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Anti-Tumor Efficacy of PD-L1 Targeted Alpha-Particle Therapy in a Human Melanoma Xenograft Model
Published 2021-03-01“…Because of its expression on the tumor cells and on immunosuppressive cells within the tumor microenvironment, PD-L1 represents an interesting target for targeted alpha-particle therapy (TAT). We developed a TAT approach in a human melanoma xenograft model that stably expresses PD-L1 using a <sup>213</sup>Bi-anti-human-PD-L1 mAb. …”
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High scintillation yield and fast response to alpha particles from thin perovskite films deposited by pulsed laser deposition
Published 2022-10-01Subjects: Get full text
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Global gene expression analyses of bystander and alpha particle irradiated normal human lung fibroblasts: Synchronous and differential responses
Published 2008-12-01“…To provide insight into the signaling pathways responding in bystanders, we have measured global gene expression four hours after bystander and direct alpha particle exposure of primary human lung fibroblasts.…”
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Synthesis and Evaluation of a Dimeric RGD Peptide as a Preliminary Study for Radiotheranostics with Radiohalogens
Published 2021-10-01Subjects: Get full text
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Electro-Precipitation of Actinides on Boron-Doped Diamond Thin Films for Solid Sources Preparation for High-Resolution Alpha-Particle Spectrometry
Published 2019-04-01Subjects: Get full text
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Effect of ZnO Addition and of Alpha Particle Irradiation on Various Properties of Er3+, Yb3+ Doped Phosphate Glasses
Published 2017-10-01Subjects: Get full text
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Alpha Particle Emitter Radiolabeled Antibody for Metastatic Cancer: What Can We Learn from Heavy Ion Beam Radiobiology?
Published 2012-06-01Subjects: Get full text
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An experimental cross-section measurement of 10B(n,α)7Li reaction on counting alpha particles track density
Published 2018-09-01“…The mathematical model of the cross section developed here gives the relationship between alpha particle emitting from the (n, α) reaction and the number of tracks created and distribution of tracks created on the surface of the track detector. …”
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Dependence of alpha-particle-driven Alfvén eigenmode linear stability on device magnetic field strength and consequences for next-generation tokamaks
Published 2020“…AEs are sensitive to device magnetic field via the field dependence of resonances, alpha particle beta, and alpha orbit width. We describe the origin and effect of these dependences analytically and by using recently-developed numerical techniques (Rodrigues et al 2015 Nucl. …”
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Do the various radiations present in BNCT act synergistically? Cell survival experiments in mixed alpha-particle and gamma-ray fields.
Published 2009“…An irradiation setup has been created at the Medical Research Council in Harwell to allow simultaneous irradiation of cells by cobalt-60 gamma rays and plutonium-238 alpha-particles. The setup allows for variation of dose and dose rates for both sources along with variation of the alpha particle energy. …”
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Yields of SSB and DSB induced in DNA by Al(K) ultrasoft X-rays and alpha-particles: comparison of experimental and simulated yields.
Published 2001“…MATERIALS AND METHODS: Aerobic, aqueous solutions of plasmid DNA were irradiated at 277K with 238Pu alpha-particles or USX in the presence of 10(-4) to 0.33 mol dm(-3) Tris and the yields of SSB and DSB determined by gel electrophoresis. …”
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Small-scale (sub-organ and cellular level) alpha-particle dosimetry methods using an iQID digital autoradiography imaging system
Published 2022-10-01“…Abstract Targeted radiopharmaceutical therapy with alpha-particle emitters (αRPT) is advantageous in cancer treatment because the short range and high local energy deposition of alpha particles enable precise radiation delivery and efficient tumor cell killing. …”
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A multi-MeV alpha particle source via proton-boron fusion driven by a 10-GW tabletop laser
Published 2023-02-01Get full text
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