitivity to platinum and poly (ADP-ribose) polymerase (PARP) inhibitors. 6-mercaptopurine (6MP) was found to selectively kill BRCA-defective cells in a xenograft model as effectively as the PARP inhibitor AG014699, even after these cells acquired resistance to a PARP inhibitor or cisplatin.…”

Impact of the homozygous mutation in Nudix hydrolase 15 on myelosuppression with 6-mercaptopurine in a European girl with acute lymphoblastic leukemia: a case report by Laura Elena Pineda-Lancheros, María del Mar Sánchez-Suárez, Luciana María Marangoni-Iglecias, Ricardo García-Fumero, Susana Rojo-Tolosa, Noelia Moreno-Toro

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Promotion of SH-SY5Y Cell Growth by Gold Nanoparticles Modified with 6-Mercaptopurine and a Neuron-Penetrating Peptide by Yaruo Xiao, Enqi Zhang, Ailing Fu

“…Here, we reported a novel application of gold nanoparticles (AuNPs) modified with 6-mercaptopurine (6MP) and a neuron-penetrating peptide (RDP) as a neurophic agent to promote proliferation and neurite growth of human neuroblastoma (SH-SY5Y) cells. …”
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Quantification of 6-Mercaptopurine and Its Metabolites in Patients with Acute Lympoblastic Leukemia Using Dried Blood Spots and UPLC-MS/MS by Supandi Supandi, Yahdiana Harahap, Harmita Harmita, Rizka Andalusia

Subjects: “…6-mercaptopurine…”
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<i>TPMT*3C</i> as a Predictor of 6-Mercaptopurine-Induced Myelotoxicity in Thai Children with Acute Lymphoblastic Leukemia by Thawinee Jantararoungtong, Supaporn Wiwattanakul, Rawiporn Tiyasirichokchai, Santirhat Prommas, Rattanaporn Sukprasong, Napatrupron Koomdee, Pimonpan Jinda, Jiratha Rachanakul, Nutthan Nuntharadthanaphong, Samart Pakakasama, Usanarat Anurathapan, Suradej Hongeng, Chonlaphat Sukasem

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Histidine re-sensitizes pediatric acute lymphoblastic leukemia to 6-mercaptopurine through tetrahydrofolate consumption and SIRT5-mediated desuccinylation by Na Dong, Hui-Xian Ma, Xue-Qin Liu, Dong Li, Ling-Hong Liu, Qing Shi, Xiu-Li Ju

“…Abstract Despite progressive improvements in the survival rate of pediatric B-cell lineage acute lymphoblastic leukemia (B-ALL), chemoresistance-induced disease progression and recurrence still occur with poor prognosis, thus highlighting the urgent need to eradicate drug resistance in B-ALL. The 6-mercaptopurine (6-MP) is the backbone of ALL combination chemotherapy, and resistance to it is crucially related to relapse. …”
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Understanding Adolescent and Young Adult 6-Mercaptopurine Adherence and mHealth Engagement During Cancer Treatment: Protocol for Ecological Momentary Assessment by Alexandra M Psihogios, Mashfiqui Rabbi, Annisa Ahmed, Elise R McKelvey, Yimei Li, Jean-Philippe Laurenceau, Stephen P Hunger, Linda Fleisher, Ahna LH Pai, Lisa A Schwartz, Susan A Murphy, Lamia P Barakat

“…ObjectiveThis protocol aims to determine the temporal associations between daily contextual factors and 6-mercaptopurine (6-MP) adherence and explore the proximal impact of various engagement strategies on ecological momentary assessment survey completion. …”
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Incidence and determinants of hematotoxicity in acute lymphoblastic leukemia children who received 6-mercaptopurine based maintenance therapy in Addis Ababa, Ethiopia by Awol Mekonnen Ali, Haileyesus Adam, Daniel Hailu, Marieke J. H. Coenen, Rawleigh Howe, Teferra Abula

