Development of small-molecule reporters for fluorescence imaging of enzymes function and application by Cheong, Haolun

“…Of interests, β-lactamases activity is a serious medical concern as it promotes the bacteria resistance against the conventional antibiotic drugs. Therefore, in order to better understand the enzyme functions and combat against drug resistance, we demonstrated the use of metabolic-mediated fluorescent reporter to specifically detect and visualize class C β-lactamases enzyme in resistant bacteria for in vivo application in chapter 5. …”
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An in-vitro evaluation of C-di-GMP mediated biofilm dispersal as a potential strategy to restore antimicrobial efficacy by Roizman, Dan

“…AMR can evolve due to mutations that reduce antibiotic susceptibility or due to activation of various innate mechanisms of tolerance, for example, biofilm formation. …”
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Induksi Kerusakan pada Sel Epitel (HeLa) oleh Bakteri Komensal Oral Streptococcus sanguinis by Susilowati, Heni, Hutomo, Maria Margareta Suryani, Lenggogen, Puti

“…Streptococcus sanguinis bacterial suspension (107 cells/ml) was added to the culture and incubated for 24 and 48 hours in antibiotic-free culture medium. HeLa cells morphological analysis was performed under phase contrast and fluorescence microscope observation after Hoechst 33342 staining. …”
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Changes in the incidence of invasive disease due to Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis during the COVID-19 pandemic in 26 countries and te... by Brueggemann, AB, Jansen van Rensburg, MJ, Shaw, D, McCarthy, ND, Jolley, KA, Maiden, MCJ, van der Linden, MPG, Amin-Chowdhury, Z, Bennett, DE, Borrow, R, Brandileone, M-CC, Broughton, K, Campbell, R, Cao, B, Casanova, C, Choi, EH, Chu, YW, Clark, SA, Claus, H, Coelho, J, Corcoran, M, Cottrell, S, Cunney, RJ, Dalby, T, Davies, H, de Gouveia, L, Deghmane, A-E, Demczuk, W, Desmet, S, Drew, RJ, du Plessis, M, Erlendsdottir, H, Fry, NK, Fuursted, K, Gray, SJ, Henriques-Normark, B, Hale, T, Hilty, M, Hoffmann, S, Humphreys, H, Ip, M, Jacobsson, S, Johnston, J, Kozakova, J, Kristinsson, KG, Krizova, P, Kuch, A, Ladhani, SN, Lâm, T-T, Lebedova, V

“…<br><strong>Funding<br></strong> Wellcome Trust (UK), Robert Koch Institute (Germany), Federal Ministry of Health (Germany), Pfizer, Merck, Health Protection Surveillance Centre (Ireland), SpID-Net project (Ireland), European Centre for Disease Prevention and Control (European Union), Horizon 2020 (European Commission), Ministry of Health (Poland), National Programme of Antibiotic Protection (Poland), Ministry of Science and Higher Education (Poland), Agencia de Salut Pública de Catalunya (Spain), Sant Joan de Deu Foundation (Spain), Knut and Alice Wallenberg Foundation (Sweden), Swedish Research Council (Sweden), Region Stockholm (Sweden), Federal Office of Public Health of Switzerland (Switzerland), and French Public Health Agency (France).…”

Negative-pressure wound therapy versus standard dressings for adults with an open lower limb fracture: the WOLLF RCT by Costa, M, Achten, J, Bruce, J, Davis, S, Hennings, S, Willett, K, Petrou, S, Jeffery, S, Griffin, D, Parker, B, Masters, J, Lamb, S, Tutton, E, Parsons, N

“…Two specific areas of potentially great benefit are (1) the use of topical antibiotic preparations in the open-fracture wound and (2) the role of orthopaedic implants with antimicrobial coatings when fixing the associated fracture.…”

Genetic Transformation of Rice Cultivars Using Particle Bombardment for Salinity Tolerance by Htwe, Nwe Nwe

“…For genetic transformation, antibiotic resistance genes are routinely used as powerful markers for selection of transformed cells. …”
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Pathogenecity of Salmonella enteritidis phage type 1 isolate of Malaysia in 21 day old specific pathogen free chicken by Ahmad, S., Bejo, Mohd Hair, Zakaria, Zunita, Bejo, Siti Khairani

