On Absorption Modeling and Food Effect Prediction of Rivaroxaban, a BCS II Drug Orally Administered as an Immediate-Release Tablet by Varun Kushwah, Sumit Arora, Miklós Tamás Katona, Dattatray Modhave, Eleonore Fröhlich, Amrit Paudel

“…The developed models thus can be effectively extended to establish bioequivalence for the marketed and novel complex formulations of Riva such as amorphous solid dispersions.…”
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Formation of a Stable Co-Amorphous System for a Brick Dust Molecule by Utilizing Sodium Taurocholate with High Glass Transition Temperature by Shohei Aikawa, Hironori Tanaka, Hiroshi Ueda, Masato Maruyama, Kazutaka Higaki

“…However, their glass transition temperatures (<i>Tg</i>) are relatively lower than those of polymeric amorphous solid dispersions, suggesting the instability of the co-amorphous system. …”
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Micro-Injection Moulding of PEO/PCL Blend–Based Matrices for Extended Oral Delivery of Fenbendazole by Gilberto S. N. Bezerra, Gabriel G. De Lima, Declan M. Colbert, Elaine Halligan, Joseph Geever, Luke Geever

“…Drug release studies attested that all moulded tablets of amorphous solid dispersions improved the drug solubility, with the PEO/PCL blend–based matrices showing drug release by Korsmeyer–Peppas kinetics. …”
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In-Line UV-Vis Spectroscopy as a Fast-Working Process Analytical Technology (PAT) during Early Phase Product Development Using Hot Melt Extrusion (HME) by Walkiria Schlindwein, Mariana Bezerra, Juan Almeida, Andreas Berghaus, Martin Owen, Gordon Muirhead

“…A sequential design of experiments (DoE) (screening, optimisation and verification) was used to gain process understanding for the manufacture of piroxicam (PRX)/Kollidon&reg; VA64 amorphous solid dispersions. The influence of die temperature, screw speed, solid feed rate and PRX concentration on the critical quality attributes (CQAs) absorbance and lightness of color (L*) of the extrudates was investigated using multivariate tools. …”
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Advancement in Solubilization Approaches: A Step towards Bioavailability Enhancement of Poorly Soluble Drugs by Lakshmi Kumari, Yash Choudhari, Preeti Patel, Ghanshyam Das Gupta, Dilpreet Singh, Jessica M. Rosenholm, Kuldeep Kumar Bansal, Balak Das Kurmi

“…It includes structural modification (i.e., prodrug, salt formation, co-crystallization, use of co-solvents, hydrotrophy, polymorphs, amorphous solid dispersions, and pH variation). Various nanotechnological approaches such as liposomes, nanoparticles, dendrimers, micelles, metal organic frameworks, nanogels, nanoemulsions, nanosuspension, carbon nanotubes, and so forth have also been widely investigated for solubility enhancement. …”
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Macrofilaricidal efficacy of single and repeated oral and subcutaneous doses of flubendazole in Litomosoides sigmodontis infected jirds. by Marc P Hübner, Alexandra Ehrens, Marianne Koschel, Bettina Dubben, Franziska Lenz, Stefan J Frohberger, Sabine Specht, Ludo Quirynen, Sophie Lachau-Durand, Fetene Tekle, Benny Baeten, Marc Engelen, Charles D Mackenzie, Achim Hoerauf

“…In the present study the efficacy of a newly developed bioavailable amorphous solid dispersion (ASD) oral formulation of FBZ was investigated in the Litomosoides sigmodontis jird model. …”
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Complex dispersions of poloxamers and mesoporous carriers with ibrutinib by Igor A. Dain, Sergey A. Zolotov, Natalia B. Demina, Anna S. Zolotova, Grigorii A. Buzanov, Vasilii M. Retivov, Yevgenii S. Ponomaryov

