Deciphering the Disaggregation Mechanism of Amyloid Beta Aggregate by 4-(2-Hydroxyethyl)-1-Piperazinepropanesulfonic Acid Using Electrochemical Impedance Spectroscopy by Hien T. Ngoc Le, Sungbo Cho

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Human single chain Fv antibodies and a complementarity determining region-derived peptide binding to amyloid-beta 1–42 by K. Manoutcharian, G. Acero, M.E. Munguia, B. Becerril, L. Massieu, T. Govezensky, E. Ortiz, J.D. Marks, C. Cao, K. Ugen, G. Gevorkian

“…A library of phage-displayed human single-chain Fv (scFv) antibodies was selected against the human amyloid-beta peptide (Aβ42). Two new anti-Aβ42 phage-displayed scFvs antibodies were obtained, and the sequences of their VH and Vκ genes were analyzed. …”
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High-frequency (50 Hz) electroacupuncture ameliorates cognitive impairment in rats with amyloid beta 1–42-induced Alzheimer's disease by Chao-Chao Yu, Ying Wang, Feng Shen, Li-Hong Kong, Ya-Wen Wang, Hua Zhou, Lei Tang

“…Rat models of Alzheimer's disease were established by injecting amyloid beta 1–42 (Aβ1–42) into the bilateral lateral ventricles. …”
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Neuroinflammation and amyloid-beta 40 are associated with reduced serotonin transporter (SERT) activity in a transgenic model of familial Alzheimer’s disease by Athanasios Metaxas, Marco Anzalone, Ramanan Vaitheeswaran, Sussanne Petersen, Anne M. Landau, Bente Finsen

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Coordination chemistry of ligands: insights into the design of amyloid beta/tau-PET imaging probes and nanoparticles-based therapies for Alzheimer's disease by Selvan, Subramanian Tamil, Ravichandar, Roopa, Ghosh, Krishna Kanta, Mohan, A., Mahalakshmi, Pachaiyappan, Gulyás, Balázs, Padmanabhan, Parasuraman

“…Despite the use of amyloid beta (Aβ) positron emission tomography (PET) gold standard [11C]-PiB, other approved benzothiazole ([18F]-flutemetamol) and stilbene derivative ([18F]-florbetaben and [18F]-florbetapir) based probes have been extensively studied and advocated as potential early Aβ PET radioligands for AD. …”
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Amyloid fibril formation by a synthetic peptide from a region of human acetylcholinesterase that is homologous to the Alzheimer's amyloid-beta peptide. by Cottingham, MG, Hollinshead, MS, Vaux, D

“…A region near the C-terminus of human acetylcholinesterase (AChE) is weakly homologous with the N-terminus of the Alzheimer's disease amyloid-beta peptide. We report that a 14-amino acid synthetic polypeptide whose sequence corresponds to residues 586-599 of the human synaptic or T form of AChE assembles into amyloid fibrils under physiological conditions. …”

Optogenetic activation of SST-positive interneurons restores hippocampal theta oscillation impairment induced by soluble amyloid beta oligomers in vivo by Chung, H, Park, K, Jang, H, Kohl, M, Kwag, J

Amyloid beta(1-40)-induced astrogliosis and the effect of genistein treatment in rat: a three-dimensional confocal morphometric and proteomic study. by Maryam Bagheri, Arjang Rezakhani, Sofie Nyström, Maria V Turkina, Mehrdad Roghani, Per Hammarström, Simin Mohseni

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A Probeless Capacitive Biosensor for Direct Detection of Amyloid Beta 1-42 in Human Serum Based on an Interdigitated Chain-Shaped Electrode by Hien T. Ngoc Le, Jinsoo Park, Sungbo Cho

“…Amyloid beta (aβ) 1-42, a peptide that is 1-42 amino acids long, is a major component of senile plaques in the brains of patients with Alzheimer’s disease. …”
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Effects of Donepezil Treatment on Brain Metabolites, Gut Microbiota, and Gut Metabolites in an Amyloid Beta-Induced Cognitive Impairment Mouse Pilot Model by Jae-Kwon Jo, Gihyun Lee, Cong Duc Nguyen, Seong-Eun Park, Eun-Ju Kim, Hyun-Woo Kim, Seung-Ho Seo, Kwang-Moon Cho, Sun Jae Kwon, Jae-Hong Kim, Hong-Seok Son

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Transcending the amyloid-beta dominance paradigm in Alzheimer's disease: An exploration of behavioural, metabolic, and gut microbiota phenotypes in 5xFAD mice by Dina Medina-Vera, Emma N. Zambrana-Infantes, Antonio J. López-Gambero, Julia Verheul-Campos, Luis J. Santín, Elena Baixeras, Juan Suarez, Francisco J. Pavon, Cristina Rosell-Valle, Fernando Rodríguez de Fonseca

“…However, the role of amyloid-beta (Aβ) as the sole cause of these changes is being questioned. …”
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Mutation-based structural modification and dynamics study of amyloid beta peptide (1–42): An in-silico-based analysis to cognize the mechanism of aggregation by Pritam Kumar Panda, Abhaysinha Satish Patil, Priyam Patel, Hetalkumar Panchal, Dr.