“…The chickens were raised separately in caging system and given free access to antibiotic-free ration and water. The SE and Mortality groups were inoculated orally (1.0 mL) with SE PT 1 (1x108 cfu mL-1). …”
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Effects of feeding different postbiotics produced by Lactobacillus plantarum on growth performance, carcass yield, intestinal morphology, gut microbiota composition, immune status,... by Merzza, Humam Ali, Loh, Teck Chwen, Foo, Hooi Ling, Samsudin, Anjas Asmara @ Ab Hadi, Mohamed Mustapha, Noordin, Idrus, Zulkifli, Wan Ibrahim, Wan Ahmad Izuddin

“…In conclusion, among the postbiotics applied in the current study as compared with NC, PC and AA, RI11 could be used as a potential alternative antibiotic growth promoter and anti-stress treatment in the poultry industry.…”
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Development of improved protocols for plant regeneration and genetic tranformation of rubber (Hevea brasiliensis Muell. Arg.) by Rahman, Md. Mahbubur

“…Transformed callus lines were selected and the stable expression of gfp gene detected without antibiotic pressure in rubber callus. In conclusion, the plant regeneration protocol via somatic embryogenesis developed using zygotic embryo explants of H. brasiliensis (Clone RRIM 901) has not been reported previously that could be applied to several rubber genotypes for production of large scale planting materials. …”
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Molecular characterization of bacteriocin loci in Lactobacillus plantarum I-UL4 by Tai, Hui Fong

“…Bacteriocin and bacteriocinogenic Lactic Acid Bacteria (LAB) have received special attention due to their potential applications as biopreservative, therapeutic agent and antibiotic-replacer in livestock animals. Lactobacillus plantarum, a member of LAB is found in various ecological niches with more than 10 types of bacteriocins have been reported for this species. …”
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Development Of An Avirulent Pasteurella Multocida B:2 By Disruption Of The Aba392 Dna Fragment by Mohamed Zulperi, Dzarifah

“…Verification of the 7kb ligation product with digestion by PstI, HindIII and XhoI restriction enzymes revealed the exact sizes of kanamycin cassette (1.2kb), pAKA19 (5.0kb) and the disrupted 804bp of ABA392 virulence gene (804bp). An antibiotic sensitivity test on P. multocida B:2 and the respective E. coli strains were performed in order to select the donor and recipient strains for conjugation process. …”
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Bacterial Endophytes From Oil Palm (Elaeis Guineensis) and Their Antagonistic Activity Against Ganoderma Boninense by Sapak, Zaiton

“…Endophytic bacteria have been found able to induce systemic resistance in plants and shown biological traits like antibiotic activity analysis. The use of endophytic microorganisms should be preferable to other biological control agents as they are internal colonizers, and therefore more able to compete in the vascular systems, depriving Ganoderma from both nutrients and space for its proliferation. …”
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Growth Response of Sweet Potato (Ipomoea Batatas L.) to Application of Selected Indigenous Plant Growth- Promoting Rhizobacteria and Nitrogen Fertilization by Farazana Yasmin

“…Four isolates were able to inhibit the fungal pathogens Rhizoctonia sp. and Pythium sp. The intrinsic antibiotic test showed that all isolates were resistant against Chloramphenicol (10 and 30 μg mL-1), Streptomycin (10 μg mL-1), Kanamycin (5 and 30 μg mL-1), Penicillin (10 μg mL-1) and Tetracyclin (30 μg mL-1). …”
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Potential use of selected antagonistic bacteria to control foot rot disease of black pepper (Piper nigrum L.) in Sarawak, Malaysia by Md Daut, Siti Noor Farhana

“…The potential of biocontrol agents were found to be able to induce systemic resistance in plants as well as showing biological control traits like producing antibiotic compounds which caused lysis to the phytopathogen cells. …”
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Evaluation of growth performance of juvenile African catfish [Clarias gariepinus (Burchell, 1822)] fed with striped catfish [Pangasius hypophthalmus (Sauvage, 1878)] viscera and pu... by Abu Bakar, Siti Nadia

“…The isolates also were found resistant to Vancomycin (30 μg) and Amoxilin (10 μg) while susceptible to Streptomycin (10 μg), Vancomycin (5 μg) and Ampicilin (10 μg) antibiotic disk. The suitability of dried fish viscera as feed ingredient in African catfish (initial size 2.71 ± 0.14 gm) were tested through feeding diet according to three different inclusion levels (10%, 20% and 30%) and it was found out that feed contained 20% of dried viscera yielded highest growth rate thus chosen for next feeding trial experiment. …”
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Effects of curry (Murraya koenigii spreng.) leaf extract on the microbial and physico-chemical qualities of yellow alkaline noodles during storage by Rosyid, Teza Alfindo

