Comparison of Intensity- and Polarization-based Contrast in Amyloid-beta Plaques as Observed by Optical Coherence Tomography by Johanna Gesperger, Antonia Lichtenegger, Thomas Roetzer, Marco Augustin, Danielle J. Harper, Pablo Eugui, Conrad W. Merkle, Christoph K. Hitzenberger, Adelheid Woehrer, Bernhard Baumann

“…One key hallmark of Alzheimer’s disease (AD) is the accumulation of extracellular amyloid-beta protein in cortical regions of the brain. …”
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New Alzheimer amyloid beta responsive genes identified in human neuroblastoma cells by hierarchical clustering. by Markus Uhrig, Carina Ittrich, Verena Wiedmann, Yuri Knyazev, Annette Weninger, Matthias Riemenschneider, Tobias Hartmann

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Association of walking energetics with amyloid beta status: Findings from the Baltimore Longitudinal Study of Aging by Ryan J. Dougherty, Janani Ramachandran, Fangyu Liu, Yang An, Amal A. Wanigatunga, Qu Tian, Murat Bilgel, Eleanor M. Simonsick, Luigi Ferrucci, Susan M. Resnick, Jennifer A. Schrack

“…We investigated the cross‐sectional association between the energetic cost of walking, gait speed, and amyloid beta (Aβ) status (+/−) in older adults. Methods One hundred forty‐nine cognitively normal adults (56% women, mean age 77.5 ± 8.4 years) completed customary‐paced walking assessments with indirect calorimetry and 11C‐Pittsburgh compound B positron emission tomography. …”
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Hook proteins: association with Alzheimer pathology and regulatory role of hook3 in amyloid beta generation. by Lydia Herrmann, Caspar Wiegmann, Annika Arsalan-Werner, Isabel Hilbrich, Carsten Jäger, Katharina Flach, Anne Suttkus, Ingolf Lachmann, Thomas Arendt, Max Holzer

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Fatty Acid Amide Hydrolase (FAAH) Inhibition Modulates Amyloid-Beta-Induced Microglia Polarization by Maddalena Grieco, Maria Giovanna De Caris, Elisa Maggi, Federica Armeli, Roberto Coccurello, Tiziana Bisogno, Maria D’Erme, Mauro Maccarrone, Patrizia Mancini, Rita Businaro

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Circular RNA Encoded Amyloid Beta peptides—A Novel Putative Player in Alzheimer’s Disease by Dingding Mo, Xinping Li, Carsten A. Raabe, Timofey S. Rozhdestvensky, Boris V. Skryabin, Juergen Brosius

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Sinomenine inhibits amyloid beta-induced astrocyte activation and protects neurons against indirect toxicity by Deepali Singh, Apurva Agrawal, Chitra Mohinder Singh Singal, Hriday Shanker Pandey, Pankaj Seth, Shiv Kumar Sharma

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Clathrin mediated endocytosis in Alzheimer’s disease: cell type specific involvement in amyloid beta pathology by Sierra Jaye, Ursula S. Sandau, Julie A. Saugstad

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An atlas of amyloid aggregation: the impact of substitutions, insertions, deletions and truncations on amyloid beta fibril nucleation by Mireia Seuma, Ben Lehner, Benedetta Bolognesi

“…By comprehensively mapping the impact that different classes of mutations (substitutions, insertions, deletions) have on the ability of the amyloid beta peptide to nucleate amyloids, the authors identify a large set of likely pathogenic variants of amyloid beta that are specifically enriched at its polar N-terminal region.…”
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Amyloid beta-mediated KIF5A deficiency disrupts anterograde axonal mitochondrial movement by Qi Wang, Jing Tian, Hao Chen, Heng Du, Lan Guo

Subjects: “…Amyloid beta…”
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Competitive Mirror Image Phage Display Derived Peptide Modulates Amyloid Beta Aggregation and Toxicity. by Stephan Rudolph, Antonia Nicole Klein, Markus Tusche, Christine Schlosser, Anne Elfgen, Oleksandr Brener, Charlotte Teunissen, Lothar Gremer, Susanne Aileen Funke, Janine Kutzsche, Dieter Willbold