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Impact of amyloid-beta changes on cognitive outcomes in Alzheimer’s disease: analysis of clinical trials using a quantitative systems pharmacology model by Hugo Geerts, Athan Spiros, Patrick Roberts

“…Methods We present an advanced mechanism-based and biophysically realistic quantitative systems pharmacology computer model of an Alzheimer-type neuronal cortical network that has been calibrated with Alzheimer Disease Assessment Scale, cognitive subscale (ADAS-Cog) readouts from historical clinical trials and simulated the differential impact of amyloid-beta (Aβ40 and Aβ42) oligomers on glutamate and nicotinic neurotransmission. …”
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A Positive Feedback Loop of Hippo- and c-Jun-Amino-Terminal Kinase Signaling Pathways Regulates Amyloid-Beta-Mediated Neurodegeneration by Madison Irwin, Meghana Tare, Aditi Singh, Oorvashi Roy Puli, Neha Gogia, Matthew Riccetti, Prajakta Deshpande, Madhuri Kango-Singh, Madhuri Kango-Singh, Madhuri Kango-Singh, Madhuri Kango-Singh, Amit Singh, Amit Singh, Amit Singh, Amit Singh, Amit Singh

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Regional correlations between [11C]PIB PET and post-mortem burden of amyloid-beta pathology in a diverse neuropathological cohort by Sang Won Seo, Nagehan Ayakta, Lea T. Grinberg, Sylvia Villeneuve, Manja Lehmann, Bruce Reed, Charles DeCarli, Bruce L. Miller, Howard J. Rosen, Adam L. Boxer, James P. O’Neil, Lee-Way Jin, William W. Seeley, William J. Jagust, Gil D. Rabinovici

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Cholesterol, Amyloid Beta, Fructose, and LPS Influence ROS and ATP Concentrations and the Phagocytic Capacity of HMC3 Human Microglia Cell Line by Oscar M. Muñoz Herrera, Brian V. Hong, Ulises Ruiz Mendiola, Izumi Maezawa, Lee-Way Jin, Carlito B. Lebrilla, Danielle J. Harvey, Angela M. Zivkovic

“…HMC3 microglia were treated with cholesterol (Chol), amyloid beta oligomers (AβO), lipopolysaccharide (LPS), and fructose individually and in combination. …”
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Amyloid-Beta_1-42 -Induced Increase in GABAergic Tonic Conductance in Mouse Hippocampal CA1 Pyramidal Cells by Beatriz Calvo-Flores Guzmán, SooHyun Kim, Bhavya Chawdhary, Katie Peppercorn, Warren P Tate, Henry J Waldvogel, Richard LM Faull, Johanna Montgomery, Andrea Kwakowsky

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Antibody-conjugated, dual-modal, near-infrared fluorescent iron oxide nanoparticles for antiamyloidgenic activity and specific detection of amyloid-β fibrils by Skaat H, Corem-Slakmon E, Grinberg I, Last D, Goez D, Mardor Y, Margel S

“…Keywords: near-infrared fluorescent γ-Fe2O3 nanoparticles, protein folding, amyloid-β peptide, passive immunotherapy, neurodegenerative diseases…”
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Off-target binding of an anti-amyloid beta monoclonal antibody to platelet factor 4 causes acute and chronic toxicity in cynomolgus monkeys by Lise I. Loberg, Meha Chhaya, Alexander Ibraghimov, Edit Tarcsa, Andreas Striebinger, Andreas Popp, Lili Huang, Frank Oellien, Stefan Barghorn

“…ABT-736 is a humanized monoclonal antibody generated to target a specific conformation of the amyloid-beta (Aβ) protein oligomer. Development of ABT-736 for Alzheimer’s disease was discontinued due to severe adverse effects (AEs) observed in cynomolgus monkey toxicity studies. …”
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Positive Effect of Cognitive Reserve on Episodic Memory, Executive and Attentional Functions Taking Into Account Amyloid-Beta, Tau, and Apolipoprotein E Status by Justinas Narbutas, Justinas Narbutas, Daphne Chylinski, Maxime Van Egroo, Mohamed Ali Bahri, Ekaterina Koshmanova, Gabriel Besson, Vincenzo Muto, Christina Schmidt, Christina Schmidt, André Luxen, Evelyne Balteau, Christophe Phillips, Pierre Maquet, Pierre Maquet, Eric Salmon, Eric Salmon, Eric Salmon, Gilles Vandewalle, Christine Bastin, Christine Bastin, Fabienne Collette, Fabienne Collette

“…The allostatic load consisted of measures of lipid metabolism and sympathetic nervous system functioning. The amyloid-beta level was assessed using positron emission tomography in all participants, whereas tau/neuroinflammation positron emission tomography scans and apolipoprotein E genotype were available for 58 participants. …”
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