Structure-Based Peptide Design to Modulate Amyloid Beta Aggregation and Reduce Cytotoxicity. by Jitendra Kumar, Risa Namsechi, Valerie L Sim

Get full text

Low levels of amyloid-beta and its transporters in neonatal rats with and without hydrocephalus by Silverberg Gerald D, Klinge Petra M, Hsu Edward W, Abdullah Osama, Forsyth Jennifer, Deren Kelley E, Johanson Conrad E, McAllister James P

“…<p>Abstract</p> <p>Background</p> <p>Previous studies in aging animals have shown that amyloid-beta protein (Aβ) accumulates and its transporters, low-density lipoprotein receptor-related protein-1 (LRP-1) and the receptor for advanced glycation end products (RAGE) are impaired during hydrocephalus. …”
Get full text

In vitro screening on amyloid beta modulation of aqueous extracts from plant seeds by Yoshinori Okada, Mizue Okada

“…We conducted a screening of 14 aqueous extracts from plant seeds (PSAE) for inhibitory activity on amyloid beta (Aβ). Materials and Methods: To examine the effects of PSAE on the Aβ (1–42) concentration, PSAE were analyzed by Aβ (1–42) enzyme-linked immunosorbent assay. …”
Get full text

Elevation in sphingomyelin synthase activity is associated with increases in amyloid-beta peptide generation. by Jen-Hsiang T Hsiao, Yuhong Fu, Andrew F Hill, Glenda M Halliday, Woojin Scott Kim

“…A pathological hallmark of Alzheimer's disease (AD) is the presence of amyloid-beta peptide (Aβ) plaques in the brain. Aβ is derived from a sequential proteolysis of the transmenbrane amyloid precursor protein (APP), a process which is dependent on the distribution of lipids present in the plasma membrane. …”
Get full text

Amyloid-beta aggregation implicates multiple pathways in Alzheimer’s disease: Understanding the mechanisms by Musa O. Iliyasu, Sunday A. Musa, Sunday B. Oladele, Abdullahi I. Iliya

Subjects: Get full text

The HSP40 chaperone Ydj1 drives amyloid beta 42 toxicity by Julia Ring, Jelena Tadic, Selena Ristic, Michael Poglitsch, Martina Bergmann, Nemanja Radic, Dirk Mossmann, YongTian Liang, Marta Maglione, Andrea Jerkovic, Roozbeh Hajiraissi, Marcel Hanke, Victoria Küttner, Heimo Wolinski, Andreas Zimmermann, Lana Domuz Trifunović, Leonie Mikolasch, Daiana N Moretti, Filomena Broeskamp, Julia Westermayer, Claudia Abraham, Simon Schauer, Christopher Dammbrueck, Sebastian J Hofer, Mahmoud Abdellatif, Guido Grundmeier, Guido Kroemer, Ralf J Braun, Niklas Hansen, Cornelia Sommer, Mirjana Ninkovic, Sandra Seba, Patrick Rockenfeller, Friederike‐Nora Vögtle, Jörn Dengjel, Chris Meisinger, Adrian Keller, Stephan J Sigrist, Tobias Eisenberg, Frank Madeo

Subjects: Get full text

Machine learning prediction of future amyloid beta positivity in amyloid-negative individuals by Elaheh Moradi, Mithilesh Prakash, Anette Hall, Alina Solomon, Bryan Strange, Jussi Tohka, for the Alzheimer’s Disease Neuroimaging Initiative

Subjects: Get full text

Structure-based discovery of fiber-binding compounds that reduce the cytotoxicity of amyloid beta by Lin Jiang, Cong Liu, David Leibly, Meytal Landau, Minglei Zhao, Michael P Hughes, David S Eisenberg

“…Here we show that knowledge of the atomic structure of one of the adhesive, steric-zipper segments of the amyloid-beta (Aβ) protein of Alzheimer’s disease, when coupled with computational methods, identifies eight diverse but mainly flat compounds and three compound derivatives that reduce Aβ cytotoxicity against mammalian cells by up to 90%. …”
Get full text

