Feasibility and efficacy of maintenance chemotherapy following autologous bone marrow transplantation for first remission acute lymphoblastic leukaemia. by Tiley, C, Powles, R, Treleaven, J, Catovsky, D, Milan, S, Teo, C, Catalano, J, Mehta, J, Shields, M, Gupta, P

“…Maintenance chemotherapy was commenced in a total of 26 patients and was tolerated to a median daily dose of 6-mercaptopurine of 40.5 mg/m2 and a median weekly dose of MTX 8.3 mg/m2. …”

Conventional medical management of inflammatory bowel disease. by Burger, D, Travis, S

“…Common mistakes in conventional therapy include overprescription of mesalamine for CD; inappropriate use of steroids (for perianal CD, when there is sepsis, or for maintenance); delayed introduction or underdosing with azathioprine, 6-mercaptopurine, or methotrexate; and failure to consider timely surgery. …”

Managing refractory Crohn's disease: challenges and solutions by Tanida S, Ozeki K, Mizoshita T, Tsukamoto H, Katano T, Kataoka H, Kamiya T, Joh T

“…Conventional therapeutics for moderate-to-severe CD include 5-aminosalicylic acid, corticosteroids, purine analogs, azathioprine, and 6-mercaptopurine. Patients who fail to respond to conventional therapy are treated with tumor necrosis factor (TNF)-α inhibitors such as infliximab and adalimumab, but their efficacy is limited due to primary nonresponse or loss of response. …”
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Symptoms of anxiety and depression associated with steroid efficacy and clinical outcomes in patients with inflammatory bowel disease by Shihao Duan, Yi Yang, Yubin Cao, Pingrun Chen, Chang Liang, Yan Zhang

“…Kaplan–Meier survival analysis and Cox regression model were applied to analyze the relationship between anxiety/depression and IBD-related poor outcomes, which were defined as urgent IBD-related hospitalization, IBD-related surgery, or death.ResultsA total of 325 IBD patients were enrolled, 118 of whom were treated with corticosteroids, 88 with azathioprine/6-mercaptopurine (AZA/6-MP), and 147 with anti-TNF agents. …”
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Systematic review: does concurrent therapy with 5-ASA and immunomodulators in inflammatory bowel disease improve outcomes? by Andrews, J, Travis, S, Gibson, P, Gasche, C

“…METHODS: Systematic review with search terms 'azathioprine, 6-mercaptopurine, thiopurine(s), 5 aminosalicylic acid, mesalazine, inflammatory bowel disease, ulcerative colitis, Crohn's disease, immunosuppressant(s), immunomodulator and methotrexate' in November 2007 to identify clinical trials on concurrent 5-ASA and immunomodulator therapy. …”

Targeting purine metabolism in ovarian cancer by Jingchun Liu, Shasha Hong, Jiang Yang, Xiaoyi Zhang, Ying Wang, Haoyu Wang, Jiaxin Peng, Li Hong

“…We then provide an overview of the application of purine antimetabolites, comprising 6-thioguanine, 6-mercaptopurine, methotrexate, fludarabine and clopidogrel. …”
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Case Report: Multifocal EBV-Associated Diffuse Large B-Cell Lymphoma in a Patient With 6-MP Associated Lymphopenia With TPMT Deficiency by Lara Müller-Scholden, Frank Deinlein, Matthias Eyrich, Paul Gerhardt Schlegel, Verena Wiegering, Matthias Wölfl

“…EBV LPD in other settings is less frequent and etiology and pathogenesis are not completely understood.Case PresentationWe present the case of an 18-year old adolescent suffering from lymphoblastic T-cell lymphoma who developed a life-threatening EBV associated B-cell lymphoma while he was under therapy with 6-MP (6- mercaptopurine). An underlying homozygous TPMT (thiopurine S-methyltransferase) deficiency with subsequent insufficient degradation of 6-MP was identified as contributory for the development of a distinct lymphopenia leading to EBV LPD. …”
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The impact of risk stratification by early bone-marrow response in childhood lymphoblastic leukaemia: results from the United Kingdom Medical Research Council trial ALL97 and ALL97... by Mitchell, C, Payne, J, Wade, R, Vora, A, Kinsey, S, Richards, S, Eden, T

“…The 1997 acute lymphoblastic leukaemia (ALL) trial (ALL97) was a randomised comparison of prednisolone versus dexamethasone and of 6-mercaptopurine versus 6-thioguanine. During the first 2 years of the trial, review of survival data showed the preceding trial, UKALL XI, was no better than its predecessor and that survival for childhood ALL in the UK had not improved in the fashion witnessed by other cooperative treatment groups. …”

Metabolic profiling reveals metabolic features of consolidation therapy in pediatric acute lymphoblastic leukemia by Jinqiu Fu, Aijun Zhang, Qinqin Liu, Dong Li, Xiaoming Wang, Libo Si

“…To understand ALL more deeply, the metabolome in fasting plasma of 27 ALL patients before and after high-dose methotrexate therapies (consolidation therapy) including methotrexate and 6-mercaptopurine (6-MP) was investigated. Plasma metabolites were analyzed using liquid chromatography–tandem mass spectrometry (LC–MS). …”
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Compliance with a protocol for acute lymphoblastic leukemia in childhood by Benigna Maria de Oliveira, Maria Thereza Macedo Valadares, Marcilene Rezende Silva, Marcos Borato Viana

