Clinical Utility of ¹⁸Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (¹⁸F-FDG PET/CT) in Multivisceral Transplant Patients by Shao Jin Ong, Lisa M. Sharkey, Kai En Low, Heok K. Cheow, Andrew J. Butler, John R. Buscombe

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Reducing global health inequalities for a rare disorder: evaluating the international Prader–Willi Syndrome Organisation’s Echo® programme by Tanzil Rujeedawa, Nora McNairney, Shelly Cordner, James O’Brien, Georgina Loughnan, Anthony Holland

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Functional brain imaging interventions for radiation therapy planning in patients with glioblastoma: a systematic review by John T Ryan, Masao Nakayama, Ian Gleeson, Liam Mannion, Moshi Geso, Jennifer Kelly, Sweet Ping Ng, Nicholas Hardcastle

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Comparison of obstetric anal sphincter injuries in nulliparous women before and after introduction of the EPISCISSORS-60® at two hospitals in the United Kingdom by van Roon Y, Kirwin C, Rahman N, Vinayakarao L, Melson L, Kester N, Pathak S, Pradhan A

“…Yves van Roon,1 Ciara Kirwin,2 Nadia Rahman,3 Latha Vinayakarao,2 Louise Melson,2 Nikki Kester,1 Sangeeta Pathak,1 Ashish Pradhan1 1Department of Obstetrics and Gynecology, Hinchingbrooke Hospital, Huntingdon, 2Department of Obstetrics and Gynecology, Poole Hospital, Poole, 3Department of Obstetrics and Gynecology, Addenbrookes Hospital, Cambridge, UK Aim: To assess whether the introduction of episiotomy scissors specially designed to achieve a cutting angle of 60°, EPISCISSORS-60®, in two hospitals in the UK would result in a reduction in obstetric anal sphincter injuries (OASIS) in nulliparous women.Methods: A structured training program for all doctors and midwives provided a theoretical framework around OASIS including risk factors and the role of episiotomies and a practical hands-on training element to use EPISCISSORS-60® correctly and to measure perineal body length and post-suturing angles. …”
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Beyond N Staging in Breast Cancer: Importance of MRI and Ultrasound-based Imaging by Valerio Di Paola, Giorgio Mazzotta, Vincenza Pignatelli, Enida Bufi, Anna D’Angelo, Marco Conti, Camilla Panico, Vincenzo Fiorentino, Francesco Pierconti, Fleur Kilburn-Toppin, Paolo Belli, Riccardo Manfredi

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Impaired Iron Homeostasis and Haematopoiesis Impacts Inflammation in the Ageing Process in Down Syndrome Dementia by Ruma Raha-Chowdhury, Animesh Alexander Raha, James Henderson, Seyedeh Deniz Ghaffari, Monika Grigorova, Jessica Beresford-Webb, Kieren Allinson, Subhojit Chakraborty, Anthony Holland, Shahid H. Zaman

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Consensus statement from the first RdRp Summit: advancing RNA virus discovery at scale across communities by Justine Charon, Ingrida Olendraite, Marco Forgia, Li Chuin Chong, Luke S. Hillary, Simon Roux, Anne Kupczok, Humberto Debat, Humberto Debat, Shoichi Sakaguchi, Rachid Tahzima, Rachid Tahzima, So Nakagawa, Artem Babaian, Artem Babaian, Aare Abroi, Nicolas Bejerman, Nicolas Bejerman, Karima Ben Mansour, Karima Ben Mansour, Katherine Brown, Anamarija Butkovic, Amelia Cervera, Florian Charriat, Guowei Chen, Yuto Chiba, Yuto Chiba, Lander De Coninck, Tatiana Demina, Guillermo Dominguez-Huerta, Jeremy Dubrulle, Serafin Gutierrez, Serafin Gutierrez, Erin Harvey, Fhilmar Raj Jayaraj Mallika, Dimitris Karapliafis, Shen Jean Lim, Sunitha Manjari Kasibhatla, Sunitha Manjari Kasibhatla, Jonathon C. O. Mifsud, Yosuke Nishimura, Ayda Susana Ortiz-Baez, Milica Raco, Ricardo Rivero, Sabrina Sadiq, Shahram Saghaei, James Emmanuel San, James Emmanuel San, Hisham Mohammed Shaikh, Hisham Mohammed Shaikh, Ella Tali Sieradzki, Matthew B. Sullivan, Yanni Sun, Michelle Wille, Yuri I. Wolf, Nikita Zrelovs, Uri Neri

