3D microenvironments for in vitro modeling of alzheimer’s disease by Ranjan, Vivek Damodar

“…The differentiated neurons in 3D PLGA scaffold-based culture exhibited significant amplification in pathogenic amyloid-beta 42 (Aβ42) and phospho-tau (p-tau) levels between diseased and age-matched controls. …”
Get full text

Efficacy and safety of tarenflurbil in mild to moderate Alzheimer's disease: a randomised phase II trial. by Wilcock, G, Black, SE, Hendrix, S, Zavitz, K, Swabb, E, Laughlin, M

“…BACKGROUND: The amyloid-beta peptide Abeta(42) has been implicated in the pathogenesis of Alzheimer's disease (AD). …”

Biochemical markers in vascular cognitive impairment associated with subcortical small vessel disease - A consensus report by A. Wallin, E. Kapaki, M. Boban, S. Engelborghs, D. M. Hermann, B. Huisa, M. Jonsson, M. G. Kramberger, L. Lossi, B. Malojcic, S. Mehrabian, A. Merighi, E. B. Mukaetova-Ladinska, G. P. Paraskevas, B. O. Popescu, R. Ravid, L. Traykov, G. Tsivgoulis, G. Weinstein, A. Korczyn, M. Bjerke, G. Rosenberg

“…The suggested SSVD biomarker deviations contrasts the characteristic CSF profile in AD, i.e. depletion of amyloid beta peptide and increased phosphorylated and total tau. …”
Get full text

Prophylactic evaluation of verubecestat on disease‐ and symptom‐modifying effects in 5XFAD mice by Adrian L. Oblak, Zackary A. Cope, Sara K. Quinney, Ravi S. Pandey, Carla Biesdorf, Andi R. Masters, Kristen D. Onos, Leslie Haynes, Kelly J. Keezer, Jill A. Meyer, Jonathan S. Peters, Scott A. Persohn, Amanda A. Bedwell, Kierra Eldridge, Rachael Speedy, Gabriela Little, Sean‐Paul Williams, Brenda Noarbe, Andre Obenaus, Michael Sasner, Gareth R. Howell, Gregory W. Carter, Harriet Williams, Bruce T. Lamb, Paul R. Territo, Stacey J. Sukoff Rizzo

“…Following treatment (6 months of age), in vivo imaging was conducted with 18F‐florbetapir (AV‐45/Amyvid) (18F‐AV45) and 18‐FDG (fluorodeoxyglucose)–PET (positron emission tomography)/MRI (magnetic resonance imaging), brain and plasma amyloid beta (Aβ) were measured, and the clinical and behavioral characteristics of the mice were assessed and correlated with the pharmacokinetic data. …”
Get full text

Adapentpronitrile, a New Dipeptidyl Peptidase-IV Inhibitor, Ameliorates Diabetic Neuronal Injury Through Inhibiting Mitochondria-Related Oxidative Stress and Apoptosis by Lu Yang, Wenli Han, Ying Luo, Xiangnan Hu, Ying Xu, Huan Li, Congli Hu, Dan Huang, Jie Ma, Yang Yang, Qi Chen, Yuke Li, Jiahua Zhang, Hui Xia, Zhihao Chen, Hong Wang, Dongzhi Ran, Junqing Yang

“…In the present study, we first found that adapentpronitrile significantly ameliorated neuronal injury and decreased amyloid precursor protein (APP) and amyloid beta (Aβ) expression in the hippocampus and cortex in the high fat diet/STZ rat model of diabetes. …”
Get full text

Antiviral therapy: Valacyclovir Treatment of Alzheimer’s Disease (VALAD) Trial: protocol for a randomised, double-blind,placebo-controlled, treatment trial by Howard Andrews, D P Devanand, William C Kreisl, Qolamreza Razlighi, Anne Gershon, Yaakov Stern, Akiva Mintz, Thomas Wisniewski, Edward Acosta, Julianna Pollina, Mariasofia Katsikoumbas, Karen L Bell, Gregory H Pelton, Deborah Deliyannides, K M Prasad

