The Effect of <i>NUDT15</i>, <i>TPMT</i>, <i>APEX1</i>, and <i>ITPA</i> Genetic Variations on Mercaptopurine Treatment of Pediatric Acute Lymphoblastic Leukemia by Jae Min Lee, Ye Jee Shim, Do-Hoon Kim, Nani Jung, Jung-Sook Ha

Subjects: “…6-mercaptopurine…”
Get full text

Pharmacogenetic Testing for the Pediatric Gastroenterologist: Actionable Drug–Gene Pairs to Know by Tracy Sandritter, Rachel Chevalier, Rebecca Abt, Valentina Shakhnovich

“…Gastroenterologists represent some of the earlier adopters of precision medicine through pharmacogenetic testing by embracing upfront genotyping for thiopurine S-methyltransferase nucleotide diphosphatase (<i>TPMT</i>) before prescribing 6-mercaptopurine or azathioprine for the treatment of inflammatory bowel disease. …”
Get full text

Juvenile Myelomonocytic Leukemia in a Child: A Case Report of Palliative Chemotherapy and Literature Review Applied to Limited Resources Centers by Natharina Yolanda, Stefanus Gunawan, Max F. J. Mantik, Anjo J. P. Veerman

“…The patient was treated with oral 6-mercaptopurine and subcutaneous cytarabine. Four weeks after receiving 6-mercaptopurine, the white blood cell count decreased to 10.6 × 103/μL and the spleen size was half of the original size. …”
Get full text

Curcumin-QingDai Combination as Treatment for Moderate-Severe Ulcerative Colitis by Shomron Ben-Horin, Uri Kopylov, Nir Salomon

“…He partially responded to infliximab but later lost response to an optimized dose of infliximab in combination with 6-mercaptopurine, presenting with worsening symptoms and severe Mayo 3 mucosal inflammation. …”
Get full text

Polymer-Based Nanoparticles as Drug Delivery Systems for Purines of Established Importance in Medicine by Piotr Szyk, Beata Czarczynska-Goslinska, Dariusz T. Mlynarczyk, Barbara Ślusarska, Tomasz Kocki, Marta Ziegler-Borowska, Tomasz Goslinski

“…Moreover, nanocarriers were able to diminish the toxic effects of acyclovir, didanosine, cladribine, tenofovir, 6-mercaptopurine, and 6-thioguanine.…”
Get full text

Robert S. Schwartz, MD, a transformative figure in immunosuppression that revolutionized transplantation by Xian C. Li

“…His seminal studies on 6-mercaptopurine in 1959 gave birth to an entirely new specialty of immunosuppression that dramatically accelerated the advancement of clinical organ transplantation.…”
Get full text

Treatment of acute lymphoblastic leukemia in children: a review of literature by G. A. Aleskerova

“…The article tells about the main stages of improving treatment regimens for acute lymphoblastic leukemia (ALL) in children, from monotherapy with prednisolone and 6-mercaptopurine to novel multicomponent risk-adapted chemotherapy protocols. …”
Get full text

Review: Immunomodulators for all patients with inflammatory bowel disease? by Sandro Ardizzone, Andrea Cassinotti, Gianpiero Manes, Gabriele Bianchi Porro

“…We review the recommended or suggested use of conventional immunomodulators such as azathioprine, 6-mercaptopurine, methotrexate in the treatment of IBD. …”
Get full text

Treatment of Autoimmune Hepatitis by Ja Kyung Kim

“…Although no randomized controlled trials have been performed, MMF, cyclosporine, tacrolimus, 6-mercaptopurine, 6-thioguanine, allopurinol, sirolimus, everolimus, infliximab, or rituximab have been attempted in patients not responding to or intolerant to first-line treatments. …”
Get full text

Oral methotrexate is as effective as intramuscular in maintenance therapy of acute lymphoblastic leukaemia. by Chessells, J, Leiper, A, Tiedemann, K, Hardisty, R, Richards, S

“…One hundred and forty four children with acute lymphoblastic leukaemia not of the T cell type were randomised to receive continuing treatment with daily 6-mercaptopurine, vincristine, and prednisolone six weekly and methotrexate once weekly, either as a single oral dose or an intramuscular injection. …”

Chemo-free maintenance therapy in adult T-cell acute lymphoblastic leukemia: A case report and literature review by Yuanbin Song, Shuzhao Chen, Chenfei Liu, Lezong Chen, Weida Wang, Bingyi Wu, Yang Liang

“…The classic drugs used in the maintenance phase such as 6-mercaptopurine, methotrexate, corticosteroid and vincristine have potentially serious toxicities. …”
Get full text