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Evaluation of PSA and PSA Density in a Multiparametric Magnetic Resonance Imaging-Directed Diagnostic Pathway for Suspected Prostate Cancer: The INNOVATE Trial by Hayley Pye, Saurabh Singh, Joseph M. Norris, Lina M. Carmona Echeverria, Vasilis Stavrinides, Alistair Grey, Eoin Dinneen, Elly Pilavachi, Joey Clemente, Susan Heavey, Urszula Stopka-Farooqui, Benjamin S. Simpson, Elisenda Bonet-Carne, Dominic Patel, Peter Barker, Keith Burling, Nicola Stevens, Tony Ng, Eleftheria Panagiotaki, David Hawkes, Daniel C. Alexander, Manuel Rodriguez-Justo, Aiman Haider, Alex Freeman, Alex Kirkham, David Atkinson, Clare Allen, Greg Shaw, Teresita Beeston, Mrishta Brizmohun Appayya, Arash Latifoltojar, Edward W. Johnston, Mark Emberton, Caroline M. Moore, Hashim U. Ahmed, Shonit Punwani, Hayley C. Whitaker

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Reduced CD27−IgD− B Cells in Blood and Raised CD27−IgD− B Cells in Gut-Associated Lymphoid Tissue in Inflammatory Bowel Disease by Chathyan Pararasa, Na Zhang, Na Zhang, Thomas J. Tull, Ming H. A. Chong, Jacqueline H. Y. Siu, William Guesdon, Konstantia Maria Chavele, Jeremy D. Sanderson, Louise Langmead, Klaartje Kok, Jo Spencer, Anna Vossenkamper

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Doing research in non-specialist mental health services for children and young people: lessons learnt from a process evaluation of the ICALM (Interpersonal Counselling for Adolesce... by Thando Katangwe-Chigamba, Jamie Murdoch, Paul Wilkinson, Viktoria Cestaro, Carys Seeley, Eirini Charami-Roupa, Tim Clarke, Aoife Dunne, Brioney Gee, Sharon Jarrett, Andrew Laphan, Susie McIvor, Richard Meiser-Stedman, Thomas Rhodes, Lee Shepstone, David A. Turner, Jon Wilson

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SMAD3 mutation in LDS3 causes bone fragility by impairing the TGF-β pathway and enhancing osteoclastogenesis by Ahmed El-Gazzar, Heeseog Kang, Nadja Fratzl-Zelman, Emma Webb, Aileen M. Barnes, Milena Jovanovic, Sarju G. Mehta, Vipan Datta, Vrinda Saraff, Ryan K. Dale, Frank Rauch, Joan C. Marini, Wolfgang Högler

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Evaluating pharmacological THRomboprophylaxis in Individuals undergoing superficial endoVEnous treatment across NHS and private clinics in the UK: a multi-centre, assessor-blind, r... by John Norrie, Rebecca Lawton, Joseph Shalhoub, Beverley J Hunt, Annya Stephens-Boal, Tamara Everington, Joanne Dunbar, Sarah Onida, Layla Bolton, Manjit Gohel, A H Davies, Laura Burgess, Matthew Machin, Steven Rogers, Sarah Whittley, Sandip Nandhra, Daniel Carradice, Benedict Turner, Mark S Whiteley, Carolyn Singer

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PARC: a phase I/II study evaluating the safety and activity of pegylated recombinant human arginase BCT-100 in relapsed/refractory cancers of children and young adults by Nicola Fenwick, Rebekah Weston, Keith Wheatley, Jodie Hodgson, Lynley Marshall, Martin Elliott, Guy Makin, Antony Ng, Bernadette Brennan, Stephen Lowis, Jenny Adamski, John Paul Kilday, Rachel Cox, Mike Gattens, Andrew Moore, Toby Trahair, Milind Ronghe, Martin Campbell, Helen Campbell, Molly W. Williams, Maria Kirby, Natasha Van Eijkelenburg, Jennifer Keely, Ugo Scarpa, Victoria Stavrou, Livingstone Fultang, Sarah Booth, Paul Cheng, Carmela De Santo, Francis Mussai

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