“…HSV1 (oral herpes) and HSV2 (genital herpes) can trigger amyloid beta-protein (Aβ) aggregation and HSV1 DNA is common in amyloid plaques. …”
Get full text

Cognitive practice effects delay diagnosis of MCI: Implications for clinical trials by Mark Sanderson‐Cimino, Jeremy A. Elman, Xin M. Tu, Alden L. Gross, Matthew S. Panizzon, Daniel E. Gustavson, Mark W. Bondi, Emily C. Edmonds, Graham M.L. Eglit, Joel S. Eppig, Carol E. Franz, Amy J. Jak, Michael J. Lyons, Kelsey R. Thomas, McKenna E. Williams, William S. Kremen, Alzheimer's Disease Neuroimaging Initiative

“…Cerebrospinal fluid amyloid beta, phosphorylated tau, and total tau were used for criterion validation. …”
Get full text

Rapamycin Attenuated Zinc-Induced Tau Phosphorylation and Oxidative Stress in Rats: Involvement of Dual mTOR/p70S6K and Nrf2/HO-1 Pathways by Chencen Lai, Chencen Lai, Zhuyi Chen, Yuanting Ding, Qian Chen, Songbai Su, Heng Liu, Ruiqing Ni, Ruiqing Ni, Zhi Tang

“…Alzheimer’s disease is pathologically characterized by abnormal accumulation of amyloid-beta plaques, neurofibrillary tangles, oxidative stress, neuroinflammation, and neurodegeneration. …”
Get full text

The cerebrospinal fluid biomarker ratio Aβ42/40 identifies amyloid positron emission tomography positivity better than Aβ42 alone in a heterogeneous memory clinic cohort by Michaela Amft, Marion Ortner, Udo Eichenlaub, Oliver Goldhardt, Janine Diehl-Schmid, Dennis M. Hedderich, Igor Yakushev, Timo Grimmer

“…We evaluated the performance of the amyloid beta (Aβ)42/40 ratio for predicting amyloid positivity by PET, compared with Aβ42 alone, and phosphorylated tau 181 (pTau181)/Aβ42 and total tau (tTau)/Aβ42 ratios, using fully automated CSF immunoassays (Roche Diagnostics International Ltd, Rotkreuz, Switzerland) in a heterogeneous cohort of patients with a range of cognitive disorders reflecting the typical population of a memory clinic. …”
Get full text

Linking Molecular Pathways and Large-Scale Computational Modeling to Assess Candidate Disease Mechanisms and Pharmacodynamics in Alzheimer's Disease by Leon Stefanovski, Leon Stefanovski, Paul Triebkorn, Paul Triebkorn, Andreas Spiegler, Andreas Spiegler, Margarita-Arimatea Diaz-Cortes, Margarita-Arimatea Diaz-Cortes, Margarita-Arimatea Diaz-Cortes, Ana Solodkin, Viktor Jirsa, Anthony Randal McIntosh, Petra Ritter, Petra Ritter, Petra Ritter, for the Alzheimer's Disease Neuroimaging Initiative

“…As a novelty, we connect chemical compounds measured with positron emission tomography (PET) with neural function in TVB addressing the phenomenon of hyperexcitability in AD related to the protein amyloid beta (Abeta). We construct personalized virtual brains based on an averaged healthy connectome and individual PET derived distributions of Abeta in patients with mild cognitive impairment (MCI, N = 8) and Alzheimer's Disease (AD, N = 10) and in age-matched healthy controls (HC, N = 15) using data from ADNI-3 data base (http://adni.loni.usc.edu). …”
Get full text

Natural essential oils derived from herbal medicines: A promising therapy strategy for treating cognitive impairment by Ai Shi, Ai Shi, Yu Long, Yu Long, Yin Ma, Yin Ma, Shuang Yu, Shuang Yu, Dan Li, Dan Li, Jie Deng, Jie Deng, Jing Wen, Jing Wen, Xiaoqiu Li, Xiaoqiu Li, Yuanyuan Wu, Yuanyuan Wu, Xiaofang He, Xiaofang He, Yue Hu, Yue Hu, Nan Li, Nan Li, Yuan Hu, Yuan Hu

