6-Mercaptopurine Or Azathioprine? by McGovern, D, Travis, S

Cytotoxicity effect of 6-mercaptopurine and 6-mercaptopurine riboside on RAW 264.7 and HIG-82 cell lines by Che Ku Daud, Che Ku Dahlan, Zailani, Muhamad Zulhilmi, Sukiman, Nor Erma Suryana, Tham, Chau Ling, Ahmad, Zuraini, Yong, Yoke Keong, Mohd Zain, Zetty Nadia, Abdullah, Muhammad Nazrul Hakim

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Toxicity evaluation of 6-mercaptopurine-Chitosan nanoparticles in rats by Prem Kumar Govindappa, Darukeshwara Joladarashi, Raghavendra Lakshmana Shetty Hallur, Jagadeesh S. Sanganal, Ayyalasomayajula Ratna Phani

“…Background: The 6-mercaptopurine (6-MP) is an effective immunosuppressant and anti-cancer drug. …”
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Cellular Uptake and Transport Mechanism of 6-Mercaptopurine Nanomedicines for Enhanced Oral Bioavailability by Zou Y, Gao W, Jin H, Mao C, Zhang Y, Wang X, Mei D, Zhao L

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Azathioprine and 6-mercaptopurine-induced intrahepatic cholestasis of pregnancy: Case report and review of the literature by Maya Frank Wolf, Ronen Sloma, Luiza Akria, Eli Rimon, Yifat Wiener, Michal Carmiel Haggai, Lior Lowenstein

“…Objective: Azathioprine, a prodrug of 6-mercaptopurine (6-MP), is used in the treatment of inflammatory bowel disease and may be continued during pregnancy. …”
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Tumor Microenvironment-Responsive 6-Mercaptopurine-Releasing Injectable Hydrogel for Colon Cancer Treatment by Sungjun Kim, Wonjeong Lee, Heewon Park, Kyobum Kim

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Double Hydroxyl Salt as Smart Biocompatible pH-Responsive Carrier for 6-Mercaptopurine by Mariusz Sandomierski, Marcel Jakubowski, Maria Ratajczak, Adam Patalas, Katarzyna Gaweł-Bęben, Paulina Lechwar, Adam Voelkel

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Preparation of 6-Mercaptopurine Loaded Liposomal Formulation for Enhanced Cytotoxic Response in Cancer Cells by Alam Jamal, Amer H. Asseri, Ehab M. M. Ali, Afnan H. El-Gowily, Mohamed Imran Khan, Salman Hosawi, Reem Alsolami, Tarek A. Ahmed

Subjects: “…6-mercaptopurine…”
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Factitious Disorder in Crohn's Disease: Recurrent Pancytopenia Caused by Surreptitious Ingestion of 6-Mercaptopurine by Allon Kahn, Erika S. Boroff, Kari A. Martin, Donald W. Northfelt, Russell I. Heigh

“…We present the case of a patient with Crohn's disease with recurrent pancytopenia attributed to the surreptitious ingestion of 6-mercaptopurine. In patients with possible access to immunomodulatory drugs, a high suspicion for and early identification of factitious disorder may improve patient outcomes and avoid invasive and costly diagnostic evaluations.…”
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Antiviral Potential of Azathioprine and Its Derivative 6- Mercaptopurine: A Narrative Literature Review by Carolina Rios-Usuga, Marlen Martinez-Gutierrez, Julian Ruiz-Saenz

“…The use of azathioprine (AZA) in human medicine dates back to research conducted in 1975 that led to the development of several drugs, including 6-mercaptopurine. In 1958, it was shown that 6-mercaptopurine decreased the production of antibodies against earlier administered antigens, raising the hypothesis of an immunomodulatory effect. …”
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Preparation and characterization of 6-mercaptopurine-coated magnetite nanoparticles as a drug delivery system by Dorniani, Dena, Hussein, Mohd. Zobir, Kura, Aminu Umar, Fakurazi, Sharida, Shaari, Abdul Halim, Ahmad, Zalinah

