WT1 Trio Peptide-Based Cancer Vaccine for Rare Cancers Expressing Shared Target WT1 by Yusuke Oji, Naoki Kagawa, Hideyuki Arita, Norifumi Naka, Ken-ichiro Hamada, Hidetatsu Outani, Yasushi Shintani, Yoshito Takeda, Eiichi Morii, Kenzo Shimazu, Motoyuki Suzuki, Sumiyuki Nishida, Jun Nakata, Akihiro Tsuboi, Miki Iwai, Sae Hayashi, Rin Imanishi, Sayaka Ikejima, Mizuki Kanegae, Masahiro Iwamoto, Mayu Ikeda, Kento Yagi, Haruka Shimokado, Hiroko Nakajima, Kana Hasegawa, Soyoko Morimoto, Fumihiro Fujiki, Akira Nagahara, Atsushi Tanemura, Yutaka Ueda, Tsunekazu Mizushima, Masato Ohmi, Takayuki Ishida, Manabu Fujimoto, Norio Nonomura, Tadashi Kimura, Hidenori Inohara, Seiji Okada, Haruhiko Kishima, Naoki Hosen, Atsushi Kumanogoh, Yoshihiro Oka, Haruo Sugiyama

“…The recruitment criteria included WT1-expressing tumors as well as HLA-A*24:02 or 02:01. The primary endpoints were immunoglobulin G (IgG) antibody (Ab) production against the WT1-235 cytotoxic T lymphocyte (CTL) epitope and delayed-type hypersensitivity (DTH) skin reactions to targeted WT1 CTL epitopes. …”
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Instrumento para evaluar la adherencia a tratamientos en pacientes con factores de riesgo cardiovascular Instrumento para avaliar a aderência a tratamentos em pacientes com fatores... by CONSUELO ORTIZ SUÁREZ

“…Los resultados del estudio mostraron que la validez de constructo realizada al instrumento permitió reducir el número de ítems de 53 a 24 a través del análisis factorial, sin afectar las 4 dimensiones del instrumento; el índice de consistencia interna por medio del método del alfa de Cronbach fue de 0,60, lo cual se considera adecuado. …”
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Гігієнічна оцінка біологічної контамінації поверхневих водойм Українського Придунав’я = Hygienic assessment of Ukrainian Danube region surface water bodies biological contamination... by L. I. Kovalchuk, V. A. Korobchansky, A. V. Mokienko

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Топінг як явище в Українських реаліях: очевидні помилки під час його виконання та їх шкідливі наслідки для зелених насаджень... by M. Yu. Osipov, Yu. A. Velychko, S. A. Maslovata, N. L. Palivoda

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Efficacy of Front-Line Ibrutinib and Rituximab Combination and the Impact of Treatment Discontinuation in Unfit Patients with Chronic Lymphocytic Leukemia: Results of the Gimema LL... by Francesca Romana Mauro, Francesca Paoloni, Stefano Molica, Gianluigi Reda, Livio Trentin, Paolo Sportoletti, Monia Marchetti, Daniela Pietrasanta, Roberto Marasca, Gianluca Gaidano, Marta Coscia, Caterina Stelitano, Donato Mannina, Nicola Di Renzo, Fiorella Ilariucci, Anna Marina Liberati, Lorella Orsucci, Francesca Re, Monica Tani, Gerardo Musuraca, Daniela Gottardi, Pier Luigi Zinzani, Alessandro Gozzetti, Annalia Molinari, Massimo Gentile, Annalisa Chiarenza, Luca Laurenti, Marzia Varettoni, Adalberto Ibatici, Roberta Murru, Valeria Ruocco, Ilaria Del Giudice, Maria Stefania De Propris, Irene Della Starza, Sara Raponi, Mauro Nanni, Paola Fazi, Antonino Neri, Anna Guarini, Gian Matteo Rigolin, Alfonso Piciocchi, Antonio Cuneo, Robin Foà

“…Patients who discontinued ibrutinib due to an AE showed a 24-month next treatment-free survival rate of 63%. …”
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Problematyka prywatności przy udzielaniu świadczeń zdrowotnych osobom starszym – wybrane aspekty prawne = Privacy issues in the provision of health services for the elderly – selec... by Iwona Wrześniewska-Wal, Anna Augustynowicz, Aleksandra Czerw

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Intervenção educacional em equipes do Programa de Saúde da Família para promoção da amamentação Intervención educacional en equipos del Programa de Salud de la Familia para la prom... by Antônio Prates Caldeira, Gizele Carmem Fagundes, Gabriel Nobre de Aguiar

