Targeting autocrine HB-EGF signaling with specific ADAM12 inhibition using recombinant ADAM12 prodomain by Miller, Miles Aaron, Moss, Marcia L., Powell, Gary, Petrovich, Robert, Edwards, Lori, Griffith, Linda G., Lauffenburger, Douglas A., Meyer, Aaron Samuel

“…We designed a specific inhibitor of ADAM12 based on its recombinant prodomain (PA12), which selectively inhibits ADAM12 but not ADAM10 or ADAM17. …”
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microRNA‐29a Regulates ADAM12 Through Direct Interaction With ADAM12 mRNA and Modulates Postischemic Perfusion Recovery by Victor Lamin, Joseph Verry, Olumayowa S. Dokun, Ana Kronemberger, Thomas Wong, Vitor A. Lira, Ayotunde O. Dokun

Subjects: “…ADAM12…”
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Catalytic properties of ADAM12 and its domain deletion mutants. by Jacobsen, J, Visse, R, Sørensen, H, Enghild, J, Brew, K, Wewer, U, Nagase, H

“…ADAM12 exists as two splice variants: a classical type 1 membrane-anchored form (ADAM12-L) and a secreted splice variant (ADAM12-S) consisting of pro, catalytic, disintegrin, cysteine-rich, and EGF domains. …”

The association between ADAM12 gene polymorphisms and osteoarthritis: an updated meta-analysis by Su Yang, Yue-peng Wang, Xi-yong Li, Peng-yong Han, Peng-fei Han

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Correction: The association between ADAM12 gene polymorphisms and osteoarthritis: an updated meta-analysis by Su Yang, Yue-peng Wang, Xi-yong Li, Peng-yong Han, Peng-fei Han

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Analysis of ADAM12-Mediated Ephrin-A1 Cleavage and Its Biological Functions by Katsuaki Ieguchi, Takeshi Tomita, Toshifumi Takao, Tsutomu Omori, Taishi Mishima, Isao Shimizu, Massimiliano Tognolini, Alessio Lodola, Takuya Tsunoda, Shinichi Kobayashi, Satoshi Wada, Yoshiro Maru

“…We previously reported that ADAM12-cleaved ephrin-A1 enhanced lung vascular permeability and thereby induced lung metastasis. …”
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Genetic effects of rs3740199 polymorphism in ADAM12 gene on knee osteoarthritis: a meta-analysis by Zheng Hao, Xin Li, Jin Dai, Baocheng Zhao, Qing Jiang

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Selective inhibition of ADAM12 catalytic activity through engineering of tissue inhibitor of metalloproteinase 2 (TIMP-2). by Kveiborg, M, Jacobsen, J, Lee, M, Nagase, H, Wewer, U, Murphy, G

“…The disintegrin and metalloprotease ADAM12 has important functions in normal physiology as well as in diseases, such as cancer. …”

Alternatively Spliced Isoforms of <i>MUC4</i> and <i>ADAM12</i> as Biomarkers for Colorectal Cancer Metastasis by Saleh Althenayyan, Mohammed H. AlMuhanna, Abdulkareem AlAbdulrahman, Bandar Alghanem, Suliman A. Alsagaby, Abdulaziz Alfahed, Glowi Alasiri, Mohammad Azhar Aziz

“…Hence, we utilized our prior data from an exon microarray and found <i>ADAM12</i> and <i>MUC4</i> to be strong biomarker candidates based on their alternative splicing scores and pattern. …”
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A Disintegrin and Metalloprotease 12 Promotes Tumor Progression by Inhibiting Apoptosis in Human Colorectal Cancer by Young-Lan Park, Sun-Young Park, Hyung-Hoon Oh, Min-Woo Chung, Ji-Yun Hong, Ki-Hyun Kim, Dae-Seong Myung, Sung-Bum Cho, Wan-Sik Lee, Hyun-Soo Kim, Young-Eun Joo

Subjects: “…ADAM12…”
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ADAM12 promotes clear cell renal cell carcinoma progression and triggers EMT via EGFR/ERK signaling pathway by Jinming Xu, Yan Wang, Jiahao Jiang, Cong Yin, Bentao Shi

Subjects: “…ADAM12…”
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Compensation for dystrophin-deficiency: ADAM12 overexpression in skeletal muscle results in increased alpha 7 integrin, utrophin and associated glycoproteins. by Moghadaszadeh, B, Albrechtsen, R, Guo, LT, Zaik, M, Kawaguchi, N, Borup, R, Kronqvist, P, Schroder, H, Davies, K, Voit, T, Nielsen, F, Engvall, E, Wewer, U

“…We then analyzed changes in gene-expression profiles in mdx/ADAM12 transgenic mice compared with their littermate controls and found only a few genes with an expression change greater than 2-fold between mdx/ADAM12 and mdx. …”

ADAM12 abrogation alters immune cell infiltration and improves response to checkpoint blockade therapy in the T11 murine model of triple-negative breast cancer by Guanpeng Wang, Yeni Romero, Indhujah Thevarajan, Anna Zolkiewska

“…The role of cancer cell-expressed ADAM12 in modulating the immune TME is not known. …”
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RETRACTED: The Role of LINC00284 in the Development of Thyroid Cancer via Its Regulation of the MicroRNA-30d-5p-Mediated ADAM12/Notch Axis by Chunmei Hu, Zhichen Kang, Lixin Guo, Fuling Qu, Rongfeng Qu

“…Collectively, our findings indicate that LINC00284 competitively binds to miR-30d-5p and activates the ADAM12-dependent Notch signaling pathway, thereby promoting the development of thyroid cancer.…”
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Retraction: The role of LINC00284 in the development of thyroid cancer via its regulation of the microRNA-30d-5p-mediated ADAM12/Notch axis by Frontiers Editorial Office

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ADAR2 Protein Is Associated with Overall Survival in GBM Patients and Its Decrease Triggers the Anchorage-Independent Cell Growth Signature by Valeriana Cesarini, Domenico Alessandro Silvestris, Federica Galeano, Valentina Tassinari, Maurizio Martini, Franco Locatelli, Angela Gallo

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Modulation of miR-29a and ADAM12 Reduces Post-Ischemic Skeletal Muscle Injury and Improves Perfusion Recovery and Skeletal Muscle Function in a Mouse Model of Type 2 Diabetes and Peripheral Artery Disease by Victor Lamin, Joseph Verry, Isaac Eigner-Bybee, Jordan D. Fuqua, Thomas Wong, Vitor A. Lira, Ayotunde O. Dokun

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Longitudinal Proteomic Analysis of Plasma across Healthy Pregnancies Reveals Indicators of Gestational Age by Elizabeth Yohannes, Danielle L. Ippolito, Jennifer R. Damicis, Elisabeth M. Dornisch, Katherine M. Leonard, Peter G. Napolitano, Nicholas Ieronimakis

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PRDM16 deficiency in vascular smooth muscle cells aggravates abdominal aortic aneurysm by Zhenguo Wang, Xiangjie Zhao, Guizhen Zhao, Yanhong Guo, Haocheng Lu, Wenjuan Mu, Juan Zhong, Minerva Garcia-Barrio, Jifeng Zhang, Y. Eugene Chen, Lin Chang

“…Adam12 knockdown reversed VSMC apoptosis induced by Prdm16 deficiency. …”
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Identification of prognostic gene signature associated with microenvironment of lung adenocarcinoma by Cheng Yue, Hongtao Ma, Yubai Zhou

“…Finally, a three-gene (ADAM12, Bruton Tyrosine Kinase (BTK), ERG) signature was constructed, and ADAM12, BTK can be used as independent prognostic factors. …”
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