Should we treat postvenereal Reiter's syndrome by antibiotics? by Wordsworth, B

Multicopy plasmids potentiate the evolution of antibiotic resistance in bacteria by San Millan, A, Escudero, J, Gifford, D, Mazel, D, MacLean, C

“…These results uncover a role for multicopy plasmids as catalysts for the evolution of antibiotic resistance in bacteria…”

Defining the appropriateness and inappropriateness of antibiotic prescribing in primary care by Smith, D, Dolk, F, Pouwels, K, Christie, M, Robotham, J, Smieszek, T

“…Objectives:To assess the appropriateness of prescribing systemic antibiotics for different clinical conditions in primary care, and to quantify 'ideal' antibiotic prescribing proportions in conditions for which antibiotic treatment is sometimes but not always indicated. …”

Antibiotic susceptibility of Neisseria gonorrhoeae in Vientiane, Lao PDR by Phouangsouvanh, S, Mayxay, M, Keoluangkhot, V, Vongsouvath, M, Davong, V, Dance, D

“… <h4>Objectives</h4> <p>To determine the antibiotic susceptibility of N. gonorrhoeae in the Lao People’s Democratic Republic (Laos).…”

Are antibiotics effective for adults and children with acute sore throats? by Mar, D, Glasziou, P, Spinks, AB

South Asia today: William Osler's world with antibiotics by Basnyat, B

“…Typhoid and typhus fevers are the first two chapters in William Osler’s The Principles and Practice of Medicine, published in 1892.1 It is disheartening that well over a century later, south Asia continues to have a large burden of these diseases, despite antibiotics. Additionally, antimicrobial resistance—including antibiotic-resistant typhoid fever—is on the increase. …”

Evolution of antibiotic resistance by human and bacterial niche construction. by Boni, M, Feldman, M

“…Antibiotic treatment by humans generates strong viability selection for antibiotic-resistant bacterial strains. …”

Differential antibiotic-induced endotoxin release in severe melioidosis. by Simpson, A, Opal, S, Angus, B, Prins, J, Palardy, J, Parejo, N, Chaowagul, W, White, N

“…No overall difference in mortality was observed (35% in both groups [95% confidence interval, 20%-50%]). Differential antibiotic-induced endotoxin release is demonstrable in severe melioidosis. …”

Exploitation of an iron transporter for bacterial protein antibiotic import. by White, P, Joshi, A, Rassam, P, Housden, N, Kaminska, R, Goult, J, Redfield, C, McCaughey, L, Walker, D, Mohammed, S, Kleanthous, K

“…Hence, energized nutrient transporters in bacteria also serve as rudimentary protein import systems, which, in the case of FpvAI, results in a protein antibiotic 60-fold bigger than the transporter's natural substrate being translocated across the OM.…”

Antibiotic prescribing and resistance in primary care: implications for intervention by Van Hecke, O

“…<p><b>Background</b></p> <p>Antibiotic resistance is an important societal health issue. …”

Antibiotics reduced the time to resolution of symptoms in otitis media by Burton, M, Glasziou, P

Topical antibiotics with steroids for chronic suppurative otitis media by Brennan-Jones, C, Chong, L, Head, K, Tu, N, Burton, M, Schilder, A, Bhutta, M

“…The objectives are as follows:</p> <p>To assess the effects of adding a topical steroid to topical antibiotics in the treatment of people with chronic suppurative otitis media (CSOM).…”

Does clinical error contribute to unnecessary antibiotic use? by McIsaac, W, Butler, C

“…Patient expectations and physician attitudes are often cited as factors in the overuse of antibiotics. This study examined whether clinical error might also be important. …”

Emergence of methicillin resistance predates the clinical use of antibiotics by Larsen, J, Raisen, CL, Ba, X, Rasmussen, S, Et al.

“…The discovery of antibiotics more than 80 years ago has led to considerable improvements in human and animal health. …”

Substandard and falsified antibiotics: neglected drivers of antimicrobial resistance? by Zabala, GA, Bellingham, K, Vidhamaly, V, Boupha, P, Boutsamay, K, Newton, PN, Caillet, C

“…<p><strong>Objectives</strong> Antimicrobial resistance (AMR) is a significant global health threat with substandard and falsified (SF) antibiotics being neglected contributing factors. With their relationships poorly understood, more research is needed in order to determine how interventions to reduce SF antibiotics should be ranked as priorities in national AMR action plans. …”

Testing the role of multicopy plasmids in the evolution of antibiotic resistance by Escudero, J, MacLean, R, San Millan, A

“…This "evolutionary rescue" approach provides a simple method to test the potential of multicopy plasmids to promote the acquisition of antibiotic resistance. In the next step of the experimental system, the molecular bases of antibiotic resistance are characterized. …”

Clinical considerations for antibiotic choices in the treatment of severe malaria. by Färnert, A, Gwer, S, Berkley, J

Oral versus intravenous antibiotics for bone and joint infection by Li, H-K, Rombach, I, Zambellas, R, Walker, S, Lipsky, BA, Kümin, M, Scarborough, C, Matthews, P, Brent, AJ, Angus, B, Cooper, C, Alvand, A, Thwaites, G, Bejon, P, Scarborough, M, al., E

“…<p><strong>Background</strong> The management of complex orthopedic infections usually includes a prolonged course of intravenous antibiotic agents. We investigated whether oral antibiotic therapy is noninferior to intravenous antibiotic therapy for this indication.…”

Identifying and exploiting genes that potentiate the evolution of antibiotic resistance by Gifford, D, Furio, V, Papkou, A, Vogwill, T, Oliver, A, MacLean, RC

“…There is an urgent need to develop novel approaches for predicting and preventing the evolution of antibiotic resistance. Here, we show that the ability to evolve de novo resistance to a clinically important β-lactam antibiotic, ceftazidime, varies drastically across the genus Pseudomonas. …”

Utilization of antibiotics in primary healthcare setting / Shafinaz Shamsuddin by Shamsuddin, Shafinaz

Subjects: “…Antibiotic therapy. Antibiotics…”
Get full text