Amyloid Beta and Phosphorylated Tau-Induced Defective Autophagy and Mitophagy in Alzheimer’s Disease by P. Hemachandra Reddy, Darryll MA Oliver

Subjects: Get full text

Transmission of amyloid-beta and tau pathologies is associated with cognitive impairments in a primate by Suzanne Lam, Fanny Petit, Anne-Sophie Hérard, Susana Boluda, Sabiha Eddarkaoui, Martine Guillermier, The Brain Bank Neuro-C. E. B. Neuropathology Network, Luc Buée, Charles Duyckaerts, Stéphane Haïk, Jean-Luc Picq, Marc Dhenain

Get full text

Spermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer’s disease mouse model by Kiara Freitag, Nele Sterczyk, Sarah Wendlinger, Benedikt Obermayer, Julia Schulz, Vadim Farztdinov, Michael Mülleder, Markus Ralser, Judith Houtman, Lara Fleck, Caroline Braeuning, Roberto Sansevrino, Christian Hoffmann, Dragomir Milovanovic, Stephan J. Sigrist, Thomas Conrad, Dieter Beule, Frank L. Heppner, Marina Jendrach

“…Abstract Background Deposition of amyloid beta (Aβ) and hyperphosphorylated tau along with glial cell-mediated neuroinflammation are prominent pathogenic hallmarks of Alzheimer’s disease (AD). …”
Get full text

Small-Molecule Amyloid Beta-Aggregation Inhibitors in Alzheimer's Disease Drug Development by Sharmin Reza Chowdhury, Fangzhou Xie, Jinxin Gu, Lei Fu

Get full text

Cathepsin D: Analysis of its potential role as an amyloid beta degrading protease by Lisa Gallwitz, Lina Schmidt, André R.A. Marques, Andreas Tholey, Liam Cassidy, Irem Ulku, Gerhard Multhaup, Alessandro Di Spiezio, Paul Saftig

Subjects: Get full text

Wnt Signaling Rescues Amyloid Beta-Induced Gut Stem Cell Loss by Prameet Kaur, Ellora Hui Zhen Chua, Wen Kin Lim, Jiarui Liu, Nathan Harmston, Nicholas S. Tolwinski

Get full text

HIV-1 and Amyloid Beta Remodel Proteome of Brain Endothelial Extracellular Vesicles by Ibolya E. András, Brice B. Sewell, Michal Toborek

Subjects: Get full text

Amyloid-beta 40 as a biomarker of cognitive impairment in acute ischemic stroke by Aleksey A. Kulesh, Viktor E. Drobakha, Elena M. Kuklina, Vladimir V. Shestakov

“…Aim: to study the role of amyloid-beta 40 (Aβ 40) in the development of cognitive impairment in acute ischemic stroke.Materials and methods. …”
Get full text

Coumarin derivatives against amyloid-beta 40 – 42 peptide and tau protein by Kowalczyk Joanna, Skalicka-Wozniak Krystyna, Budzynska Barbara, Sayed Nesrine El, Espargaró Alba, Sabate Raimon

Get full text

Removal of extracellular human amyloid beta aggregates by extracellular proteases in C. elegans by Elisabeth Jongsma, Anita Goyala, José Maria Mateos, Collin Yvès Ewald

Subjects: Get full text

The relationship between amyloid-beta and brain capillary endothelial cells in Alzheimer’s disease by Yan-Li Zhang, Juan Wang, Zhi-Na Zhang, Qiang Su, Jun-Hong Guo

Subjects: “…alzheimer’s disease; amyloid beta; aβ clearance; blood-brain barrier; cerebral amyloid angiopathy; dementia; endothelial cells; oxidative stress; review; therapeutics; transcytosis…”
Get full text

Analyzing and Modeling the Kinetics of Amyloid Beta Pores Associated with Alzheimer's Disease Pathology. by Ghanim Ullah, Angelo Demuro, Ian Parker, John E Pearson

“…Amyloid beta (Aβ) oligomers associated with Alzheimer's disease (AD) form Ca2+-permeable plasma membrane pores, leading to a disruption of the otherwise well-controlled intracellular calcium (Ca2+) homeostasis. …”
Get full text