Comparative analysis of drug-salt-polymer interactions by experiment and molecular simulation improves biopharmaceutical performance by Sumit Mukesh, Goutam Mukherjee, Ridhima Singh, Nathan Steenbuck, Carolina Demidova, Prachi Joshi, Abhay T. Sangamwar, Rebecca C. Wade

“…Here, we describe a comparative experimental and computational characterization of amorphous solid dispersions containing the drug celecoxib, and a polymer, polyvinylpyrrolidone vinyl acetate (PVP-VA) or hydroxypropyl methylcellulose acetate succinate, with or without Na+/K+ salts. …”
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Combining Co-Amorphous-Based Spray Drying with Inert Carriers to Achieve Improved Bioavailability and Excellent Downstream Manufacturability by Yingxi Zhang, Yuan Gao, Xiaoxiao Du, Rou Guan, Zhonggui He, Hongzhuo Liu

“…Here, we report on a co-amorphous solid dispersion (SD) system that includes inert carriers (lactose monohydrate or microcrystalline cellulose) and co-amorphous sacubitril (SAC)-valsartan (VAL) using the spray drying process. …”
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Applicability of an Experimental Grade of Hydroxypropyl Methylcellulose Acetate Succinate as a Carrier for Formation of Solid Dispersion with Indomethacin by Hiroshi Ueda, Yuya Hirakawa, Hironori Tanaka, Tetsuya Miyano, Katsuji Sugita

“…The formation of a homogeneous amorphous solid dispersion between MX and indomethacin was confirmed by X-ray powder diffraction analysis, DSC, and Raman mapping. …”
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3D visualization of mitochondrial solid-phase calcium stores in whole cells by Sharon Grayer Wolf, Yael Mutsafi, Tali Dadosh, Tal Ilani, Zipora Lansky, Ben Horowitz, Sarah Rubin, Michael Elbaum, Deborah Fass

“…We present here the direct 3D visualization of mitochondrial calcium in intact mammalian cells using cryo-scanning transmission electron tomography (CSTET). Amorphous solid granules containing calcium and phosphorus were pervasive in the mitochondrial matrices of a variety of mammalian cell types. …”
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Utilising Co-Axial Electrospinning as a Taste-Masking Technology for Paediatric Drug Delivery by Hend E. Abdelhakim, Alastair Coupe, Catherine Tuleu, Mohan Edirisinghe, Duncan Q. M. Craig

“…Solid-state characterization and thermal analysis confirmed that amorphous solid dispersions were formed upon electrospinning. …”
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The proton density of states in confined water (H2O) by Chen, Sow-Hsin, Corsaro, Carmelo, Mallamace, Francesco, Fazio, Enza, Mallamace, Domenico

“…The liquid–liquid transition and the dynamical crossover from the fragile (super-Arrhenius) to strong (Arrhenius) glass forming behavior have been studied, by taking into account the system polymorphism in both the liquid and amorphous solid phases. The interest is focused in the low energy region of the DOS ( E<10 meV) and the data are discussed in terms of the energy landscape (local minima of the potential energy) approach. …”
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A Microscale Analysis of Millimeter-wave Induced Vitrified Basalt for Use in Enhanced Geothermal Energy Systems by Meltzer, Eve

“…The results presented in this thesis show the creation of a non-crystalline amorphous solid that has relatively high strength values with slight evidence of micro-cracking. …”
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Pressure-induced amorphization and polyamorphism: Inorganic and biochemical systems by Machon, D, Meersman, F, Wilding, M, Wilson, M, McMillan, P

“…Pressure-induced amorphization (PIA) is a phenomenon that involves an abrupt transition between a crystalline material and an amorphous solid through application of pressure at temperatures well below the melting point or glass transition range. …”

10122 Development of an In Vitro in Vivo Correlation of Itraconazole Spray-Dried Dispersion Tablets by Ana Luisa Coutinho, Asmita Adhikari, James Polli

“…We manufactured fast-, medium-, and slow-release SDD tablets containing amorphous solid dispersion of itraconazole (100 mg) and different grades of the polymer hypromellose acetate succinate (HPMC-AS). …”
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One-Step Preparation of Fiber-Based Chlorzoxazone Solid Dispersion by Centrifugal Spinning by Enikő Bitay, Attila Levente Gergely, Zoltán-István Szabó

“…The obtained results indicate that centrifugal spinning is a low-cost, high-yield, viable alternative to the currently used methods to prepare fiber-based amorphous solid dispersions of poorly soluble drugs. The prepared chlorzoxazone-loaded microfibers could be used as a buccal dosage form for the systematic delivery of chlorzoxazone and could potentially lead to a rapid onset of action and longer efficacy of the muscle relaxant drug.…”
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Impact of Poloxamer on Crystal Nucleation and Growth of Amorphous Clotrimazole by Jie Zhang, Ziqing Yang, Liquan Luo, Kang Li, Taotao Zi, Junjie Ren, Lei Pan, Ziyue Wang, Zihao Wang, Minzhuo Liu, Zhihong Zeng

