Review of The Story of Alderley Edge website by Don Henson

“…Alderley Edge is an example of an archaeological site that defies easy categorisation or definition. …”
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S124: PHOSPHOPROTEOMICS ACCURATELY PREDICTS RESPONSES TO MIDOSTAURIN PLUS CHEMOTHERAPY IN TWO INDEPENDENT COHORTS OF FLT3 MUTANT-POSITIVE ACUTE MYELOID LEUKAEMIA by Arran Dokal, Weronika E. Borek, Luis Nobre, Salvatore Federico Pedicona, Bela Wrench, Paolo Gallipoli, Andrea Arruda, Amy E. Campbell, Nazrath Nawaz, Harriet R. Ferguson, David N. Perkins, Pedro Moreno-Cardoso, Andrew Thompson, Andrew J.K. Williamson, Mark D. Minden, John G. Gribben, David J. Britton, Pedro R. Cutillas

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4 Combinations of immune checkpoint inhibitors with fractionated radiotherapy or DNA damage response agents leads to improved anti-tumour responses and modulates the tumour immune... by Emily Wright, Stewart Brown, Lorraine Mooney, Charlotte Bell, Nick Moore, Theoni Katopodi, Yin Xin Ho, Lyndsey Hanson, Amy Cantrell, Jane Kendrew, Pablo Binder, Tobias Bunday, Paul Farrington, Shannon Sharman

1451 The implantation site impacts the tumour growth kinetics and tumour immune infiltrate in EO771 and 4T1 syngeneic breast cancer models by Emily Wright, Stewart Brown, Lorraine Mooney, Charlotte Bell, Nick Moore, Theoni Katopodi, Yin Xin Ho, Lyndsey Hanson, Amy Cantrell, Jane Kendrew

RUNX1 marks a luminal castration-resistant lineage established at the onset of prostate development by Renaud Mevel, Ivana Steiner, Susan Mason, Laura CA Galbraith, Rahima Patel, Muhammad ZH Fadlullah, Imran Ahmad, Hing Y Leung, Pedro Oliveira, Karen Blyth, Esther Baena, Georges Lacaud

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High throughput diagnostics and dynamic risk assessment of SARS-CoV-2 variants of concern by Alfredo Maria Gravagnuolo, Layla Faqih, Cara Cronshaw, Jacquelyn Wynn, Paul Klapper, Mark Wigglesworth

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An adaptable in vitro cytokine release assay (CRA): Susceptibility to cytokine storm in COVID-19 as a model by Masih Alam, Rawshan Choudhury, Robert-Jan Lamers

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Introduction to library administration/ by 206632 Neal, Kenneth William

Rituximab and obinutuzumab differentially hijack the B cell receptor and NOTCH1 signaling pathways by Jennifer Edelmann, Arran D. Dokal, Emma Vilventhraraja, Karlheinz Holzmann, David Britton, Tetyana Klymenko, Hartmut Döhner, Mark Cragg, Andrejs Braun, Pedro Cutillas, John G. Gribben

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External validation of a minimal-resource model to predict reduced estimated glomerular filtration rate in people with type 2 diabetes without diagnosis of chronic kidney disease i... by Camilla Sammut-Powell, Rose Sisk, Ruben Silva-Tinoco, Gustavo de la Pena, Paloma Almeda-Valdes, Paloma Almeda-Valdes, Sonia Citlali Juarez Comboni, Susana Goncalves, Rory Cameron

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Translational Roadmap for the Organs-on-a-Chip Industry toward Broad Adoption by Vanessa Allwardt, Alexander J. Ainscough, Priyalakshmi Viswanathan, Stacy D. Sherrod, John A. McLean, Malcolm Haddrick, Virginia Pensabene

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LKB1 and AMPKα1 are required in pancreatic alpha cells for the normal regulation of glucagon secretion and responses to hypoglycemia by Gao Sun, Gabriela da Silva Xavier, Tracy Gorman, Claire Priest, Antonia Solomou, David J. Hodson, Marc Foretz, Benoit Viollet, Pedro-Luis Herrera, Helen Parker, Frank Reimann, Fiona M. Gribble, Stephanie Migrenne, Christophe Magnan, Anna Marley, Guy A. Rutter

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A Systematic Comparative Assessment of the Response of Ovarian Cancer Cells to the Chemotherapeutic Cisplatin in 3D Models of Various Structural and Biochemical Configurations—Does... by Priyanka Gupta, Aline Miller, Adedamola Olayanju, Thumuluru Kavitha Madhuri, Eirini Velliou

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Head and Neck Squamous Cell Carcinoma Biopsies Maintained Ex Vivo on a Perfusion Device Show Gene Changes with Time and Clinically Relevant Doses of Irradiation by Victoria Green, Lydia Baldwin, James England, Gayle Marshall, Lucy Frost, Craig Moore, John Greenman

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Corrigendum: DeepCarc: Deep learning-powered carcinogenicity prediction using model-level representation by Ting Li, Ting Li, Weida Tong, Ruth Roberts, Ruth Roberts, Zhichao Liu, Shraddha Thakkar

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Editorial: Advancing Genomics for Rare Disease Diagnosis and Therapy Development by Zhichao Liu, Ruth Roberts, Ruth Roberts, Ruth Roberts, Tieliu Shi, Mike Mikailov, Weida Tong

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In-Vitro Approaches to Predict and Study T-Cell Mediated Hypersensitivity to Drugs by Sean Hammond, Sean Hammond, Paul Thomson, Xiaoli Meng, Dean Naisbitt

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The social organisation of metalworking in southern England during the Beaker period and Bronze Age: absence of evidence or evidence of absence? by Andy M. Jones, Michael J Allen, Gill Juleff

“…Likewise, there have also been significant advances in our understanding of the prehistoric mining of metals across the British Isles, with Beaker and Bronze Age mines identified in locations such as Ross Island (Ireland), the Great Orme (UK) and Alderley Edge (UK). Consequently, there is detailed archaeological knowledge about the two ends of the metalworking spectrum: the obtaining of the metal ores from the ground and the finished artefacts. …”
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RARβ Expression in Keratinocytes from Potentially Malignant Oral Lesions: The Functional Consequences of Re-Expression by De-Methylating Agents by Raghu Radhakrishnan, Hannah L. Crane, Marc Daigneault, Kanaka Sai Ram Padam, Keith D. Hunter

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DeepCarc: Deep Learning-Powered Carcinogenicity Prediction Using Model-Level Representation by Ting Li, Ting Li, Weida Tong, Ruth Roberts, Ruth Roberts, Zhichao Liu, Shraddha Thakkar

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