“…Tetracycline which was used as positive control (standard antibiotic) showed the highest IZD against GP and GN bacteria tested at i.e. in the range of 17.0 to 25.67 mm. …”
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Development and application of mass spectrometry-based metabolomics methods for disease biomarker identification by Tong, Lily Victoria

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Particle tracking for understanding the properties and dynamics of bacterial biofilms by Birjiniuk, Alona

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Safety and efficacy of whole-body chlorhexidine gluconate cleansing with or without emollient in hospitalised neonates (NeoCHG): a multicentre, randomised, open-label, factorial pi... by Russell, N, Clements, MN, Azmery, KS, Bekker, A, Bielicki, J, Dramowski, A, Ellis, S, Fataar, A, Hoque, M, LeBeau, K, O'Brien, S, Schiavone, F, Skoutari, P, Islam, MS, Saha, S, Walker, AS, Whitelaw, A, Sharland, M

“…<p><strong>Funding</p></strong> The MRC Joint Applied Global Health award, the Global Antibiotic Research and Development Partnership (GARDP), MRC Clinical Trials Unit core funding (UKRI) and St. …”

Estimates of the global, regional, and national morbidity, mortality, and aetiologies of lower respiratory infections in 195 countries, 1990-2016: a systematic analysis for the Glo... by Troeger, C, Blacker, BF, Khalil, IA, Rao, PC, Cao, S, Zimsen, SRM, Albertson, S, Stanaway, JD, Deshpande, A, Farag, T, Forouzanfar, MH, Abebe, Z, Adetifa, IMO, Adhikari, TB, Akibu, M, Lami, FH, Al-Eyadhy, A, Alvis-Guzman, N, Amare, AT, Amoako, YA, Antonio, CAT, Aremu, O, Asfaw, ET, Asgedom, SW, Atey, TM, Attia, EF, Avokpaho, EFGA, Ayele, HT, Ayuk, TB, Balakrishnan, K, Barac, A, Bassat, Q, Behzadifar, M, Behzadifar, M, Bhaumik, S, Bhutta, ZA, Bijani, A, Brauer, M, Brown, A, Camargos, PAM, Castaneda-Orjuela, CA, Colombara, D, Conti, S, Dadi, AF, Dandona, L, Dandona, R, Do, HP, Dubljanin, E, Edessa, D, Elkout, H, Endries, AY, Fijabi, DO, Foreman, KJ, Fullman, N, Garcia-Basteiro, AL, Gessner, BD, Gething, PW, Gupta, R, Gupta, T, Hailu, GB, Hassen, HY, Hedayati, MT, Heidari, M, Hibstu, DT, Horita, N, Ilesanmi, OS, Jakovljevic, MB, Jamal, AA, Kahsay, A, Kasaeian, A, Kassa, DH, Khader, YS, Khan, EA, Khan, MN, Khang, Y-H, Kim, YJ, Kissoon, N, Knibbs, LD, Kochhar, S, Koul, PA, Kumar, GA, Lodha, R, Razek, HM, Malta, DC, Mathew, JL, Mengistu, DT, Mezgebe, HB, Mohammad, KA, Mohammed, AM, Momeniha, F, Murthy, S, Nguyen, CT, Nielsen, KR, Ningrum, DNA, Nirayo, YL, Oren, E, Ortiz, JR, Mahesh, PA, Postma, MJ, Qorbani, M, Quansah, R, Rai, RK, Rana, SM, Ranabhat, CL, Ray, SE, Rezai, MS, Ruhago, GM, Safiri, S, Salomon, JA, Sartorius, B, Savic, M, Sawhney, M, She, J, Sheikh, A, Shiferaw, MS, Shigematsu, M, Singh, JA, Somayaji, R, Sufiyan, MB, Taffere, GR, Temsah, M-H, Thompson, MJ, Tobe-Gai, R, Topor-Madry, R, Tran, BX, Tran, TT, Tuem, KB, Ukwaja, KN, Vollset, SE, Walson, JL, Weldegebreal, F, Werdecker, A, West, TE, Yonemoto, N, Zaki, MES, Zhou, L, Zodpey, S, Vos, T, Lim, SS, Naghavi, M, Murray, CJL, Mokdad, AH, Hay, SI, Jr, RRC, Infecti, GBDLR

“…Interventions to improve wasting, household air pollution, ambient particulate matter pollution, and expanded antibiotic use could avert one under-5 death due to lower respiratory infection for every 4000 children treated in the countries with the highest lower respiratory infection burden.…”