“…Surfactants have been widely used as effective additives to increase the solubility and dissolution rates of amorphous solid dispersions (ASDs). However, they may also generate adverse effects on the physical stability of ASDs. …”
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Synthesis of aromatic polynitroso compounds: Towards functional azodioxy-linked porous polymers by Nikola Cindro, Željka Car, Vesna Petrović Peroković, Mladen Borovina, Barbara Panić, Ivan Kodrin, Ivana Biljan

“…While azodioxy polymer with triphenylbenzene moiety is an amorphous solid, other azodioxy oligomers and polymers displayed sharp diffraction peaks pointing to their crystalline nature. …”
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Removal of Arsenate and Arsenite in Equimolar Ferrous and Ferric Sulfate Solutions through Mineral Coprecipitation: Formation of Sulfate Green Rust, Goethite, and Lepidocrocite by Chunming Su, Richard T. Wilkin

“…X-ray analysis indicated that amorphous solid products were formed at 10–100 mM As(V) or 100 mM As(III). …”
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Reliable Characterization of Organic & Pharmaceutical Compounds with High Resolution Monochromated EEL Spectroscopy by Partha Pratim Das, Giulio Guzzinati, Catalina Coll, Alejandro Gomez Perez, Stavros Nicolopoulos, Sonia Estrade, Francesca Peiro, Johan Verbeeck, Aikaterini A. Zompra, Athanassios S. Galanis

“…As many new API (active pharmaceutical ingredients) and their polymorphs are in nanocrystalline or in amorphous form blended with amorphous polymeric matrix (known as amorphous solid dispersion—ASD), their structural identification and characterization at nm scale with conventional X-Ray/Raman/IR techniques becomes difficult. …”
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Morphological characterization of biominerals from five multicellular marine algae species by A. M. Zakharenko, M. A. Nawaz, V. V. Chaika, I. V. Zemchenko, T. Yu. Orlova, A. A. Begun, R. V. Romashko, A. N. Galkina, A. A. Karabtsov, G. Chung, K. S. Golokhvast

“…Silica biominerals are deposited as amorphous solid structures in plant cells and tissues, providing rigidity to different plant parts and assisting in defence. …”
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Orodispersible Polymer Films with the Poorly Water-Soluble Drug, Olanzapine: Hot-Melt Pneumatic Extrusion for Single-Process 3D Printing by Hui-Won Cho, Seung-Hoon Baek, Beom-Jin Lee, Hyo-Eon Jin

“…Amorphous solid dispersions (ASDs) improve the oral delivery of poorly water-soluble drugs. …”
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Constructing a LiPON Layer on a 3D Lithium Metal Anode as an Artificial Solid Electrolyte Interphase with Long-Term Stability by Qianmu Pan, Yongkun Yu, Yuxin Zhu, Chunli Shen, Minjian Gong, Kui Yan, Xu Xu

“…Lithium phosphorus oxynitride (LiPON), functioning as an amorphous solid electrolyte, is extensively employed as an artificial solid electrolyte interphase (SEI) owing to its remarkable stability and mechanical strength, which is beneficial for effectively mitigating dendrite growth. …”
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Composition Dependency of the Flory–Huggins Interaction Parameter in Drug–Polymer Phase Behavior by Jana Klueppelberg, Ulrich A. Handge, Markus Thommes, Judith Winck

“…An innovative strategy to address recent challenges in the oral administration of poorly soluble drugs is the formulation of amorphous solid dispersions (ASDs), where the drug is dissolved in a highly soluble carrier polymer. …”
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Newly engineered alumina quantum dot-based nanofluid in enhanced oil recovery at reservoir conditions by Nosrat Izadi, Bahram Nasernejad

“…Abstract In this work, a newly engineered alumina quantum dot-based nanofluid (α-AQDs; D ~ 4 nm; amorphous solid) and one commercial alumina nanoparticle-based nanofluid (γ-ANPs; D ~ 20 nm; crystalline type) with the capability of strong colloidal dispersion at reservoir conditions, such as, high salinity, divalent ions (Ca2+) and high temperature was compared. …”
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Amorphous drug-polyelectrolyte nanoparticle complex with controlled release functionality, enhanced amorphous stability, and its continuous production platform by Dong, Bingxue

“…below 80:20) were proved to exhibit sustained CIP release compared to the native CIP and the binary CIP-DXT nanoplex in SGJ. Though the amorphous solid drug formation represents an attractive approach to enhance the solubility of poorly soluble drugs, they have a trait that the amorphous solid drug tends to become crystalline during storage due to the inherent thermodynamic instability. …”
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