“…According to recent studies, oligomeric species of the amyloid beta (Aβ) peptide appear to be the most toxic Aβ assemblies. …”
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Novel Stilbene-Nitroxyl Hybrid Compounds Display Discrete Modulation of Amyloid Beta Toxicity and Structure by Silvia Hilt, Ruiwu Liu, Izumi Maezawa, Tatu Rojalin, Hnin H. Aung, Hnin H. Aung, Madhu Budamagunta, Ryan Slez, Qizhi Gong, Randy P. Carney, John C. Voss, John C. Voss

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Allium roseum L. extract inhibits amyloid beta aggregation and toxicity involved in Alzheimer's disease. by Abdelbasset Boubakri, Manuela Leri, Monica Bucciantini, Hanen Najjaa, Abdelkarim Ben Arfa, Massimo Stefani, Mohamed Neffati

“…In the present study, the inhibition of amyloid beta protein toxicity by the ethanolic extract of this plant is investigated for the first time. …”
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Computational identification of potential multitarget treatments for ameliorating the adverse effects of amyloid-beta on synaptic plasticity by Thomas J. Anastasio

“…The leading hypothesis on Alzheimer Disease (AD) is that it is caused by buildup of the peptide amyloid-beta (Abeta), which initially causes dysregulation of synaptic plasticity and eventually causes destruction of synapses and neurons. …”
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Identification of a BACE1 Binding Peptide Candidate for the Prevention of Amyloid Beta in Alzheimer’s Disease by Justin Read, Cenk Suphioglu

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Noncanonical regulation of imprinted gene Igf2 by amyloid-beta 1–42 in Alzheimer’s disease by Emre Fertan, William H. Gendron, Aimée A. Wong, Gabrielle M. Hanson, Richard E. Brown, Ian C. G. Weaver

“…Since Igf2 is an imprinted gene, we examined age and sex differences in the relationship between amyloid-beta 1–42 (Aβ 42 ) accumulation and epigenetic regulation of the Igf2/H19 gene cluster in cerebrum, liver, and plasma of young and old male and female 5xFAD mice, in frontal cortex of male and female AD and non-AD patients, and in HEK293 cell cultures. …”
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The genetic landscape for amyloid beta fibril nucleation accurately discriminates familial Alzheimer’s disease mutations by Mireia Seuma, Andre J Faure, Marta Badia, Ben Lehner, Benedetta Bolognesi

“…Plaques of the amyloid beta (Aß) peptide are a pathological hallmark of Alzheimer’s disease (AD), the most common form of dementia. …”
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Effects of apoE deficiency and occlusal disharmony on amyloid-beta production and spatial memory in rats. by Daisuke Ekuni, Yasumasa Endo, Takaaki Tomofuji, Tetsuji Azuma, Koichiro Irie, Kenta Kasuyama, Manabu Morita

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Soluble amyloid-beta buffering by plaques in Alzheimer disease dementia versus high-pathology controls. by Thomas J Esparza, Mihika Gangolli, Nigel J Cairns, David L Brody

“…An unanswered question regarding Alzheimer disease dementia (ADD) is whether amyloid-beta (Aβ) plaques sequester toxic soluble Aβ species early during pathological progression. …”
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The effect of apelin-13 on memory of scopolamine-treated rats and accumulation of amyloid-beta plaques in the hippocampus by Maryam Azhir, Sara Gazmeh, Leila Elyasi, Mehrdad Jahanshahi, Behnaz Bazrafshan

“…Regarding histological analysis, Congo red staining of the hippocampal sections was done, and immunoblotting was used to determine apoptotic biochemical markers, including caspase 3, cytochrome C, and congophilic amyloid-beta plaques. Results: Apelin–13 alleviated scopolamine-related passive avoidance memory impairment and reduced the number of congophilic amyloid-beta plaques in the hippocampus (all P<0.001). …”
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