THREE STATE MARKOV MODEL: COMPARING THREE PARAMETERIZATIONS OF THE TRANSITION INTENSITY RATE. APPLICATION TO RHEUMATOID ARTHRITIS DATA MODELO DE MARKOV DE TRES ESTADOS: COMPARACIÓN... by Salazar Juan Carlos, Palomino René Iral, Calvo Enrique, Rojas Adriana, Hincapié María Eugenia, Anaya Juan Manuel, Díaz Francisco Javier

“…The method to estimate the effect of the parameters is based on the likelihood function which can be optimized using the exact solutions of a Kolmogorov forward differential equations system in conjunction with the Newton-Raphson algorithm (Abramowitz & Stegun 1972). We use the relative bias to select the best estimation estrategy. …”
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