Should the Food and Drug Administration Limit Placebo-Controlled Trials? by Max Goodman, Connor Pedersen

“…The FDA has been lagging in altering its policies regarding PCTs, only advising against PCT research in select oncological cases for the first time in 2019 in a nonbinding guidance. …”
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Should the Food and Drug Administration Limit Placebo-Controlled Trials? by Max Goodman, Connor Pedersen

“…The FDA has been lagging in altering its policies regarding PCTs, only advising against PCT research in select oncological cases for the first time in 2019 in a nonbinding guidance. …”
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Abrocitinib, tralokinumab and upadacitinib for treating moderate-to-severe atopic dermatitis by Steven J Edwards, Charlotta Karner, Tracey Jhita, Samantha Barton, Gemma Marceniuk, Zenas Z N Yiu, Miriam Wittmann

“…Furthermore, clinical experts advising the EAG considered combination therapy is more widely using in clinical practice in England. …”
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Some problems in the theory of the solid state by Halpern, V

“…In chapter three, we describe the various approximations which we found it necessary or advisable to make so as to be able to carry out actual calculations on the Mercury computer. …”

Colombia and Medical Tourism by Ximena Cajiao

“…In Colombia, one out of every three plastic surgery patients is an international patient.[10]  The Colombian Association for Plastic Surgery advises all patients to check the hospital's accreditation. …”
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Whole-school interventions promoting student commitment to school to prevent substance use and violence, and improve educational attainment: a systematic review by Ruth Ponsford, GJ Melendez-Torres, Alec Miners, Jane Falconer, Chris Bonell

“…We asked stakeholders to advise on interpretation, implications and knowledge exchange. …”
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Comparison of lotions, creams, gels and ointments for the treatment of childhood eczema: the BEE RCT by Matthew J Ridd, Sian Wells, Stephanie J MacNeill, Emily Sanderson, Douglas Webb, Jonathan Banks, Eileen Sutton, Alison RG Shaw, Zoe Wilkins, Julie Clayton, Amanda Roberts, Kirsty Garfield, Lyn Liddiard, Tiffany J Barrett, J Athene Lane, Helen Baxter, Laura Howells, Jodi Taylor, Alastair D Hay, Hywel C Williams, Kim S Thomas, Miriam Santer

“…Prescribers and pharmacists have an important role in ensuring that families are aware of the different emollients available, to support them in selecting a type most likely to suit them and to advise on optimal use. Verbal advice could be accompanied by written or online information (including videos) on the role of emollients and how to use them, perhaps accompanied by a planned review at the end of an agreed trial period. …”
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Resuscitation with pre-hospital blood products in adults with trauma-related haemorrhagic shock: the RePHILL RCT by Nicholas Crombie, Heidi A Doughty, Jonathan RB Bishop, Amisha Desai, Emily F Dixon, James M Hancox, Mike J Herbert, Caroline Leech, Simon J Lewis, Mark R Nash, David N Naumann, Karen Piper, Gemma Slinn, Hazel Smith, Iain M Smith, Rebekah K Wale, Alastair Wilson, Aisling Crombie, Mark Midwinter, Natalie Ives, Gavin D Perkins

“…During May 2018, the Data Monitoring Committee (DMC) reported a much higher than anticipated pooled event rate for the primary outcome (65%) to the Trial Steering Committee (TSC). The TSC advised to continue the trial with the original sample size unchanged, noting that the trial retained 80% power to detect a relative risk of 0.82 (71.7% control, 58.3% intervention). …”
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Allopurinol and cardiovascular outcomes in patients with ischaemic heart disease: the ALL-HEART RCT and economic evaluation by Isla S Mackenzie, Christopher J Hawkey, Ian Ford, Nicola Greenlaw, Filippo Pigazzani, Amy Rogers, Allan D Struthers, Alan G Begg, Li Wei, Anthony J Avery, Jaspal S Taggar, Andrew Walker, Suzanne L Duce, Rebecca J Barr, Jennifer S Dumbleton, Evelien D Rooke, Jonathan N Townend, Lewis D Ritchie, Thomas M MacDonald

“…When the screening results were available, a nurse telephoned the patient to advise them to start taking randomised therapy. If the screening visit eGFR result was below the exclusion limit, the participant did not receive any allopurinol and was excluded from the modified intention-to-treat (mITT) analysis population, whichever arm of the study they had been randomised to. …”
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Stratified primary care for adults with musculoskeletal pain: the STarT MSK research programme including RCTs by Foster Nadine E, Dunn Kate M, Protheroe Joanne, Hill Jonathan C, Lewis Martyn, Saunders Benjamin, Jowett Sue, Hennings Susie, Campbell Paul, Bromley Kieran, Bartlam Bernadette, Babatunde Opeyemi, Wathall Simon, Oppong Raymond, Kigozi Jesse, Chudyk Adrian

“…In work package 4, PPIE input led to improvements in wording and formatting of study documents, and advised on acceptable methods for GPs seeking patient consent. …”
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