“…Essential oils (EOs) extracted from natural herbs have a wide range of pharmacological components, low toxicity, and wide sources, In this review, we list the history of using volatile oils against cognitive disorders in several countries, summarize EOs and monomeric components with cognitive improvement effects, and find that they mainly act by attenuating the neurotoxicity of amyloid beta, anti-oxidative stress, modulating the central cholinergic system, and improving microglia-mediated neuroinflammation. …”
Get full text

Upregulation of Ca2+-binding proteins contributes to VTA dopamine neuron survival in the early phases of Alzheimer’s disease in Tg2576 mice by Livia La Barbera, Annalisa Nobili, Emma Cauzzi, Ilaria Paoletti, Mauro Federici, Luana Saba, Cecilia Giacomet, Ramona Marino, Paraskevi Krashia, Marcello Melone, Flavio Keller, Nicola Biagio Mercuri, Maria Teresa Viscomi, Fiorenzo Conti, Marcello D’Amelio

“…We have previously described a progressive and selective degeneration of these neurons in the Tg2576 mouse model of AD, long before amyloid-beta plaque formation. The degenerative process in DA neurons is associated with an autophagy flux impairment, whose rescue can prevent neuronal loss. …”
Get full text

Association of CSF Alzheimer's disease biomarkers with postoperative delirium in older adults by Tamara G. Fong, Sarinnapha M. Vasunilashorn, Yun Gou, Towia A. Libermann, Simon Dillon, Eva Schmitt, Steven E. Arnold, Pia Kivisäkk, Becky Carlyle, Esther S. Oh, Kamen Vlassakov, Lisa Kunze, Tammy Hshieh, Richard N. Jones, Edward R. Marcantonio, Sharon K. Inouye, For the RISE Study Group

“…CSF AD biomarkers were measured by enzyme‐linked immunosorbent assay (ELISA) (ADX/Euroimmun); cut points for amyloid, tau, and neurodegeneration (ATN) biomarker status were A = amyloid beta (Aβ)42 <175 pg/mL or Aβ42/40 ratio <0.07; T = p‐tau >80 pg/mL; and N = t‐tau >700 pg/mL. …”
Get full text

Impaired Hippocampal Neurovascular Coupling in a Mouse Model of Alzheimer’s Disease by Lin Li, Lin Li, Xin-Kang Tong, Mohammadamin Hosseini Kahnouei, Mohammadamin Hosseini Kahnouei, Mohammadamin Hosseini Kahnouei, Diane Vallerand, Diane Vallerand, Edith Hamel, Hélène Girouard, Hélène Girouard, Hélène Girouard, Hélène Girouard

“…Hippocampal NVC was studied in 6-month-old amyloid-beta precursor protein (APP) transgenic mice and their corresponding wild-type littermates using in vivo laser Doppler flowmetry to measure CBF in area CA1 of the hippocampus in response to Schaffer collaterals stimulation. …”
Get full text

Pleiotropic Effects of Variants in Dementia Genes in Parkinson Disease by Laura Ibanez, Umber Dube, Albert A. Davis, Maria V. Fernandez, John Budde, Breanna Cooper, Monica Diez-Fairen, Monica Diez-Fairen, Sara Ortega-Cubero, Sara Ortega-Cubero, Pau Pastor, Pau Pastor, Joel S. Perlmutter, Joel S. Perlmutter, Carlos Cruchaga, Bruno A. Benitez

“…However, the contribution of the dementia-causing genes to PD risk, cognitive impairment and dementia in PD is not fully established.Objective: To assess the contribution of coding variants in Mendelian dementia-causing genes on the risk of developing PD and the effect on cognitive performance of PD patients.Methods: We analyzed the coding regions of the amyloid-beta precursor protein (APP), Presenilin 1 and 2 (PSEN1, PSEN2), and Granulin (GRN) genes from 1,374 PD cases and 973 controls using pooled-DNA targeted sequence, human exome-chip and whole-exome sequencing (WES) data by single variant and gene base (SKAT-O and burden tests) analyses. …”
Get full text