“…The teams randomly selected into intervention and control group, and the intervention group took part in a 24-hour training program on breastfeeding promotion for health providers, modeled on the Baby-Friendly Hospital Initiative. …”
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Methods for Simultaneous Evaluation of Productivity, Adaptability and Genotypic Stability in Eucalyptus grandis Progeny Trials in the State of Sao Paulo Avaliação Simultânea de Pro... by José Elidney Pinto Júnior, José Alfredo Sturion, Marcos Deon Vilela de Resende, Pedro Ronzelli Júnior

“…A adoção de estratégias e critérios propostos para seleção permitirá compor uma população selecionada com duzentos indivíduos de maiores valores genéticos, com número efetivo de progênies adequado, propiciando ganhos para DAP de 12,89 % a 24,33 %, em relação à média, no estabelecimento de um pomar de sementes por mudas. …”
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Global wetland contribution to 2000–2012 atmospheric methane growth rate dynamics by Benjamin Poulter, Philippe Bousquet, Josep G Canadell, Philippe Ciais, Anna Peregon, Marielle Saunois, Vivek K Arora, David J Beerling, Victor Brovkin, Chris D Jones, Fortunat Joos, Nicola Gedney, Akihito Ito, Thomas Kleinen, Charles D Koven, Kyle McDonald, Joe R Melton, Changhui Peng, Shushi Peng, Catherine Prigent, Ronny Schroeder, William J Riley, Makoto Saito, Renato Spahni, Hanqin Tian, Lyla Taylor, Nicolas Viovy, David Wilton, Andy Wiltshire, Xiyan Xu, Bowen Zhang, Zhen Zhang, Qiuan Zhu

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Cobertura vacinal em menores de dois anos a partir de registro informatizado de imunização em Curitiba, PR Cobertura vacunal en menores de dos años a partir de registro informatiza... by Karin Regina Luhm, Maria Regina Alves Cardoso, Eliseu Alves Waldman

“…<br>OBJETIVO: Evaluar el programa de inmunización de niños de 12 a 24 meses de edad con base en el registro informatizado de inmunización. …”
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Randomised controlled trial and economic analysis of an internet-based weight management programme: POWeR+ (Positive Online Weight Reduction) by Paul Little, Beth Stuart, FD Richard Hobbs, Jo Kelly, Emily R Smith, Katherine J Bradbury, Stephanie Hughes, Peter WF Smith, Michael V Moore, Mike EJ Lean, Barrie M Margetts, Christopher D Byrne, Simon Griffin, Mina Davoudianfar, Julie Hooper, Guiqing Yao, Shihua Zhu, James Raftery, Lucy Yardley

“…Interventions: Positive Online Weight Reduction (POWeR+) is a 24-session, web-based weight management intervention completed over 6 months. …”
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Medical Tourism and the Libyan National Health Services by El Taguri A

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Generation of a GDE heterozygous mutation human embryonic stem cell line WAe001-A-14 by CRISPR/Cas9 editing by Guosheng Xu, Dongsheng Guo, Feima Wu, Nasir Abbas, Keyu Lai, Fang Yuan, Kai You, Yanli Liu, Yuanqi Zhuang, Yuhang Wu, Yingying Xu, Yan Chen, Fan Yang, Tingcai Pan, Yin-xiong Li

“…This cell line contains a 24-nucleotide deletion within exon-13 of GDE, resulting in 8 amino acids (TRLGISSL) missing of the GDE protein from amino acid position 567 to 575. …”
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Kıyas Şekillerinin Geometrik Yöntemle İrcâ‘ı by Ekrem Sefa Gül

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Avaliação dos impactos dos processos de inclusão digital e informacional nos usuários de programas e projetos no Brasil by Benedito Medeiros Neto

“…Quanto à localização e acesso da informação pelo usuário, os sites de relacionamentos e mensageiros eletrônicos tiveram maior procura pelos mais jovens, sendo que 64% dos usuários estavam na faixa etária de 16 a 24 anos. Interesse em desenvolver trabalhos escolares foi referido por 65% dos usuários, em todas as faixas etárias, com comportamento semelhante nos diferentes graus de instrução. …”
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Regulation of Th2 responses by Lactococcus lactis subsp. cremoris YRC3780 alleviates DNCB-induced atopic dermatitis in the mouse model by Rong Wang, Haruyo Nakajima-Adachi, Yimei Wang, Yingyu Zhou, Wenting Gu, Erika Hiraide, Mamiko Morinaga, Ryogo Nakagawa, Shotaro Nakamura, Tomohiro Takano, Xuyang Li, Mayumi Saeki, Osamu Kaminuma, Takachika Hiroi, Kenji Uchida, Hidemasa Motoshima, Masaru Tanokura, Takuya Miyakawa, Satoshi Hachimura

