A Metalloproteinase Cocktail from the Venom of <i>Protobothrops flavoviridis</i> Cleaves Amyloid Beta Peptides at the α-Cleavage Site by Eugene Futai, Hajime Kawasaki, Shinichi Sato, Khadija Daoudi, Masafumi Hidaka, Taisuke Tomita, Tomohisa Ogawa

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Molecular Cloning and Expression of Osmotin in a Baculovirus-Insect System: Purified Osmotin Mitigates Amyloid-beta Deposition in Neuronal Cells by Noman Bin Abid, Gwangho Yoon, Myeong Ok Kim

“…In vitro analysis of purified Osmotin protein showed excellent cell viability, p-AMPK activation and a reduction in amyloid-beta deposition. Immunofluorescent analysis showed significant reduction in amyloid beta deposition in APP over expressing neuronal cells. …”
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Protective effects of astragaloside IV against amyloid beta1-42 neurotoxicity by inhibiting the mitochondrial permeability transition pore opening. by Qinru Sun, Ning Jia, Weixi Wang, Hui Jin, Jiehua Xu, Haitao Hu

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Activation of autophagy by Citri Reticulatae Semen extract ameliorates amyloid-beta-induced cell death and cognition deficits in Alzheimer’s disease by Yong Tang, Jing Wei, Xiao-Fang Wang, Tao Long, Xiaohong Xiang, Liqun Qu, Xingxia Wang, Chonglin Yu, Xingli Xiao, Xueyuan Hu, Jing Zeng, Qin Xu, Anguo Wu, Jianming Wu, Dalian Qin, Xiaogang Zhou, Betty Yuen-Kwan Law

Subjects: “…alzheimer’s disease; amyloid-beta; apoptosis; autophagy; caenorhabditis elegans; citri reticulatae semen…”
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Reducing the Levels of Akt Activation by PDK1 Knock-in Mutation Protects Neuronal Cultures against Synthetic Amyloid-Beta Peptides by Shaobin Yang, Sònia Pascual-Guiral, Rebeca Ponce, Lydia Giménez-Llort, María A. Baltrons, Ottavio Arancio, Jose R. Palacio, Victoria M. Clos, Victor J. Yuste, Jose R. Bayascas

“…Moreover, these two mechanisms cooperatively provide the mutant neurons with resistance against amyloid-beta oligomers, and might singularly also contribute to protect these mice against amyloid-beta pathology.…”
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Increased processing of SINE B2 ncRNAs unveils a novel type of transcriptome deregulation in amyloid beta neuropathology by Yubo Cheng, Luke Saville, Babita Gollen, Christopher Isaac, Abel Belay, Jogender Mehla, Kush Patel, Nehal Thakor, Majid H Mohajerani, Athanasios Zovoilis

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Neuroprotective mechanism of Kai Xin San: upregulation of hippocampal insulin-degrading enzyme protein expression and acceleration of amyloid-beta degradation by Na Wang, Yong-ming Jia, Bo Zhang, Di Xue, Maharjan Reeju, Yan Li, Shu-ming Huang, Xue-wei Liu

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Early Cellular, Molecular, Morphological and Behavioral Changes in the Humanized Amyloid-Beta-Knock-In Mouse Model of Late-Onset Alzheimer’s Disease by Sudhir Kshirsagar, Rainier Vladlen Alvir, Ashly Hindle, Subodh Kumar, Murali Vijayan, Jangampalli Adi Pradeepkiran, Arubala P. Reddy, Bhagavathi Ramasubramanian, P. Hemachandra Reddy

Subjects: “…amyloid beta…”
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Correction: Lesion of the subiculum reduces the spread of amyloid beta pathology to interconnected brain regions in a mouse model of Alzheimer’s disease by Sonia George, Annica Rönnbäck, Gunnar K. Gouras, Géraldine H. Petit, Fiona Grueninger, Bengt Winblad, Caroline Graff, Patrik Brundin

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Studying the Inflammatory Responses to Amyloid Beta Oligomers in Brain-Specific Pericyte and Endothelial Co-Culture From Human Stem Cells by Mark Marzano, Xingchi Chen, Teal A. Russell, Angelica Medina, Zizheng Wang, Timothy Hua, Changchun Zeng, Changchun Zeng, Xueju Wang, Qing-Xiang Sang, Hengli Tang, Yeoheung Yun, Yan Li