Mechanistic insights into the potential role of dietary polyphenols and their nanoformulation in the management of Alzheimer’s disease by Hind Muteb Albadrani, Payal Chauhan, Sumel Ashique, M. Arockia Babu, Danish Iqbal, Abdulmajeed G. Almutary, Mosleh Mohammad Abomughaid, Mehnaz Kamal, Ana Cláudia Paiva-Santos, Mohammed Alsaweed, Munerah Hamed, Punya Sachdeva, Saikat Dewanjee, Saurabh Kumar Jha, Shreesh Ojha, Petr Salma, Niraj Kumar Jha

“…The two major pathophysiological factors responsible for AD are amyloid plaques (comprising amyloid-beta aggregates) and neurofibrillary tangles (consisting of hyperphosphorylated tau protein). …”
Get full text

Antagonization of OX₁ Receptor Potentiates CB₂ Receptor Function in Microglia from APP_Sw/Ind Mice Model by Iu Raïch, Joan Biel Rebassa, Jaume Lillo, Arnau Cordomi, Rafael Rivas-Santisteban, Alejandro Lillo, Irene Reyes-Resina, Rafael Franco, Gemma Navarro

“…Microdialysis assays demonstrated a possible role of orexin in the regulation of amyloid beta peptide (Aß) levels in the hippocampal interstitial fluid in the APP transgenic model. …”
Get full text

Serum Bile Acids Improve Prediction of Alzheimer's Progression in a Sex‐Dependent Manner by Tianlu Chen, Lu Wang, Guoxiang Xie, Bruce S. Kristal, Xiaojiao Zheng, Tao Sun, Matthias Arnold, Gregory Louie, Mengci Li, Lirong Wu, Siamak Mahmoudiandehkordi, Matthew J. Sniatynski, Kamil Borkowski, Qihao Guo, Junliang Kuang, Jieyi Wang, Kwangsik Nho, Zhenxing Ren, Alexandra Kueider‐Paisley, Colette Blach, Rima Kaddurah‐Daouk, Wei Jia, Alzheimer's Disease Neuroimaging Initiative (ADNI) and the Alzheimer Disease Metabolomics Consortium (ADMC)

“…Additionally, the key findings are validated in a subset of participants (n = 578) with cerebrospinal fluid amyloid‐beta and tau levels. These findings underscore the role of BAs in AD progression, offering potential improvements in the accuracy of AD prediction.…”
Get full text

APOE-ε4 risk variant for Alzheimer's disease modifies the association between cognitive performance and cerebral morphology in healthy middle-aged individuals by Raffaele Cacciaglia, José Luis Molinuevo, Carles Falcón, Gonzalo Sánchez-Benavides, Nina Gramunt, Anna Brugulat-Serrat, Manel Esteller, Sebastián Morán, Karine Fauria, Juan Domingo Gispert

“…In cognitively unimpaired individuals, it has been related to altered brain morphology, function and earlier amyloid beta accumulation. However, its impact on cognitive performance is less evident. …”
Get full text

Lack of association between bridging integrator 1 (BIN1) rs744373 polymorphism and tau‐PET load in cognitively intact older adults by Jolien Schaeverbeke, Emma S Luckett, Silvy Gabel, Mariska Reinartz, Steffi De Meyer, Isabelle Cleynen, Kristel Sleegers, Christine Van Broeckhoven, Guy Bormans, Kim Serdons, Koen Van Laere, Patrick Dupont, Rik Vandenberghe, and the Alzheimer's Disease Neuroimaging Initiative**

“…However, the association of BIN1 with in vivo tau, amyloid beta (Aβ) burden, and cognitive impairment in the asymptomatic stage of Alzheimer's disease (AD) remains unknown. …”
Get full text