Human African trypanosomiasis research gets a boost: unraveling the tsetse genome. by Serap Aksoy, Geoffrey Attardo, Matt Berriman, Alan Christoffels, Mike Lehane, Dan Masiga, Yeya Toure

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Early prediction of treatment efficacy in second-stage gambiense human African trypanosomiasis. by Gerardo Priotto, François Chappuis, Mathieu Bastard, Laurence Flevaud, Jean-François Etard

“…BACKGROUND: Human African trypanosomiasis is fatal without treatment. The long post-treatment follow-up (24 months) required to assess cure complicates patient management and is a major obstacle in the development of new therapies. …”
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The structure of serum resistance-associated protein and its implications for human African trypanosomiasis by Zoll, S, Lane-Serff, H, Mehmood, S, Schneider, J, Robinson, CV, Carrington, M, Higgins, MK

“… <p>Only two trypanosome subspecies are able to cause human African trypanosomiasis. To establish an infection in human blood, they must overcome the innate immune system by resisting the toxic effects of trypanolytic factor 1 and trypanolytic factor 2. …”

Pathogenicity and virulence of African trypanosomes: From laboratory models to clinically relevant hosts by Liam J. Morrison, Pieter C. Steketee, Mabel D. Tettey, Keith R. Matthews

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The role of domestic animals in the epidemiology of human african trypanosomiasis in Ngorongoro conservation area, Tanzania by Juan P. Ruiz, Hamisi S. Nyingilili, Geofrey H. Mbata, Imna I. Malele

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Gambian human African trypanosomiasis in North West Uganda. Are we on course for the 2020 target? by Richard Selby, Charles Wamboga, Olema Erphas, Albert Mugenyi, Vincent Jamonneau, Charles Waiswa, Steve J Torr, Michael Lehane

“…In 1994, combined active and passive screening reported 1469 cases from the historic Gambian Human African Trypanosomiasis (gHAT) foci of West Nile, Uganda. …”
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Eliminating human African trypanosomiasis: where do we stand and what comes next? by Pere P Simarro, Jean Jannin, Pierre Cattand

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African Trypanosomiasis-Associated Anemia: The Contribution of the Interplay between Parasites and the Mononuclear Phagocyte System by Benoit Stijlemans, Benoit Stijlemans, Patrick De Baetselier, Patrick De Baetselier, Stefan Magez, Stefan Magez, Jo A. Van Ginderachter, Jo A. Van Ginderachter, Carl De Trez

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The Atlas of human African trypanosomiasis: a contribution to global mapping of neglected tropical diseases by Courtin Fabrice, Fèvre Eric M, Ruiz José A, Diarra Abdoulaye, Franco José R, Paone Massimo, Cecchi Giuliano, Simarro Pere P, Mattioli Raffaele C, Jannin Jean G

“…<p>Abstract</p> <p>Background</p> <p>Following World Health Assembly resolutions 50.36 in 1997 and 56.7 in 2003, the World Health Organization (WHO) committed itself to supporting human African trypanosomiasis (HAT)-endemic countries in their efforts to remove the disease as a public health problem. …”
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Healthcare Management of Human African Trypanosomiasis Cases in the Eastern, Muchinga and Lusaka Provinces of Zambia by Allan Mayaba Mwiinde, Martin Simuunza, Boniface Namangala, Chitalu Miriam Chama-Chiliba, Noreen Machila, Neil E. Anderson, Peter M. Atkinson, Susan C. Welburn

Subjects: “…human African trypanosomiasis…”
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Development of Reduced Peptide Bond Pseudopeptide Michael Acceptors for the Treatment of Human African Trypanosomiasis by Santo Previti, Roberta Ettari, Carla Di Chio, Rahul Ravichandran, Marta Bogacz, Ute A. Hellmich, Tanja Schirmeister, Sandro Cosconati, Maria Zappalà

“…Human African Trypanosomiasis (HAT) is an endemic protozoan disease widespread in the sub-Saharan region that is caused by <i>T. b. gambiense</i> and <i>T. b. rhodesiense</i>. …”
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SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis. by Robert T Jacobs, Bakela Nare, Stephen A Wring, Matthew D Orr, Daitao Chen, Jessica M Sligar, Matthew X Jenks, Robert A Noe, Tana S Bowling, Luke T Mercer, Cindy Rewerts, Eric Gaukel, Jennifer Owens, Robin Parham, Ryan Randolph, Beth Beaudet, Cyrus J Bacchi, Nigel Yarlett, Jacob J Plattner, Yvonne Freund, Charles Ding, Tsutomu Akama, Y-K Zhang, Reto Brun, Marcel Kaiser, Ivan Scandale, Robert Don

