Antibiotics induce redox-related physiological alterations as part of their lethality by Martell, Jeffrey Daniel, Takahashi, Noriko, Vercruysse, Maarten, Ting, Alice Y., Walker, Graham C., Dwyer, Daniel J., Belenky, Peter A., Yang, Jason H., MacDonald, I. Cody, Chan, Tsz Yan Clement, Lobritz, Michael A., Braff, Dana, Schwarz, Eric G., Ye, Jonathan D., Pati, Mekhala, Ralifo, Paul S., Allison, Kyle R., Khalil, Ahmad S., Collins, James J.

“…Deeper understanding of antibiotic-induced physiological responses is critical to identifying means for enhancing our current antibiotic arsenal. …”
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Inhibitors of energy metabolism interfere with antibiotic-induced death in mycobacteria by Lee, Bei Shi, Kalia, Nitin Pal, Jin, Xin Er F., Hasenoehrl, Erik J., Berney, Michael, Pethe, Kevin

“…Energy metabolism has recently gained interest as a target space for antibiotic drug development in mycobacteria. Of particular importance is bedaquiline (Sirturo), which kills mycobacteria by inhibiting the F1F0 ATP synthase. …”
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Sick pets as potential reservoirs of antibiotic-resistant bacteria in Singapore by Hartantyo, Sri Harminda Pahm, Chau, Man Ling, Fillon, Laurent, Ahmad Zhafir Mohamad Ariff, Kang, Joanne Su Lin, Aung, Kyaw Thu, Gutiérrez, Ramona Alikiiteaga

“…Resistance to broad-spectrum antibiotics were also observed among individual species. …”
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Ribosome protection by antibiotic resistance ATP-binding cassette protein by Su, Weixin, Kumar, Veerendra, Ding, Yichen, Ero, Rya, Serra, Aida, Lee, Benjamin Sian Teck, Wong, Andrew See Weng, Shi, Jian, Sze, Siu Kwan, Yang, Liang, Gao, Yong-Gui

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Investigating the degradation kinetics of sulfamethazine for antibiotic wastewater treatment processes by Chia, Sarah Tian Le

“…Antibiotics are consumed in healthcare or agriculture in large quantities. …”
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Sustaining antimicrobial stewardship in a high-antibiotic resistance setting by Ng, Tat Ming, Heng, Shi Thong, Chua, Boon Hou, Ang, Li Wei, Tan, Sock Hoon, Tay, Hui Lin, Yap, Min Yi, Quek, Jason, Teng, Christine B., Young, Barnaby Edward, Lin, Ray, Ang, Brenda, Lee, Tau Hong, Lye, David C.

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Antibiotic therapy in the treatment of COVID-19 pneumonia: who and when? by Ng, Tat Ming, Ong, Sean W. X., Loo, Audrey Y. X., Tan, Sock Hoon, Tay, Hui Lin, Yap, Min Yi, Lye, David C., Lee, Tau Hong, Young, Barnaby Edward

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Inhibitors of the oxidative phosphorylation pathway and their interaction with antibiotics in Mycobacteroides abscessus by Lim, Ting

“…In exploring the underlying mechanisms, we discovered that some classical antibiotics, in particular the β-lactams, rely on upregulation of bacterial metabolism to cause cell death. …”
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Rational design and synthesis of degradable poly(imidazolium ester) antibiotics by Xu, Xiaofei

“…The essential quest for innovative medications to address drug-resistant bacterial infections carries immense importance, owing to the widespread emergence of bacterial resistance against traditional antibiotics. While antimicrobial polymers have been explored as promising substitutes for antibiotics in academic scenarios, a majority of these polymers feature non-degradable backbones. …”
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Antibiotic delivery across the blood-brain barrier by nanoparticle system by Liu, Li Hong

“…Brain infection, especially bacterial and fungal meningitis, remains to be life-threatening disease despite the existence of numerous clinically available antibiotics. Important challenges include the antimicrobial agent transportation restricted by the blood-brain barrier (BBB) and multi-drug resistance presented by pathogenic microorganisms. …”
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Photocatalysis of antibiotic sulfamethazine by titanium dioxide supported on activated carbon by Wong, Tze Ying.

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Steroid-Decorated Antibiotic Microparticles for Inhaled Anti-Infective Therapy by Lee, Sie Huey, Teo, Jeanette, Heng, Desmond, Zhao, Yanli, Ng, Wai Kiong, Chan, Hak-Kim, Tan, Reginald B. H.

“…Unfortunately, no combined steroid–antibiotic dry powder formulation is available commercially or has been reported in the academic literature. …”
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Co-delivery of nitric oxide and antibiotic using polymeric nanoparticles by Nguyen, Thuy-Khanh, Selvanayagam, Ramona, Ho, Kitty K. K., Chen, Renxun, Kutty, Samuel K., Rice, Scott A., Kumar, Naresh, Barraud, Nicolas, Duong, Hien T. T., Boyer, Cyrille

“…In addition, a decrease in the effectiveness of antibiotics caused by the emergence of drug resistance in pathogens living in biofilm communities poses a significant threat to our health system. …”
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Potential for reducing inappropriate antibiotic prescribing in English primary care by Smieszek, T, Pouwels, K, Dolk, F, Smith, D, Hopkins, S, Sharland, M, Hay, A, Moore, M, Robotham, J

“…Objectives: To identify and quantify inappropriate systemic antibiotic prescribing in primary care in England, and ultimately to determine the potential for reduction in prescribing of antibiotics. …”

Pyrrhic progress - antibiotics and western food production (1949-2013) by Kirchhelle, C

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Cochrane corner: antibiotic prophylaxis for mammalian bites (intervention review). by Henton, J, Jain, A

“…OBJECTIVES: To determine if the use of prophylactic antibiotics in mammalian bites is effective in preventing bite-wound infection. …”

The evolution of strategy in bacterial warfare via the regulation of bacteriocins and antibiotics by Niehus, R, Oliveira, NM, Li, A, Fletcher, AG, Foster, KR

“…Bacteria inhibit and kill one another with a diverse array of compounds, including bacteriocins and antibiotics. These attacks are highly regulated, but we lack a clear understanding of the evolutionary logic underlying this regulation. …”

Overuse of antibiotics: can viral vaccinations help stem the tide? by Miller, L, Costelloe, CE, Robotham, JV, Pouwels, K

Meta-analysis of antibiotics for simple hand injuries requiring surgery by Murphy, GRF, Gardiner, MD, Glass, GE, Kreis, IA, Jain, A, Hettiaratchy, S

“…There was no significant difference in infection rate between the antibiotic and placebo/no antibiotic groups (RR 0·89, 95 per cent c.i. 0·65 to 1·23; P = 0·49). …”

Young infant sepsis: aetiology, antibiotic susceptibility and clinical signs. by Newton, O, English, M

“…Improved country level data on pattern of microorganisms, resistance and antibiotic use are required to help reduce mortality through development of local, evidence-based clinical guidelines.…”