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Chronic oral application of a periodontal pathogen results in brain inflammation, neurodegeneration and amyloid beta production in wild type mice. by Vladimir Ilievski, Paulina K Zuchowska, Stefan J Green, Peter T Toth, Michael E Ragozzino, Khuong Le, Haider W Aljewari, Neil M O'Brien-Simpson, Eric C Reynolds, Keiko Watanabe

“…The hippocampi were examined for the signs of neuropathology related to AD: TNFα, IL1β, and IL6 expression (neuroinflammation), NeuN and Fluoro Jade C staining (neurodegeneration) and amyloid beta1-42 (Aβ42) production and phosphorylation of tau protein at Ser396 were assessed by IF and confocal microscopy. …”
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Computational design of new Peptide inhibitors for amyloid Beta (aβ) aggregation in Alzheimer's disease: application of a novel methodology. by Gözde Eskici, Mert Gur

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Observation of Intact and Proteolytically Cleaved Amyloid-Beta (1–40)-Oleuropein Noncovalent Complex at Neutral pH by Mass Spectrometry by Ioana Cezara Caba, Raluca Ştefănescu, Bogdan Ionel Tamba

“…Our results highlight the importance of further studies on the effect of oleuropein against amyloid beta aggregation.…”
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The Cannabinoids, CBDA and THCA, Rescue Memory Deficits and Reduce Amyloid-Beta and Tau Pathology in an Alzheimer’s Disease-like Mouse Model by Juyong Kim, Pilju Choi, Young-Tae Park, Taejung Kim, Jungyeob Ham, Jin-Chul Kim

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Amyloid-Beta Induces Different Expression Pattern of Tissue Transglutaminase and Its Isoforms on Olfactory Ensheathing Cells: Modulatory Effect of Indicaxanthin by Agata Campisi, Giuseppina Raciti, Giovanni Sposito, Rosaria Grasso, Maria A. Chiacchio, Michela Spatuzza, Alessandro Attanzio, Ugo Chiacchio, Luisa Tesoriere, Mario Allegra, Rosalia Pellitteri

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Fucosterol from an Edible Brown Alga Ecklonia stolonifera Prevents Soluble Amyloid Beta-Induced Cognitive Dysfunction in Aging Rats by Jeong Hwan Oh, Jae Sue Choi, Taek-Jeong Nam

“…However, little is known about its effects on soluble amyloid beta peptide (sA&beta;)-induced endoplasmic reticulum (ER) stress and cognitive impairment. …”
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Different curcumin forms selectively bind fibrillar amyloid beta in post mortem Alzheimer’s disease brains: Implications for in-vivo diagnostics by Jurre den Haan, Tjado H. J. Morrema, Annemieke J. Rozemuller, Femke H. Bouwman, Jeroen J. M. Hoozemans

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MRI tractographic validation of drug-enhanced hepatic clearance of amyloid-beta and the therapeutic potential for Alzheimer's Disease: A pilot study by Anindita Bhattacharjee, Prasun K. Roy

“…Alzheimer's disease (AD) may require alternative therapeutic perspectives as current interventions may sometimes be sub-optimal. Amyloid-beta 42 (Aβ42) is mainly eliminated by hepatic clearance which diminishes in AD, hence hepatomodulatory drugs enhancing this clearance may have potentiality for therapeutic implication. …”
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The relationship between blood lipids and plasma amyloid beta is depend on blood pressure: a population-based cross-sectional study by Ningwei Hu, Ling Gao, Yu Jiang, Shan Wei, Suhang Shang, Chen Chen, Liangjun Dang, Jin Wang, Kang Huo, Meiying Deng, Jingyi Wang, Qiumin Qu

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THE NEUROTOXIC AMYLOID BETA OLIGOMERS IMPAIR GABAZINE-INDUCED NUCLEAR CA2+ SIGNALS AND THE EXPRESSION OF NEUROPROTECTIVE GENES IN HIPPOCAMPAL NEURONS. by Pedro Lobos Zambrano, Ignacio Vega, Barbara Bruna, Silvia Gleitze, Jorge Toledo, Steffen Hartel, Maria Hidalgo, Andrea Paula-Lima

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