“…This study reports on the study of the effectiveness of mesoporous carriers based on magnesium aluminometasilicate and poloxamers to improve the solubility and bioavailability of ibrutinib in the form of amorphous solid dispersions. The choice of the most effective composition was made on a parallel study of (a) a physical mixture of ibrutinib with a mesoporous carrier, (b) a solid dispersion with a poloxamer on a non-porous carrier, (c) a dispersion with a poloxamer deposited on a mesoporous carrier. …”
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SEDEX—Self-Emulsifying Delivery Via Hot Melt Extrusion: A Continuous Pilot-Scale Feasibility Study by Ožbej Zupančič, Aygün Doğan, Josip Matić, Varun Kushwah, Carolina Alva, Martin Spoerk, Amrit Paudel

“…In conclusion, processing SEDDSs with HME could be considered a promising alternative to the established solidification techniques as well as classic amorphous solid dispersions for drug delivery.…”
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The Effect of Molecular Properties on Active Ingredient Release from Electrospun Eudragit Fibers by Kieran Burgess, Heyu Li, Yasmin Abo-zeid, Fatimah, Gareth R. Williams

“…The resultant fibers were smooth and cylindrical in the majority of cases, and X-ray diffraction and differential scanning calorimetry showed them to comprise amorphous solid dispersions. When AI release from the monolithic fibers was probed, it was found that there was significant release at pH 1 in all cases except with 9-anthracene carboxylic acid. …”
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Photon energy storage materials with high energy densities based on diacetylene–azobenzene derivatives by Han, Ggoch Ddeul, Park, Sarah Sunah, Liu, Y., Zhitomirsky, David, Cho, Eugene Nammyoung, Dinca, Mircea, Grossman, Jeffrey C.

“…The extra energy storage in the materials in addition to the isomerization enthalpy of azobenzene units is enabled by the different phase of materials in the ground state (crystalline solid) and in metastable state (amorphous solid/liquid). It is notable that the phase change characteristic of organic materials can be a parameter to consider in terms of designing high energy density photon energy storage materials.…”
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In Situ Characterization of Pharmaceutical Formulations by Dynamic Nuclear Polarization Enhanced MAS NMR by Ni, Qing Zhe, Yang, Fengyuan, Can, Thach V., Sergeyev, Ivan V., D’Addio, Suzanne M., Jawla, Sudheer K., Li, Yongjun, Lipert, Maya P., Xu, Wei, Williamson, R. Thomas, Leone, Anthony, Griffin, Robert G., Su, Yongchao

“…Here, we demonstrate that DNP polarizing agents can be added in situ during the preparation of amorphous solid dispersions (ASDs) via spray drying and hot-melt extrusion so that ASDs can be examined during drug development. …”
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New Tools for Structural Biology and Biophysics: High-Throughput Fluorine Solid-State NMR and Applications to Membrane Proteins by Shcherbakov, Alexander A.

“…Solid-State Nuclear Magnetic Resonance (SSNMR) spectroscopy is a powerful method for characterizing the structure and dynamics of crystalline and amorphous solid compounds, materials, and biological systems. …”
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A trade-off between solubility enhancement and physical stability upon simultaneous amorphization and nanonization of curcumin in comparison to amorphization alone by Wong, Jerome Jie Long, Yu, Hong, Lim, Li Ming, Hadinoto, Kunn

“…While amorphization of CUR via amorphous solid dispersion (ASD) represents a well-established CUR solubility enhancement strategy, simultaneous amorphization and nanonization of CUR via amorphous CUR nanoparticles (or nano-CUR in short) have emerged only recently as the plausibly superior alternative to ASD. …”
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Short-course, oral flubendazole does not mediate significant efficacy against Onchocerca adult male worms or Brugia microfilariae in murine infection models by Sjoberg, HT, Pionnier, N, Aljayyoussi, G, Metuge, HM, Njouendou, AJ, Chunda, VC, Fombad, FF, Tayong, DB, Gandjui, NVT, Akumtoh, DN, Chounna, PWN, Ndzeshang, BL, Lachaud, S, Tekle, F, Quirynen, L, Engelen, M, Baeten, B, Steven, A, Ward, SA, Taylor, MJ, Wanji, S, Turner, JD