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Erythrocyte-incorporated 6-mercaptopurine metabolite levels are not affected by recent drug administration during maintenance therapy for childhood acute lymphoblastic leukemia by Lauryna Aukstikalne, Ignas Klejus, Maria Thastrup, Tadas Zvirblis, Kjeld Schmiegelow, Goda Elizabeta Vaitkeviciene, Linea Natalie Toksvang

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Incidence and determinants of hematotoxicity in acute lymphoblastic leukemia children who received 6-mercaptopurine based maintenance therapy in Addis Ababa, Ethiopia. by Awol Mekonnen Ali, Haileyesus Adam, Daniel Hailu, Marieke J H Coenen, Rawleigh Howe, Teferra Abula

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A phase II clinical trial of 6-mercaptopurine (6MP) and methotrexate in patients with BRCA defective tumours: a study protocol by Nicum, S, Roberts, C, Boyle, L, Kopijasz, S, Gourley, C, Hall, M, Montes, A, Poole, C, Collins, L, Schuh, A, Dutton, S

“…</p> <p><strong>Methods</strong> This multi-centre phase II single arm trial was designed to investigate the activity and safety of 6-mercaptopurine (6MP) 55 mg/m2 per day, and methotrexate 15 mg/m2 per week in patients with advanced breast or ovarian cancer, ECOG PS 0–2, progressing after ≥ one prior regimen and known to bear a BRCA1/2 germ line mutation. …”

Detection of Hypoxanthine from Inosine and Unusual Hydrolysis of Immunosuppressive Drug Azathioprine through the Formation of a Diruthenium(III) System by Marta Orts-Arroyo, Isabel Castro, José Martínez-Lillo

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Early Initiation of Adalimumab Significantly Diminishes Postoperative Crohn’s Disease Endoscopic Recurrence and Is Superior to 6-Mercaptopurine Therapy: An Open-Label, Randomized Controlled Study by Ayal Hirsch, Erez Scapa, Naomi Fliss-Isakov, Hagit Tulchinsky, Eran Itzkowitz, Yehuda Kariv, Yulia Ron, Henit Yanai, Ian White, Sharief Yassin, Nathaniel Aviv Cohen, Eli Brazovski, Iris Dotan, Nitsan Maharshak

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Adsorption/Desorption Behaviors and SERS Chemical Enhancement of 6-Mercaptopurine on a Nanostructured Gold Surface: The Au₂₀ Cluster Model by Nguyen Thi Nhat Hang, Nguyen Thanh Si, Minh Tho Nguyen, Pham Vu Nhat

Subjects: “…6-mercaptopurine…”
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Genetic variants of genes involved in thiopurine metabolism pathway are associated with 6-mercaptopurine toxicity in pediatric acute lymphoblastic leukemia patients from Ethiopia by Awol Mekonnen Ali, Haileyesus Adam, Daniel Hailu, Ephrem Engidawork, Rawleigh Howe, Teferra Abula, Marieke J. H. Coenen

“…Genetic polymorphisms in enzymes other than TPMT involved in the 6-mercaptopurine pathway should be considered during its use to avoid hematological toxicity.…”
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Folate Receptor-Targeted and GSH-Responsive Carboxymethyl Chitosan Nanoparticles Containing Covalently Entrapped 6-Mercaptopurine for Enhanced Intracellular Drug Delivery in Leukemia by Xuan Wei, Jianhong Liao, Zahra Davoudi, Hua Zheng, Jingru Chen, Dan Li, Xiong Xiong, Yihua Yin, Xiuxiang Yu, Jinghui Xiong, Qun Wang

“…For enhanced intracellular accumulation of 6-mercaptopurine (6-MP) in leukemia, a folate receptor-targeted and glutathione (GSH)-responsive polymeric prodrug nanoparticle was made. …”
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Effect of ITPA Polymorphism on Adverse Drug Reactions of 6-Mercaptopurine in Pediatric Patients with Acute Lymphoblastic Leukemia: A Systematic Review and Meta-Analysis by Yeonhong Lee, Eun Jeong Jang, Ha-Young Yoon, Jeong Yee, Hye-Sun Gwak

Subjects: “…6-mercaptopurine…”
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