Plasma amyloid beta biomarkers predict amyloid positivity and longitudinal clinical progression in mild cognitive impairment by Takuya Ataka, Noriyuki Kimura, Naoki Kaneko, Teruaki Masuda, Yosuke Takeuchi, Kenichi Yabuuchi, Takeshi Mizukami, Tsukasa Takeuchi, Temmei Ito, Hideaki Tasai, Takehiko Miyagawa, Shunya Hanai, Shinichi Iwamoto, Etsuro Matsubara

“…Abstract INTRODUCTION Previous studies have examined the predictive accuracy of plasma amyloid beta (Aβ) biomarkers in clinical cohorts. However, their accuracy for predicting amyloid‐positive patients in community‐based cohorts is unclear. …”
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Nicotinamide Ameliorates Amyloid Beta-Induced Oxidative Stress-Mediated Neuroinflammation and Neurodegeneration in Adult Mouse Brain by Inayat Ur Rehman, Riaz Ahmad, Ibrahim Khan, Hyeon Jin Lee, Jungsung Park, Rahat Ullah, Myeong Jun Choi, Hee Young Kang, Myeong Ok Kim

“…Alzheimer’s disease (AD) is the most predominant age-related neurodegenerative disease, pathologically characterized by the accumulation of aggregates of amyloid beta Aβ_1–42 and tau hyperphosphorylation in the brain. …”
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Curcumin Derivative GT863 Inhibits Amyloid-Beta Production via Inhibition of Protein N-Glycosylation by Yasuomi Urano, Mina Takahachi, Ryo Higashiura, Hitomi Fujiwara, Satoru Funamoto, So Imai, Eugene Futai, Michiaki Okuda, Hachiro Sugimoto, Noriko Noguchi

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The Impact of Amyloid-Beta Positivity with 18F-Florbetaben PET on Neuropsychological Aspects in Parkinson’s Disease Dementia by Seunghee Na, Hyeonseok Jeong, Jong-Sik Park, Yong-An Chung, In-Uk Song

“…Four patients (17.4%) showed significant amyloid burden. Patients with amyloid-beta showed poorer performance in executive function and more severe neuropsychiatric symptoms than those without amyloid-beta. …”
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Higher Level of Mismatch in 4 Carriers for Amyloid-Beta Peptide Alzheimer’s Disease Biomarkers in Cerebrospinal Fluid by Jonathan Vogelgsang, Ruth Vukovich, Dirk Wedekind, Jens Wiltfang

“…Even though there is a causal correlation between apolipoprotein E ( APOE ) genotype and amyloid-beta (Aβ), the determination of APOE is currently not supported by national or international guidelines. …”
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Effect of hormone replacement therapy on amyloid beta (Aβ) plaque density in the rhesus macaque amygdala by Maria-Luisa Appleman, Jeremy L. Thomas, Alison R. Weiss, Benjamin I. Nilaver, Rita Cervera-Juanes, Steven G. Kohama, Henryk F. Urbanski, Henryk F. Urbanski, Henryk F. Urbanski

“…BackgroundAmyloid beta (Aβ) plaque density was examined in the amygdala of rhesus macaques, to elucidate the influence of age, diet and hormonal environment.MethodsLuminex technology was used to measure cerebrospinal fluid (CSF) concentrations of Aβ40 and Aβ42 across three decades, while immunohistochemistry was used to examine Aβ plaque density in the amygdala.ResultsAβ40 was found to be the predominant isoform of Aβ in the CSF, but neither Aβ40 or Aβ42 concentrations showed an age-related change, and the ratio of Aβ42 to Aβ40 showed only a marginal increase. …”
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Plasma amyloid-beta levels correlated with impaired hepatic functions: An adjuvant biomarker for the diagnosis of biliary atresia by Hongyu Lyu, Yongqin Ye, Yongqin Ye, Vincent Chi Hang Lui, Vincent Chi Hang Lui, Weifang Wu, Weifang Wu, Patrick Ho Yu Chung, Patrick Ho Yu Chung, Kenneth Kak Yuen Wong, Kenneth Kak Yuen Wong, Hung-Wing Li, Man Shing Wong, Paul Kwong Hang Tam, Bin Wang

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Bacteroidota inhibit microglia clearance of amyloid-beta and promote plaque deposition in Alzheimer’s disease mouse models by Caroline Wasén, Leah C. Beauchamp, Julia Vincentini, Shuqi Li, Danielle S. LeServe, Christian Gauthier, Juliana R. Lopes, Thais G. Moreira, Millicent N. Ekwudo, Zhuoran Yin, Patrick da Silva, Rajesh K. Krishnan, Oleg Butovsky, Laura M. Cox, Howard L. Weiner

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Do radiomics or diffusion-tensor images provide additional information to predict brain amyloid-beta positivity? by Sungyang Jo, Hyunna Lee, Hyung-Ji Kim, Chong Hyun Suh, Sang Joon Kim, Yoojin Lee, Jee Hoon Roh, Jae-Hong Lee