“…The mechanisms by which L. cremoris YRC3780 affects the Th1/Th2 balance in mice were investigated in vitro, focusing on the intestinal immune response. Simultaneously, a 2,4-dinitrochlorobenzene-induced atopic dermatitis mouse model was used to evaluate the symptom improvement effect of oral administration of L. cremoris YRC3780. …”
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Reproductive and morphometric traits of Macrobrachium amazonicum (Decapoda: Palaemonidae) from the Pantanal, Brazil, suggests initial speciation by Liliam Hayd, Klaus Anger

“…This may be due in part to a 2.4-fold increase in egg volume occurring during the course of embryonic development, while the available space under the abdomen remains limited. …”
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Chronic use of hydroxychloroquine did not protect against COVID-19 in a large cohort of patients with rheumatic diseases in Brazil by Gecilmara Salviato Pileggi, Gilda Aparecida Ferreira, Ana Paula Monteiro Gomides Reis, Edgard Torres Reis-Neto, Mirhelen Mendes Abreu, Cleandro Pires Albuquerque, Nafice Costa Araújo, Ana Beatriz Bacchiega, Dante Valdetaro Bianchi, Blanca Bica, Eloisa Duarte Bonfa, Eduardo Ferreira Borba, Danielle Christinne Soares Egypto Brito, Ângela Luzia Branco Pinto Duarte, Rafaela Cavalheiro Espírito Santo, Paula Reale Fernandes, Mariana Peixoto Guimarães, Kirla Wagner Poti Gomes, Adriana Maria Kakehasi, Evandro Mendes Klumb, Cristina Costa Duarte Lanna, Claudia Diniz Lopes Marques, Odirlei André Monticielo, Licia Maria Henrique Mota, Gabriela Araújo Munhoz, Eduardo Santos Paiva, Helena Lucia Alves Pereira, José Roberto Provenza, Sandra Lucia Euzébio Ribeiro, Laurindo Ferreira Rocha Junior, Camila Santana Justo Cintra Sampaio, Vanderson Souza Sampaio, Emília Inoue Sato, Thelma Skare, Viviane Angelina de Souza, Valeria Valim, Marcus Vinícius Guimarães Lacerda, Ricardo Machado Xavier, Marcelo Medeiros Pinheiro

“…Methods This baseline cross-sectional analysis is part of a 24-week observational multi-center study involving 22 Brazilian academic outpatient centers. …”
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RSL3 Drives Ferroptosis Through GPX4 Inactivation and ROS Production in Colorectal Cancer by Xinbing Sui, Xinbing Sui, Xinbing Sui, Ruonan Zhang, Ruonan Zhang, Ruonan Zhang, Shuiping Liu, Shuiping Liu, Shuiping Liu, Ting Duan, Ting Duan, Ting Duan, Lijuan Zhai, Lijuan Zhai, Lijuan Zhai, Mingming Zhang, Mingming Zhang, Mingming Zhang, Xuemeng Han, Xuemeng Han, Xuemeng Han, Yu Xiang, Yu Xiang, Yu Xiang, Xingxing Huang, Haoming Lin, Tian Xie, Tian Xie, Tian Xie

“…Here, we showed that ferroptosis inducer RSL3 initiated cell death and ROS accumulation in HCT116, LoVo, and HT29 CRC cells over a 24 h time course. Furthermore, we found that ROS levels and transferrin expression were elevated in CRC cells treated with RSL3 accompanied by a decrease in the expression of glutathione peroxidase 4 (GPX4), indicating an iron-dependent cell death, ferroptosis. …”
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Avaliação prospectiva dos resultados a longo prazo da terapia intradiscal percutânea lombar por radiofrequência Evaluación prospectiva de resultados a largo plazo de la terapia int... by Daniel Ferreira Ghedini, Rogério Lúcio Chaves de Resende, Túlio Vinícius de Oliveira Campos, Jefferson Soares Leal, Otávio de Lucca Druda, Marco Antônio Percope de Andrade

“…CONCLUSION: IDET technique has proved to be a good alternative in the palliative control of pain and functional incapacity during a 24-month period. Good results have deteriorated after 48 months, with a tendency to return of symptoms as they were prior to treatment.…”
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