“…The purpose of this study was to assess whether 5 daily sub-cutaneous (s.c.) injections of standard flubendazole (FBZ) suspension (10mg/kg), a single s.c. injection (10mg/kg) or 5 daily repeated oral doses of FBZ amorphous solid dispersion (ASD) formulation (0.2, 1.5 or 15mg/kg) mediated macrofilaricidal efficacy against O. ochengi male worms implanted into SCID mice. …”

The Impact of Water-Soluble Chitosan on the Inhibition of Crystal Nucleation of Alpha-Mangostin from Supersaturated Solutions by Arif Budiman, Nisrina Nurfadilah, Muchtaridi Muchtaridi, Sriwidodo Sriwidodo, Diah Lia Aulifa, Agus Rusdin

“…This is because the drug in the supersaturation system has a high energy state with a tendency to precipitate. In the amorphous solid dispersion (ASD) formulation, it was discovered that polymer plays a critical role in inhibiting nucleation or crystal growth of the drugs. …”
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Pharmaceutical Cocrystal Development of TAK-020 with Enhanced Oral Absorption by Kouya Kimoto, Mitsuo Yamamoto, Masatoshi Karashima, Miyuki Hohokabe, Junpei Takeda, Katsuhiko Yamamoto, Yukihiro Ikeda

“…Furthermore, its absorption was remarkable and beyond those achieved in currently existing solubilized formulation techniques, such as nanocrystal, amorphous solid dispersion, and lipid-based formulation, in dog pharmacokinetic studies. …”
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Prediction of Solid-State Form of SLS 3D Printed Medicines Using NIR and Raman Spectroscopy by Sarah J. Trenfield, Patricija Januskaite, Alvaro Goyanes, David Wilsdon, Martin Rowland, Simon Gaisford, Abdul W. Basit

“…Selective laser sintering (SLS) 3D printing is capable of revolutionising pharmaceutical manufacturing, by producing amorphous solid dispersions in a one-step manufacturing process. …”
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Characterization of Different Salt Forms of Chitooligosaccharides and Their Effects on Nitric Oxide Secretion by Macrophages by Ronge Xing, Chaojie Xu, Kun Gao, Haoyue Yang, Yongliang Liu, Zhaoqian Fan, Song Liu, Yukun Qin, Huahua Yu, Pengcheng Li

“…The results showed that pure chitooligosaccharide was an irregular spherical shape with rough surface, and its different salt type products are amorphous solid with different honeycomb sizes. In addition to the characteristic absorption peaks of chitooligosaccharides, in FTIR, the characteristic absorption of carboxyl group, methylene group, and aromatic group in corresponding acid appeared. …”
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Insights from the quantitative calibration of an elasto-plastic model from a Lennard-Jones atomic glass by Fernández Castellanos, David, Roux, Stéphane, Patinet, Sylvain

“…Here, we compare the macroscopic and the local plastic behavior of a model amorphous solid based on two radically different numerical descriptions. …”
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Heterogeneous ice nucleation of viscous secondary organic aerosol produced from ozonolysis of α-pinene by Ignatius, Karoliina, Kristensen, Thomas B., Järvinen, Emma, Nichman, Leonid, Fuchs, Claudia, Gordon, Hamish, Herenz, Paul, Hoyle, Christopher R., Duplissy, Jonathan, Garimella, Sarvesh, Dias, Antonio, Frege, Carla, Höppel, Niko, Tröstl, Jasmin, Wagner, Robert, Yan, Chao, Amorim, Antonio, Baltensperger, Urs, Curtius, Joachim, Donahue, Neil M., Gallagher, Martin W., Kirkby, Jasper, Kulmala, Markku, Möhler, Ottmar, Saathoff, Harald, Schnaiter, Martin, Tomé, Antonio, Virtanen, Annele, Worsnop, Douglas, Stratmann, Frank

“…There are strong indications that particles containing secondary organic aerosol (SOA) exhibit amorphous solid or semi-solid phase states in the atmosphere. …”
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