“…The release of 6-mercaptopurine from the FCMP nanocomposite was found to be sustained and governed by pseudo-second order kinetics. …”
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Inhibition of Xanthine Oxidase-Catalyzed Xanthine and 6-Mercaptopurine Oxidation by Flavonoid Aglycones and Some of Their Conjugates by Violetta Mohos, Eszter Fliszár-Nyúl, Miklós Poór

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Effect of maintenance therapy for childhood with acute lymphoblastic leukaemia by combination of methotrexate and 6–mercaptopurine on the liver. by Abid T. Firas, Al–Fakhri F. Ilham

“… Seven of 30 children with acute lymphoblastic leukaemia (ALL) receiving maintenance therapy (MT) consisting of daily oral 6–mercaptopurine (6MP) and weekly methotrexate (MTX) developed both hepatocellular destruction and intrahepatic cholestasis (with abnormally elevated levels of serum aminotransferases enzymes GOT, GPT that mainly indicate liver cell destruction, and alkaline phosphatase, gammaglutamyl transferase enzymes, as well as total serum bilirubin that mainly indicate biliary tract disorder). …”
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Anti-arthritic effects of 6-mercaptopurine and its derivatives in arthritis-induced model, In vitro and In vivo by Che Ku Daud, Che Ku Dahlan

“…In this study, four thiopurine compounds namely, 6- mercaptopurine (6-MP), 6-MP riboside, 6-thioguanine (6-TG) and 6-thioxanthine (6- TX) with diclofenac (a non-steroidal anti-inflammatory drug; NSAID) as positive control were screened for their cytotoxicity and anti-inflammatory properties by evaluating the cell cytotoxicity and the nitric oxide (NO) inhibitory activities upon activated fibroblast synoviocytes (HIG-82) and macrophage (RAW 264.7) cell lines with phorbol-12- myristate acetate (PMA) and lipopolysaccharide (LPS), respectively. …”
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Improved HPLC Quantification of 6-Mercaptopurine Metabolites in Red Blood Cells: Monitoring Data and Literature Analysis by Tiphaine Adam de Beaumais, Yves Medard, Océane Amblard, Lauriane Goldwirt, Mathieu Simonin, Christine Martinez Vinson, Arnaud Petit, Evelyne Jacqz-Aigrain

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6-Mercaptopurine-induced fever in a case of B-acute lymphoblastic leukemia: A case report by Saroj Bala, Amit Kumar, Prasad Dange, Yashwant Kashyap, Avinash Tiwari

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Toxicity and efficacy of 6-thioguanine versus 6-mercaptopurine in childhood lymphoblastic leukaemia: a randomised trial. by Vora, A, Mitchell, C, Lennard, L, Eden, T, Kinsey, SE, Lilleyman, J, Richards, S

“…BACKGROUND: 6-mercaptopurine has been a standard component of long-term continuing treatment for childhood lymphoblastic leukaemia, whereas 6-thioguanine has been mainly used for intensification courses. …”

Inhibition of xanthine oxidase-catalyzed xanthine and 6-mercaptopurine oxidation by luteolin, naringenin, myricetin, ampelopsin and their conjugated metabolites by Orsolya Balázs, Ágnes Dombi, Balázs Z. Zsidó, Csaba Hetényi, Kateřina Valentová, Róbert G. Vida, Miklós Poór

“…In this study, we examined the impacts of luteolin, naringenin, myricetin, ampelopsin, and their sulfate/glucuronide derivatives on XO-catalyzed xanthine and 6-mercaptopurine oxidations employing in vitro enzyme incubation assays and molecular modeling studies. …”
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Exploring the Enhanced Antiproliferative Activity of Turmeric Oil and 6-Mercaptopurine in a Combined Nano-Particulate System Formulation by Tarek A. Ahmed, Ehab M. M. Ali, Abdulaziz A. Kalantan, Alshaimaa M. Almehmady, Khalid M. El-Say

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Profound Hypoglycemia and High Anion Gap Metabolic Acidosis in a Pediatric Leukemic Patient Receiving 6-Mercaptopurine by Molly O’Shea, Alexis Kuhn, Ana L. Creo, Mira Kohorst, Asmaa Ferdjallah

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