“…<h4>Background</h4>Human African trypanosomiasis (HAT) is an important public health problem in sub-Saharan Africa, affecting hundreds of thousands of individuals. …”
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Prevalence of dermal trypanosomes in suspected and confirmed cases of gambiense human African trypanosomiasis in Guinea. by Alseny M'mah Soumah, Mariame Camara, Justin Windingoudi Kaboré, Ibrahim Sadissou, Hamidou Ilboudo, Christelle Travaillé, Oumou Camara, Magali Tichit, Jacques Kaboré, Salimatou Boiro, Aline Crouzols, Jean Marc Tsagmo Ngoune, David Hardy, Aïssata Camara, Vincent Jamonneau, Annette MacLeod, Jean-Mathieu Bart, Mamadou Camara, Bruno Bucheton, Brice Rotureau

“…The skin is an anatomical reservoir for African trypanosomes, yet the prevalence of extravascular parasite carriage in the population at risk of gambiense Human African Trypanosomiasis (gHAT) remains unclear. Here, we conducted a prospective observational cohort study in the HAT foci of Forecariah and Boffa, Republic of Guinea. …”
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Incorporating scale dependence in disease burden estimates: the case of human African trypanosomiasis in Uganda. by Finola Hackett, Lea Berrang Ford, Eric Fèvre, Pere Simarro

“…We mapped spatial variation in the burden of human African trypanosomiasis (HAT) in Uganda for the years 2000-2009. …”
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Focus-specific clinical profiles in human African Trypanosomiasis caused by Trypanosoma brucei rhodesiense. by Lorna M MacLean, Martin Odiit, John E Chisi, Peter G E Kennedy, Jeremy M Sternberg

“…Diverse clinical features have been reported in human African trypanosomiasis (HAT) foci caused by Trypanosoma brucei rhodesiense (T.b.rhodesiense) giving rise to the hypothesis that HAT manifests as a chronic disease in South-East African countries and increased in virulence towards the North. …”
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Quantifying epidemiological drivers of gambiense human African Trypanosomiasis across the Democratic Republic of Congo. by Ronald E Crump, Ching-I Huang, Edward S Knock, Simon E F Spencer, Paul E Brown, Erick Mwamba Miaka, Chansy Shampa, Matt J Keeling, Kat S Rock

“…Gambiense human African trypanosomiasis (gHAT) is a virulent disease declining in burden but still endemic in West and Central Africa. …”
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Candidate genes-based investigation of susceptibility to Human African Trypanosomiasis in Côte d'Ivoire. by Bernardin Ahouty, Mathurin Koffi, Hamidou Ilboudo, Gustave Simo, Enock Matovu, Julius Mulindwa, Christiane Hertz-Fowler, Bruno Bucheton, Issa Sidibé, Vincent Jamonneau, Annette MacLeod, Harry Noyes, Simon-Pierre N'Guetta, TrypanoGEN Research Group as members of The H3Africa Consortium

“…Human African Trypanosomiasis (HAT) or sleeping sickness is a Neglected Tropical Disease. …”
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Development of a safer laboratory vervet monkey model for the study of human African trypanosomiasis by Maxwell Waema, Naomi Maina, Simon Karanja, Beatrice Gachie, Maina Ngotho, John Kagira

“…Identifying an animal model of T. b. brucei that mimics human African trypanosomiasis (HAT) would enable researchers to study HAT without subjecting themselves to undue risks such as accidental infection. …”
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Melarsoprol cyclodextrin inclusion complexes as promising oral candidates for the treatment of human African trypanosomiasis. by Jean Rodgers, Amy Jones, Stéphane Gibaud, Barbara Bradley, Christopher McCabe, Michael P Barrett, George Gettinby, Peter G E Kennedy

“…Human African trypanosomiasis (HAT), or sleeping sickness, results from infection with the protozoan parasites Trypanosoma brucei (T. b.) gambiense or T. b. rhodesiense and is invariably fatal if untreated. …”
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The genome sequence of Trypanosoma brucei gambiense, causative agent of chronic human african trypanosomiasis. by Andrew P Jackson, Mandy Sanders, Andrew Berry, Jacqueline McQuillan, Martin A Aslett, Michael A Quail, Bridget Chukualim, Paul Capewell, Annette MacLeod, Sara E Melville, Wendy Gibson, J David Barry, Matthew Berriman, Christiane Hertz-Fowler

“…Trypanosoma brucei gambiense is the causative agent of chronic Human African Trypanosomiasis or sleeping sickness, a disease endemic across often poor and rural areas of Western and Central Africa. …”
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