Novel Thioethers of Dihydroartemisinin Exhibiting Their Biological Activities by Ngoc Hung Truong, Thi Hong Ha Tran, Kim Chi Hoang, Duc Bao Ninh, Viet Duc Le, Duc Anh Le, Van Chinh Luu

“…Analysis of the NMR spectral data indicated that the dimer of DHA with thiols 6-mercaptopurine and 2-mercaptoimidazole was produced with yields of 31% and 62%, respectively. …”
Get full text

Influence of the Photodegradation of Azathioprine on DNA and Cells by Mihaela-Cristina Bunea, Victor-Constantin Diculescu, Monica Enculescu, Daniela Oprea, Teodor Adrian Enache

“…The mechanism of action is based on its biologically active metabolite 6-mercaptopurine (6-MP), which is converted, among others, into thioguanine nucleotides capable of incorporating into replicating DNA, which may act as a strong UV chromophore and trigger DNA oxidation. …”
Get full text

Prognostic importance of myelosuppression during maintenance treatment of lymphoblastic leukaemia. Leukaemia in Childhood Working Party of the Medical Research Council. by Dolan, G, Lilleyman, J, Richards, S

“…Those receiving daily 6-mercaptopurine and weekly methotrexate who were in first remission 20 months from diagnosis were divided into two groups on the basis of whether or not they had ever had an absolute neutrophil count of less than 0.5 x 10(9)/l recorded during maintenance treatment up to that time. …”

In Vivo Genome-Wide Gene Expression Profiling Reveals That Haemophilus influenzae Purine Synthesis Pathway Benefits Its Infectivity within the Airways by Begoña Euba, Celia Gil-Campillo, Javier Asensio-López, Nahikari López-López, Emel Sen-Kilic, Roberto Díez-Martínez, Saioa Burgui, Mariette Barbier, Junkal Garmendia

“…Likewise, the purine analogs 6-thioguanine and 6-mercaptopurine reduced H. influenzae viability in a dose-dependent manner. …”
Get full text

Syntheses of metal oxide-gold nanocomposites for biological applications by Kanika Bharti, Kalyan K. Sadhu

“…Abnormal levels of hydrazine (principal component of various pharmaceutical derivative), Cr(VI), tertracyclin (broad spectrum antibiotic), 6-mercaptopurine (anticancer drug), Bisphenol A (BPA), chlorpyrifos and carbamate pesticides have been estimated with these metal oxide-gold nanocomposites. …”
Get full text

Biomarkers Predictive of Response to Thiopurine Therapy in Inflammatory Bowel Disease by Jack S. Cornish, Elisa Wirthgen, Jan Däbritz, Jan Däbritz

“…In light of multiple recent publications of biomarkers and biological therapy, our focus in this review is predicting response to thiopurine treatment only, that is, Azathioprine and 6-Mercaptopurine.…”
Get full text

Tooth Abnormalities and Their Age-Dependent Occurrence in Leukemia Survivors by Anna Jodłowska, Lidia Postek-Stefańska

“…No relationship was also found between the number of dental abnormalities and the cumulative dose of vincristine, L-asparaginase, methotrexate, cyclophosphamide, cytarabine, and 6-mercaptopurine. The age at the onset of antineoplastic therapy is likely to be the strongest risk factor for toxic injury during tooth development.…”
Get full text

Severe Myelotoxicity Associated with Thiopurine S-Methyltransferase*3A/*3C Polymorphisms in a Patient with Pediatric Leukemia and the Effect of Steroid Therapy by Burcu Fatma Belen, Turkız  Gursel, Nalan Akyurek, Meryem Albayrak, Zühre  Kaya, Ülker  Kocak

“…Mutations in the thiopurine S-methyltransferase (TPMT) gene causing excessive myelosuppression during 6-mercaptopurine (MP) therapy may cause excessive bone marrow toxicity. …”
Get full text

Therapeutic role of methotrexate in pediatric Crohn’s disease by Zlatko Djurić, Ljiljana Šaranac, Ivana Budić, Voja Pavlović, Jelena Djordjević

“…The immunomodulatory drugs used for the maintenance of remission in CD include thiopurines (azathioprine and 6-mercaptopurine) and methotrexate (MTX). Development of hepatosplenic T-cell lymphoma in some patients with inflammatory bowel disease, treated with thiopurines only or in combination with anti-tumor necrosis factor agents, resulted in a growing interest in the therapeutic application of MTX in children suffering from CD. …”
Get full text