“…The study population included 72 patients with MCI in the amyloid-beta-negative group and 114 patients with MCI in the amyloid-beta-positive group. …”
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Amyloid Beta and Tau Cooperate to Cause Reversible Behavioral and Transcriptional Deficits in a Model of Alzheimer’s Disease by Eleanor K. Pickett, Abigail G. Herrmann, Jamie McQueen, Kimberly Abt, Owen Dando, Jane Tulloch, Pooja Jain, Sophie Dunnett, Sadaf Sohrabi, Maria P. Fjeldstad, Will Calkin, Leo Murison, Rosemary J. Jackson, Makis Tzioras, Anna Stevenson, Marie d’Orange, Monique Hooley, Caitlin Davies, Marti Colom-Cadena, Alejandro Anton-Fernandez, Declan King, Iris Oren, Jamie Rose, Chris-Anne McKenzie, Elizabeth Allison, Colin Smith, Oliver Hardt, Christopher M. Henstridge, Giles E. Hardingham, Tara L. Spires-Jones

“…Keywords: Alzheimer, synapse, amyloid beta, tau, array tomography, microglia…”
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Neurotoxicity of Amyloid Beta and its Association with other Biomarkers in Pathogenesis of Alzheimer’s Disease: A Narrative Review by Ram Prakash Sah, CS Vidya, Pratibha Pereira, Shubha Jayaram, Anshu Kumar Yadav, P Sujatha

“…Amyloid beta (Aβ) deposition in the brain is regarded as an early toxic effect in the aetiopathogenesis of Alzheimer’s Disease (AD). …”
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Amyloid-beta antibody binding to cerebral amyloid angiopathy fibrils and risk for amyloid-related imaging abnormalities by Linda Söderberg, Malin Johannesson, Eleni Gkanatsiou, Patrik Nygren, Nicolas Fritz, Olof Zachrisson, Adeline Rachalski, Anne-Sophie Svensson, Emily Button, Giacomo Dentoni, Gunilla Osswald, Lars Lannfelt, Christer Möller

“…Abstract Therapeutic antibodies have been developed to target amyloid-beta (Aβ), and some of these slow the progression of Alzheimer’s disease (AD). …”
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Synthesis, Molecular Modelling and Biological Evaluation of Novel Heterodimeric, Multiple Ligands Targeting Cholinesterases and Amyloid Beta by Michalina Hebda, Marek Bajda, Anna Więckowska, Natalia Szałaj, Anna Pasieka, Dawid Panek, Justyna Godyń, Tomasz Wichur, Damijan Knez, Stanislav Gobec, Barbara Malawska

“…Cholinesterases and amyloid beta are one of the major biological targets in the search for a new and efficacious treatment of Alzheimer’s disease. …”
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Multivariate analyses of amyloid-beta oligomer populations indicate a connection between pore formation and cytotoxicity. by Panchika Prangkio, Erik C Yusko, David Sept, Jerry Yang, Michael Mayer

“…Aggregates of amyloid-beta (Aβ) peptides are thought to be involved in the development of Alzheimer's disease because they can change synaptic plasticity and induce neuronal cell death by inflammation, oxidative damage, and transmembrane pore formation. …”
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Corrigendum to “Elevated amyloid beta peptides and total tau in cerebrospinal fluid in individuals with Creatine transporter deficiency” by Samar Rahhal, Cristan Farmer, Audrey Thurm, Christopher A. Wassif, Niamh X. Cawley, John Perreault, An Dang Do, Simona Bianconi, Fady Hannah-Shmouni, Whitney Guthrie, Laura S. Cubit, Judith S. Miller, V. Reid Sutton, Dwight Koeberl, Forbes D. Porter

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Aducanumab and lecanemab – two novel antibodies against pathologic species of amyloid beta in the treatment of Alzheimer’s disease by Jakub Wojcieszak

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Ginsenoside F1 Protects the Brain against Amyloid Beta-Induced Toxicity by Regulating IDE and NEP by Yee-Jin Yun, Bong-Hwan Park, Jingang Hou, Jung-Pyo Oh, Jin-Hee Han, Sun-Chang Kim

“…Although the effects of ginsenosides on amyloid beta (Aβ) aggregation in the brain are known, the role of ginsenoside F1 remains unclear. …”
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Triptolide Inhibited Cytotoxicity of Differentiated PC12 Cells Induced by Amyloid-Beta₂₅₋₃₅ via the Autophagy Pathway. by Pengjuan Xu, Zhigui Li, Hui Wang, Xiaochen Zhang, Zhuo Yang

“…Evidence shows that an abnormal deposition of amyloid beta-peptide25-35 (Aβ25-35) was the primary cause of the pathogenesis of Alzheimer's disease (AD). …”
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The Dual Role of Amyloid Beta-Peptide in Oxidative Stress and Inflammation: Unveiling Their Connections in Alzheimer’s Disease Etiopathology by Hugo Fanlo-Ucar, Pol Picón-Pagès, Víctor Herrera-Fernández, Gerard ILL-Raga, Francisco J. Muñoz

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Strategy to discover full-length amyloid-beta peptide ligands using high-efficiency microarray technology by Clelia Galati, Natalia Spinella, Lucio Renna, Danilo Milardi, Francesco Attanasio, Michele Francesco Maria Sciacca, Corrado Bongiorno

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