In Silico Drug Repurposing Framework Predicts Repaglinide, Agomelatine and Protokylol as TRPV1 Modulators with Analgesic Activity by Corina Andrei, Dragos Paul Mihai, Anca Zanfirescu, George Mihai Nitulescu, Simona Negres

“…The use of current analgesics is limited by low efficacy and important side effects. …”
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Discovery of a New Analgesic Peptide, Leptucin, from the Iranian Scorpion, <i>Hemiscorpius lepturus</i> by Sedigheh Bagheri-Ziari, Delavar Shahbazzadeh, Soroush Sardari, Jean-Marc Sabatier, Kamran Pooshang Bagheri

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Comparative study between the effect of dexmedetomidine and lidocaine infusion on intraoperative analgesic requirement and hemodynamics during craniotomy by Agnimitra Ghosal, Tanay Debnath, Soma Chakraborty, Debojyoti Das, Arpita Laha, Mohanchandra Mandal, Amita Acharjee

Subjects: “…analgesic; dexmedetomidine; fentanyl; hemodynamics; lidocaine; propofol…”
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Phytochemistry, anti-inflammatory and analgesic activities of the aqueous leaf extract of Lagenaria breviflora (Cucurbitaceae) in laboratory animals by Adeolu Adedapo, Temitayo Adewuyi, Margaret Sofidiya

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EVALUATION OF KNOWLEDGE AND BEHAVIOR ON ANALGESIC SELF-MEDICATION IN HEALTH AND NON-HEALTH STUDENTS AT MUHAMMADIYAH UNIVERSITY, YOGYAKARTA by Claryza Amelia Putri, Bangunawati Rahajeng

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Within subject, double blind, examination of opioid sensitivity in participant-reported, observed, physiologic, and analgesic outcomes by Caitlyn J. Durgin, Andrew S. Huhn, Cecilia L. Bergeria, Patrick H. Finan, Claudia M. Campbell, Denis G. Antoine, Kelly E. Dunn

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Differential interaction patterns of opioid analgesics with µ opioid receptors correlate with ligand-specific voltage sensitivity by Sina B Kirchhofer, Victor Jun Yu Lim, Sebastian Ernst, Noemi Karsai, Julia G Ruland, Meritxell Canals, Peter Kolb, Moritz Bünemann

“…There is a wide range of opioid analgesics, differing in their chemical structure and their properties of receptor activation and subsequent effects. …”
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Analgesic efficacy of low-dose intrathecal neostigmine in combination with fentanyl and bupivacaine for total knee replacement surgery by Amit Jain, Kajal Jain, Neerja Bhardawaj

“…Conclusions: The addition of 1 mcg neostigmine IT increased the duration of analgesia and decreased the analgesic consumption in 24 h in TKR. There was no increase in the incidence of adverse effects.…”
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Effects of various analgesics on pain perception and rate of tooth movement: a randomized controlled clinical study by Asem A Abdaljawwad, Dheaa H Al-Groosh

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Analgesic effect of subcutaneous injection of different concentrations of methylene blue after hemorrhoidectomy: A retrospective study by Qing Long, Jun Li, Yan Li

“…The VAS pain score and total analgesics consumption within 14 days in group A and group B were significantly lower than those in group C, but the differences between group A and group B were not statistically significant. …”
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Cardiopulmonary Effects and Pharmacokinetics of Dexmedetomidine Used as an Adjunctive Analgesic to Regional Anesthesia of the Oral Cavity with Levobupivacaine in Dogs by Matic Pavlica, Mojca Kržan, Ana Nemec, Tina Kosjek, Anže Baš, Alenka Seliškar

“…This study investigated the cardiopulmonary effects and pharmacokinetics of dexmedetomidine (DEX) used as an adjunctive analgesic for regional anesthesia of the oral cavity with levobupivacaine in anesthetized dogs. …”
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A systematic review on sex differences in adverse drug reactions related to psychotropic, cardiovascular, and analgesic medications by Yuting Shan, Lee Cheung, Yuqi Zhou, Yingbo Huang, R. Stephanie Huang

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Letter to the editor regarding “the analgesic effect and safety of duloxetine in total knee arthroplasty: A systematic review” by Xiaomeng Tian, Ying Xu, Ye Yang, Xiaoling Hou

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Comparative study of analgesic efficacy of levobupivacaine alone and levobupivacaine plus dexmedetomidine in patients undergoing laparoscopic cholecystectomy by Neha Pareek, Nikita Badmaliya, Sweta Bharadiya, Pramila Soni

“…Adding dexmedetomidine 1 μg/kg to intraperitoneal levobupivacaine 0.25% in LC decreases the postoperative analgesic needs in the postoperative period compared to levobupivacaine 0.25% alone and improves the quality and duration of analgesia.…”
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Evaluation of analgesic effect of cocktail therapy combined with adductor block on patients undergoing unicompartmental knee arthroplasty by ZHANG Hao-sha-qiang, JI Sha-sha, WANG Zhi-gang, TIAN Ye

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Analgesic Efficacy of Preemptive Transversus Abdominis Plane Block in Patients Undergoing Laparoscopic Colorectal Cancer Surgery by Kwan Young Hong, Duk Kyung Kim, Hue Jung Park, Woo Seog Sim, Won Gook Wi, Woo Yong Lee, Hee Cheol Kim, Jin Young Lee

“…Preemptive TAP block showed an intraoperative, but not postoperative, analgesic effect, characterized by a low mean arterial pressure, heart rate, and MAC.…”
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Study The Analgesic And Anti-Inflammatory Activity Of Zingiber Officinale Rhizome Extract Comparison With Ibuprofen In Male Mice by Amer Hakeem Chyad, Omar Salim Ibrahim, Ahmmed Hameed

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Analgesic Effects and Impairment in Locomotor Activity Induced by Cannabinoid/Opioid Combinations in Rat Models of Chronic Pain by Mohammad Alsalem, Ahmad Altarifi, Mansour Haddad, Belal Azab, Heba Kalbouneh, Amer Imraish, Tareq Saleh, Khalid El-Salem

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Metabolic Capability of <i>Penicillium oxalicum</i> to Transform High Concentrations of Anti-Inflammatory and Analgesic Drugs by Darío Rafael Olicón-Hernández, Maite Ortúzar, Clementina Pozo, Jesús González-López, Elisabet Aranda

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Comparison of the Effect of Intra-Articular, Periarticular, and Combined Injection of Analgesic on Pain Following Total Knee Arthroplasty by Seyed Mohammad Javad Mortazavi, MD, Farzad Vosoughi, MD, Mirsaeed Yekaninejad, MD, Ehsan Ghadimi, MD, Mohammad Hasan Kaseb, MD, Mohammad Ayati Firoozabadi, MD, Ehsan Fallah, MD, Hesam Toofan, MD, Seyed Khalil Pestehei, MD

“…The aim of this study was to compare the efficacy of 3 methods of intraoperative analgesic cocktail injection during total knee arthroplasty (TKA)—intra-articular (IA), periarticular (PA), and combined intra-articular and periarticular (IA+PA)—on controlling early postoperative pain. …”
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