“…METHODS: Main abstracted data were: total duration and reasons for interruption of chemotherapy, prescribed doses of 6-mercaptopurine, and median white blood cell and neutrophil counts during the maintenance phase. …”
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Antineoplastic agents associated with the development of drug-induced pancreatitis by N. A. Arablinskiy, O. D. Ostroumova, A. V. Filippova

“…It is known that the following antitumor drugs are also associated with the development of pancreatitis: 6-mercaptopurine, L-asparaginase, tamoxifen, cisplatin, cytarabine, ifosfamide, paclitaxel, docetaxel, oxaliplatin, capecitabine, periwinkle alkaloids, cytosine, cisplatin, interferon alpha-2b, doxorubicin, tamoxifen, gefitinib, vinorelbine, levamizole, methotrexate, 5-fluorouracil, capecitabine, trans-retinoic acid.…”
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Pharmacokinetic–pharmacodynamic modeling of maintenance therapy for childhood acute lymphoblastic leukemia by Anna Gebhard, Patrick Lilienthal, Markus Metzler, Manfred Rauh, Sebastian Sager, Kjeld Schmiegelow, Linea Natalie Toksvang, Jakob Zierk

“…Abstract In the treatment of childhood acute lymphoblastic leukemia (ALL), current protocols combine initial high-dose multiagent chemotherapy with prolonged oral therapy with 6-mercaptopurine (6MP) and low-dose methotrexate (MTX) maintenance therapy. …”
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Analysis of thiopurine methyltransferase variant alleles in childhood acute lymphoblastic leukaemia. by McLeod, H, Coulthard, S, Thomas, A, Pritchard, S, King, D, Richards, S, Eden, O, Hall, A, Gibson, B

“…The role of 6-mercaptopurine (6MP) in the treatment of childhood acute lymphoblastic leukaemia (ALL) is well established. …”

Utilization of Drugs with Pharmacogenetic Dosing Recommendations in Switzerland: A Descriptive Study Using the Helsana Database by Wittwer NL, Meier CR, Huber CA, Meyer zu Schwabedissen HE, Allemann S, Schneider C

“…Preemptive pharmacogenetic testing is reimbursed by health care insurance for only seven drugs (abacavir, carbamazepine, 6-mercaptopurine, azathioprine, 5-fluorouracil, capecitabine, and irinotecan) although, it is proposed to be a cost-effective approach to personalized medicine. …”
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Purine metabolism regulates Vibrio splendidus persistence associated with protein aggresome formation and intracellular tetracycline efflux by Yanan Li, Yanan Li, Thomas K. Wood, Weiwei Zhang, Chenghua Li, Chenghua Li

“…Inhibition of the purine metabolism pathway by 6-mercaptopurine (6-MP, inhibits ATP production), increased persister cell formation and accompanied with the decreasing intracellular ATP levels and increasing cells with protein aggresome. …”
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Magnetically Actuated Shape Memory Polymers for On-Demand Drug Delivery by Anand Utpal Vakil, Maryam Ramezani, Mary Beth B. Monroe

“…These materials were tested for their shape memory properties (dynamic mechanical analysis), cytocompatibility (3T3 fibroblast viability), and tunable drug delivery rates (UV–VIS to evaluate the release of incorporated doxorubicin, 6-mercaptopurine, and/or rhodamine). All polymer composites had >75% cytocompatibility over 72 h. …”
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Combination of Chlorambucil and Mercaptopurine Show Effective Anti-Cancer Effects in Mice Model by Xu W, Di Y, Chu S, Wang Z, Long H, Pu L, Ma R, Wang Y

“…Chlorambucil (Chl) and 6-mercaptopurine (6MP) are the first-line medicines for chronic lymphocytic leukemia and ovarian cancer. …”
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A Human ABC Transporter ABCC4 Gene SNP (rs11568658, 559 G > T, G187W) Reduces ABCC4-Dependent Drug Resistance by Megumi Tsukamoto, Miho Yamashita, Tsuyoshi Nishi, Hiroshi Nakagawa

“…Both azathioprine and 6-mercaptopurine showed comparable EC50 values against cells expressing ABCC4 (G187W) and those expressing ABCC4 (WT). …”
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Development of anti-cancer and anti-hypertensive nanodelivery systems using magnetite iron oxide-polymeric nanoparticles by Dorniani, Dena

“…This may be attributed to the differences in the percentage of 6-mercaptopurine between the two nanocomposites. Also, MP which is loaded into the surface of FNPs-chitosan compared to FNPs-PEG nanocarrier with the same molar ratio, shows better cytotoxicity effect which is due to the role of chitosan. …”
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The drug-survival of low-dose thioguanine in patients with inflammatory bowel disease: a retrospective observational study by Helena Gensmyr-Singer, Mårten Werner, Pontus Karling

“…Overall, when including all thiopurine attempts, thioguanine had the longest drug-survival [Mantel–Cox rank test: thioguanine versus azathioprine p  = 0.014; thioguanine versus 6-mercaptopurine (6-MP) p  < 0.001]. For second-line thiopurine treatment thioguanine had longer drug-survival than 6-MP (Mantel–Cox rank test: p  = 0.006). …”
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